Analysis of relationship between aldosterone level changes and renal function during perioperative period of renal transplantation

Fan Lianhui; Liu Long; He Long; Bi Xiaojun; Li Jian

doi:10.3969/j.issn.1674-7445.2016.02.010

Volume 7 Issue 2

Mar. 2016

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Fan Lianhui, Liu Long, He Long, et al. Analysis of relationship between aldosterone level changes and renal function during perioperative period of renal transplantation[J]. ORGAN TRANSPLANTATION, 2016, 7(2): 128-131. doi: 10.3969/j.issn.1674-7445.2016.02.010

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Analysis of relationship between aldosterone level changes and renal function during perioperative period of renal transplantation

doi: 10.3969/j.issn.1674-7445.2016.02.010

Department of Urology, the General Hospital of Shenyang Military Region, Shenyang 110016, China

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Corresponding author: Fan Lianhui, Email:flhurology@sina.com
Received Date: 2015-12-08
Available Online: 2021-01-19
Publish Date: 2016-03-15

Abstract

Abstract

Objective To investigate the relationship between changes of aldosterone level and renal function during perioperative period of renal transplantation and preliminarily discuss the role of aldosterone in chronic allograft nephropathy. Methods One hundred patients undergoing allogeneic renal transplantation in the Department of Urology of the General Hospital of Shenyang Military from January 1, 2010 to December 31, 2013 were assigned into the experimental group. According to the Scr levels measured at 30 d after renal transplantation, 100 patients were divided into groups A (Scr≥133 μmol/L, n=13) and B (Scr < 133 μmol/L, n=87). Ten healthy individuals aged 25-35 years were recruited into the control group. In the experimental group, blood sample was collected in the morning upon the day of renal transplantation (0 d), 1, 7, 15 and 30 d after renal transplantation. In the control group, blood sample was obtained at the same time points for measurement of aldosterone and Scr levels. Results On the day of renal transplantation, the Scr level in the experimental group was (598±37) μmol/L, significantly higher compared with (75±5) μmol/L in the control group (P < 0.05). The aldosterone level in the experimental group was (0.26±0.06) ng/dl, considerably higher than (0.13±0.03) ng/dl in the control group (P < 0.05). Compared with 0 d, the Scr levels of group A significantly decreased at postoperative 30 d (P < 0.05), whereas no statistical significance was noted in aldosterone levels between two time points (P > 0.05). In group B, both Scr and aldosterone levels were significantly decreased at postoperative 30 d (both in P < 0.05). Correlation analysis revealed that the serum level of aldosterone was positively correlated with Scr level changes (r=0.85, P < 0.05). Conclusions After renal transplantation, change of Scr level is positively correlated with aldosterone level alterations, probably suggesting that aldosterone plays a partial role in mediating injury of transplant kidney during renal transplantation.
- Renal transplantation,
- Aldosterone,
- Serum creatinine,
- Allograft nephropathy

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[1]	Rezaee-Zavareh MS, Ajudani R, Ramezani Binabaj M, et al. Kidney allograft stone after kidney transplantation and its association with graft survival[J]. Int J Organ Transplant Med, 2015, 6(3):114-118. http://www.ncbi.nlm.nih.gov/pubmed/26306157
[2]	Asher J, Vasdev N, Wyrley-Birch H, et al. A prospective randomised paired trial of sirolimus versus tacrolimus as primary immunosuppression following non-heart beating donor kidney transplantation[J]. Curr Urol, 2014, 7(4):174-180. https://www.ncbi.nlm.nih.gov/pubmed/26195946
[3]	苏子庭, 李珍, 曾仲, 等.活体肾移植供肾肾小球滤过率对术后移植肾功能恢复的影响[J].器官移植, 2015, 6(5):331-334, 339. http://www.organtranspl.com/browse/detail/qkid/32/id/129.html Su ZT, Li Z, Zeng Z, et al. Influence of glomerular filtration rate of living donor on recovery of graft function after transplantation[J]. Organ Transplant, 2015, 6(5):331-334, 339. http://www.organtranspl.com/browse/detail/qkid/32/id/129.html
[4]	Te Riet L, van Esch JH, Roks AJ, et al. Hypertension:renin-angiotensin-aldosterone system alterations[J].Circ Res, 2015, 116(6):960-975. doi: 10.1161/CIRCRESAHA.116.303587
[5]	Singh P, Feld RI, Colombe BW, et al. Sensitization, pathologic, and imaging findings comparing symptomatic and quiescent failed renal allografts[J]. Clin Transplant, 2014, 28(12):1424-1432. doi: 10.1111/ctr.2014.28.issue-12
[6]	Daniel C, Vogelbacher R, Stief A, et al. Long-term gene therapy with thrombospondin 2 inhibits TGF-β activation, inflammation and angiogenesis inchronic allograft nephropathy[J]. PLoS One, 2013, 8(12):e83846. doi: 10.1371/journal.pone.0083846
[7]	Sandhu JS, Kansal S, Bajwa GS, et al. Ocular changes in renal allograft recipients and patients of chronic kidney disease[J]. Saudi J Kidney Dis Transpl, 2014, 25(6):1285-1289. doi: 10.4103/1319-2442.144269
[8]	Vaidya A, Underwood PC, Hopkins PN, et al. Abnormal aldosterone physiology and cardiometabolic risk factors[J]. Hypertension, 2013, 61(4):886-893. doi: 10.1161/HYPERTENSIONAHA.111.00662
[9]	Bollag WB. Regulation of aldosterone synthesis and secretion[J]. Compr Physiol, 2014, 4(3):1017-1055.
[10]	Hart A, Jackson S, Kasiske BL, et al. Uric acid and allograft loss from interstitial fibrosis/tubular atrophy:post hoc analysis from the angiotensin Ⅱ blockade in chronic allograft nephropathy trial[J]. Transplantation, 2014, 97(10):1066-1071. doi: 10.1097/01.TP.0000440952.29757.66
[11]	Bernardi S, Toffoli B, Zennaro C, et al. Aldosterone effects on glomerular structure and function[J]. J Renin Angiotensin Aldosterone Syst, 2015, 16(4):730-738. doi: 10.1177/1470320315595568
[12]	范愈燕, 孙永新, 支楠, 等.醛固酮诱导大鼠肾脏衰老机制研究[J].中国临床药理学杂志, 2013, 29(1):42-44. http://www.cnki.com.cn/Article/CJFDTOTAL-GLYZ201301014.htm Fan YY, Sun YX, Zhi N, et al. Mechanism of aldosterone induced rat kidney senescence[J]. Chin J Clin Pharmacol, 2013, 29(1):42-44. http://www.cnki.com.cn/Article/CJFDTOTAL-GLYZ201301014.htm
[13]	Hsu TW, Liu JS, Hung SC, et al. Renoprotective effect of renin-angiotensin-aldosterone system blockade in patients with predialysis advanced chronic kidney disease, hypertension, and anemia[J]. JAMA Intern Med, 2014, 174(3):347-354. doi: 10.1001/jamainternmed.2013.12700
[14]	Mavrakanas TA, Gariani K, Martin PY. Mineralocorticoid receptor blockade in addition to angiotensin converting enzyme inhibitoror angiotensin Ⅱ receptor blocker treatment:an emerging paradigm in diabetic nephropathy:a systematic review[J]. Eur J Intern Med, 2014, 25(2):173-176. doi: 10.1016/j.ejim.2013.11.007
[15]	BarıŞ N, Özpelit E, Doğan NB, et al. The effects of chronic usage of angiotensin-converting enzyme inhibitors and angiotensin receptor blockers on contrast-induced nephropathy in low-risk patients[corrected][J]. Anadolu Kardiyol Derg, 2013, 13(3):245-250. https://www.ncbi.nlm.nih.gov/pubmed/23261803
[16]	Peng F, Su J, Lin J, et al. Impact of renin-angiotensin-aldosterone system-blocking agents on the risk of contrast-induced acute kidney injury:a prospective study and meta-analysis[J]. J Cardiovasc Pharmacol, 2015, 65(3):262-268. doi: 10.1097/FJC.0000000000000189
[17]	Huang LL, Nikolic-Paterson DJ, Ma FY, et al. Aldosterone induces kidney fibroblast proliferation via activation of growth factor receptors and PI3K/MAPK signaling[J]. Nephron Exp Nephrol, 2012, 120(4):e115-e122. doi: 10.1159/000339500

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Analysis of relationship between aldosterone level changes and renal function during perioperative period of renal transplantation

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