Volume 7 Issue 2
Mar.  2016
Turn off MathJax
Article Contents
Article Navigation >  ORGAN TRANSPLANTATION  > 2016  >  7(2): 111-114
Wang Yongcui, Sun Liying, Zhu Zhijun, et al. Clinical characteristics and analysis of rotavirus infection after liver transplantation in children[J]. ORGAN TRANSPLANTATION, 2016, 7(2): 111-114. doi: 10.3969/j.issn.1674-7445.2016.02.006
Citation: Wang Yongcui, Sun Liying, Zhu Zhijun, et al. Clinical characteristics and analysis of rotavirus infection after liver transplantation in children[J]. ORGAN TRANSPLANTATION, 2016, 7(2): 111-114. doi: 10.3969/j.issn.1674-7445.2016.02.006
shu

Clinical characteristics and analysis of rotavirus infection after liver transplantation in children

doi: 10.3969/j.issn.1674-7445.2016.02.006

  • Tianjin Medical University, Tianjin 300070, China

More Information
  • Corresponding author: Sun Liying, Email:sunxlx@outlook.com
  • Received Date: 2015-12-15
    Available Online: 2021-01-19
  • Publish Date: 2016-03-15
    Abstract
  •   Objective  To summarize the clinical characteristics and treatment of rotavirus infection after liver transplantation in children.  Methods  Thirty nine children undergoing liver transplantation in Beijing Friendship Hospital affiliated to Capital Medical University from October to December 2014 were retrospectively analyzed. And 6 cases were infected with rotavirus after liver transplantation. Characteristics of clinical symptoms, complications, treatments and prognosis in these six children were retrospectively analyzed.  Results  Six cases were diagnosed with rotavirus infection at 8-197 d after liver transplantation with a median time of 22 d, 3 cases of whom mainly manifested as high fever, diarrhea and vomiting and the remaining 3 presenting with diarrhea. The longer interval time between rotavirus infection and liver transplantation was, the slighter degree of rotavirus infection-related symptoms was. Among 6 cases, 5 cases were complicated with EB virus, cytomegalovirus or respiratory syncytial virus, and 2 cases were complicated with abnormal liver or heart function. The main treatment was decreasing the dose of FK506. Gamma globulin was administered in partial affected children to enhance immunity. Effective therapy was delivered to regulate intestinal tract bacterial colony and relieve diarrhea. All children recovered after oral use of antibiotics and supporting therapy using fluid infusion. Two cases complicated with severe cardiac and liver function abnormality were healed after expectant treatment.  Conclusions  Rotavirus infection-related symptoms are relatively severe after liver transplantation in children, occasionally complicated with cardiac and liver function injury, which can gradually return to normal after efficacious therapy.

     

    • FullText(HTML)
  • loading
    • References(20)
  • [1]
    Chen SC, Tan LB, Huang LM, et al. Rotavirus infection and the current status of rotavirus vaccines[J]. J Formos Med Assoc, 2012, 111(4):183-193. doi: 10.1016/j.jfma.2011.09.024
    [2]
    任江萍, 陈恩富.轮状病毒流行病学与疫苗研究进展[J].浙江预防医学, 2015, 27(8):801-804. http://www.cnki.com.cn/Article/CJFDTOTAL-ZYFX201508012.htm

    Ren JP, Chen EF. Research progress on the epidemiological and vaccine of rotavirus[J]. Zhejiang J Prev Med, 2015, 27(8):801-804. http://www.cnki.com.cn/Article/CJFDTOTAL-ZYFX201508012.htm
    [3]
    叶卉初, 刘玉华.2010-2012年北京地区儿童轮状病毒腹泻的流行病学研究[J].中华实验和临床病毒学杂志, 2012, 26(6):432-434. doi: 10.3760/cma.j.issn.1003-9279.2012.06.010

    Ye HC, Liu YH. Epidemiological study of rotavirus diarrhea in Beijing area from 2010 to 2012[J]. Chin J Exp Clin Virol, 2012, 26(6):432-434. doi: 10.3760/cma.j.issn.1003-9279.2012.06.010
    [4]
    张辉, 李珊珊.2010~2012年泰安市腹泻婴幼儿轮状病毒感染情况分析[J].中国病原学生物杂志, 2013, 8(1):65-66. http://www.cnki.com.cn/Article/CJFDTOTAL-ZISC201301019.htm

    Zhang H, Li SS. Analysis of status of rotavirus infection among infants with diarrhea in Tai'an from 2010 to 2012[J]. J Path Biol, 2013, 8(1):65-66. http://www.cnki.com.cn/Article/CJFDTOTAL-ZISC201301019.htm
    [5]
    Gouandijka-Vasilache I, Manirakiza A, Gody JC, et al. Rotavirus epidemiology in Bangui, Central African Republic, 2008[J]. Emerg Infect Dis, 2014, 20(7):1254-1255. doi: 10.3201/eid2007.131839
    [6]
    Çoban B, Topal B. Evaluation of rotavirus gastroenteritis in children: five years' surveillance in Alanya, Antalya[J]. Turk J Pediatr, 2014, 56(3):280-284. https://www.researchgate.net/publication/267734576_Evaluation_of_rotavirus_gastroenteritis_in_children_five_years%27_surveillance_in_Alanya_Antalya
    [7]
    王鹏, 原新慧, 林谦, 等.南京2011-2013年婴幼儿腹泻轮状病毒分子流行病学研究[J].中华实验和临床病毒学杂志, 2015, 29(3):207-209. doi: 10.3760/cma.j.issn.1003-9279.2015.03.005

    Wang P, Yuan XH, Lin Q, et al. The monitoring on molecular epidemiology of rotavirus diarrhea of children in Nanjing city during 2011-2013[J]. Chin J Exp Clin Virol, 2015, 29(3):207-209. doi: 10.3760/cma.j.issn.1003-9279.2015.03.005
    [8]
    Stelzmueller I, Dunst KM, Hengster P, et al. A cluster of rotavirus enteritis in adult transplant recipients[J]. Transpl Int, 2005, 18(4):470-474. doi: 10.1111/tri.2005.18.issue-4
    [9]
    纪国业, 林冬云, 朱冬卉.不同年龄A群轮状病毒肠炎儿童并发脱水分析[J].热带医学杂志, 2014, 14(1):94-95. http://www.cnki.com.cn/Article/CJFDTOTAL-RDYZ201401027.htm

    Ji GY, Lin DY, Zhu DH. Analysis of dehydration in children with Group A rotavirus enteritis[J]. J Trop Med, 2014, 14(1):94-95. http://www.cnki.com.cn/Article/CJFDTOTAL-RDYZ201401027.htm
    [10]
    Ismaili-Jaha V, Shala M, Azemi M, et al. Characteristics of rotavirus diarrhea in hospitalized children in Kosovo[J]. Mater Sociomed, 2014, 26(5):335-338. https://www.researchgate.net/profile/Luan_Jaha/publication/271534564_Characteristics_of_Rotavirus_Diarrhea_in_Hospitalized_Children_in_Kosovo/links/56436ae608ae54697fb2e4b1.pdf
    [11]
    毕金娥, 张旭光, 熊彪.轮状病毒肠炎合并无热惊厥28例[J].实用医学杂志, 2015, 31(3):515-516. http://www.cnki.com.cn/Article/CJFDTOTAL-SYYZ201503066.htm

    Bi JE, Zhang XG, Xiong B. Rotavirus enteritis with afebrile convulsion in 28 cases[J]. J Pract Med, 2015, 31(3):515-516. http://www.cnki.com.cn/Article/CJFDTOTAL-SYYZ201503066.htm
    [12]
    Salim H, Karyana IP, Sanjaya-Putra IG, et al. Risk factors of rotavirus diarrhea in hospitalized children in Sanglah Hospital, Denpasar: a prospective cohort study[J]. BMC Gastroenterol, 2014, 14:54. doi: 10.1186/1471-230X-14-54
    [13]
    Tumgor G, Arikan C, Aydin U, et al. Effect of rotavirus on serum tacrolimus level in pediatric liver transplant recipients[J]. Pediatr Int, 2008, 50(4):592-593. doi: 10.1111/ped.2008.50.issue-4
    [14]
    Akelma AZ, Kütükoğlu I, Köksal T, et al. Serum transaminase elevation in children with rotavirus gastroenteritis: seven years' experience[J]. Scand J Infect Dis, 2013, 45(5):362-367. doi: 10.3109/00365548.2012.740573
    [15]
    顾蓁, 沈华琴.喂养方式对婴幼儿轮状病毒腹泻的影响[J].临床儿科杂志, 2010, 28(1):57-60. http://www.cnki.com.cn/Article/CJFDTOTAL-LCAK201001022.htm

    Gu Z, Shen HQ. The effects of breast feeding or bottle feeding on infants with rotavirus diarrhea[J]. J Clin Pediatr, 2010, 28(1):57-60. http://www.cnki.com.cn/Article/CJFDTOTAL-LCAK201001022.htm
    [16]
    张颖.婴幼儿轮状病毒性肠炎140例发病特点分析[J].中国医药指南, 2013, 11(25):304-305. http://www.cnki.com.cn/Article/CJFDTOTAL-YYXK201325239.htm

    Zhang Y. 140 cases of infant rotavirus enteritis disease characteristics[J]. Guide Chin Med, 2013, 11(25):304-305. http://www.cnki.com.cn/Article/CJFDTOTAL-YYXK201325239.htm
    [17]
    张标, 佟琳, 易山, 等.二价轮状病毒灭活疫苗的免疫效果评价[J].中华微生物学和免疫学杂志, 2012, 32(9):820-824.

    Zhang B, Tong L, Yi S, et al. The evaluation of immune effects on bivalent rotavirus vaccine[J]. Chin J Microbiol Immunol, 2012, 32(9):820-824.
    [18]
    Banajeh SM, Abu-Asba BA. The epidemiology of all-cause and rotavirus acute gastroenteritis and the characteristics of rotavirus circulating strains before and after rotavirus vaccine introduction in Yemen: analysis of hospital-based surveillance data[J]. BMC Infect Dis, 2015, 15:418. doi: 10.1186/s12879-015-1165-8
    [19]
    Patel NC, Hertel PM, Estes MK, et al. Vaccine-acquired rotavirus in infants with severe combined immunodeficiency[J]. N Engl J Med, 2010, 362(4):314-319. doi: 10.1056/NEJMoa0904485
    [20]
    Marshall GS, Adams GL, Leonardi ML, et al. Immunogenicity, safety, and tolerability of a hexavalent vaccine in infants[J]. Pediatrics, 2015, 136(2):e323-e332. doi: 10.1542/peds.2014-4102
    • Relative Articles
    • Supplements(0)
    • Cited By
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Tables(1)

    Get Citation
    PDF
    XML

    Article Metrics

    Article views (175) PDF downloads(6) Cited by()
    Proportional views
    Related

    WeChat Subscription Account

    Wechat Service Account

    Contact Us
    • Tel：020-38736410
    • Email: organtranspl@163.com
    • Address：The Third Affiliated Hospital of Sun Yat-sen University, No. 600, Tianhe Road, Tianhe District, Guangzhou
    • Editorial Office of Organ Transplantation  粤ICP备2021030844号
    Links

    Supported by: Beijing Renhe Information Technology Co. Ltd    

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return