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儿童肾移植术后供者特异性抗体的产生及其影响

陈刚. 儿童肾移植术后供者特异性抗体的产生及其影响[J]. 器官移植, 2022, 13(3): 303-306. doi: 10.3969/j.issn.1674-7445.2022.03.004
引用本文: 陈刚. 儿童肾移植术后供者特异性抗体的产生及其影响[J]. 器官移植, 2022, 13(3): 303-306. doi: 10.3969/j.issn.1674-7445.2022.03.004
Chen Gang. Production and influence of donor specific antibodies after pediatric kidney transplantation[J]. ORGAN TRANSPLANTATION, 2022, 13(3): 303-306. doi: 10.3969/j.issn.1674-7445.2022.03.004
Citation: Chen Gang. Production and influence of donor specific antibodies after pediatric kidney transplantation[J]. ORGAN TRANSPLANTATION, 2022, 13(3): 303-306. doi: 10.3969/j.issn.1674-7445.2022.03.004

儿童肾移植术后供者特异性抗体的产生及其影响

doi: 10.3969/j.issn.1674-7445.2022.03.004
基金项目: 

湖北省技术创新重大项目 2017ACA096

同济医院临床研究领航项目 2019CR108

详细信息
    作者简介:
    通讯作者:

    陈刚, Email: gchentj@163.com

  • 中图分类号: R617, R726

Production and influence of donor specific antibodies after pediatric kidney transplantation

More Information
  • 摘要: 近年来,我国儿童肾移植发展迅速,但仍缺乏足够的有关移植肾长期存活方面的临床数据。成人肾移植术后新生供者特异性抗体(dnDSA)的产生及其介导的慢性排斥反应是影响移植肾长期存活的重要危险因素,但儿童的免疫系统发育尚未完全,其术后dnDSA的产生及其对移植肾和受者的影响可能与成人有所不同。因此,本文就儿童免疫系统的特点、儿童肾移植术后供者特异性抗体(DSA)的产生及影响、儿童肾移植术后DSA产生的危险因素进行总结,并对预防策略提出建议,旨在为提高儿童肾移植术后移植肾的长期存活提供参考,促进我国儿童肾移植的发展。

     

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出版历程
  • 收稿日期:  2022-02-05
  • 网络出版日期:  2022-04-29
  • 刊出日期:  2022-05-15

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