Relation between donor-recipient HLA mismatching and combined malignant tumor after renal transplantation

Jia Baoxiang; Lin Jun; Wu Junjie; Ma Weiran

doi:10.3969/j.issn.1674-7445.2014.04.007

Volume 5 Issue 4

Jul. 2014

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Jia Baoxiang, Lin Jun, Wu Junjie, et al. Relation between donor-recipient HLA mismatching and combined malignant tumor after renal transplantation[J]. ORGAN TRANSPLANTATION, 2014, 5(4): 227-230. doi: 10.3969/j.issn.1674-7445.2014.04.007

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Relation between donor-recipient HLA mismatching and combined malignant tumor after renal transplantation

doi: 10.3969/j.issn.1674-7445.2014.04.007

Department of Urology, Beijing Friendship Hospital, Affiliated Capital University of Medical Sciences, Beijing 100050, China

Received Date: 2014-03-08
Available Online: 2021-01-19
Publish Date: 2014-07-15

Abstract

Abstract

Objective To study the relation between donor-recipient human leukocyte antigen (HLA) mismatching and combined malignant tumors after renal transplantation. Methods Clinical data of 1 021 patients who received renal transplantation from 1993 to 2009 in Department of Urology of Beijing Friendship Hospital of Affiliated Capital University of Medical Sciences over 5 years and had complete HLA typing were analyzed. In the 1 021 patients after renal transplantation, 928 cases were non-tumor patients and 93 cases were malignant tumor patients. The mismatching data of 3 locus (HLA-A, B and DR) with a total of 6 antigens of the donors and recipients were collected. The relation between donor-recipient HLA mismatching number and postoperative combined malignant tumors was analyzed. And that between genders was also analyzed. Results Malignant tumors occurred in 9.11%(93/1 021)of the patients. The malignant tumor incidences of patients with HLA mismatch of 0-1, 2, 3, 4, 5 and 6 antigens were 14%, 13%, 14%, 6%, 3% and 4% respectively. Patients with HLA over half-matched (0-3 antigens mismatch) had higher incidence of malignant tumors compared with that in patients with HLA less than half matched (4-6 antigens mismatch) (14% vs. 5%;χ²=24.11,P<0.005). In the malignant tumor patients of 0-3 antigens mismatch, 12 cases were males and 54 cases were females. In the patients of 4-6 antigens mismatch, 12 cases were males and 15 cases were females. The proportion of female patients of 0-3 antigens mismatch was higher than that of male patients(χ²=5.60,P<0.025). Conclusions For the renal transplant patients, especially female patients, the lower the HLA mismatching number is, the higher the malignant tumor incidence is.
- Renal transplantation,
- Human leukocyte antigen,
- Matching,
- Malignant tumor,
- Female

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Relation between donor-recipient HLA mismatching and combined malignant tumor after renal transplantation

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