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川芎嗪在器官移植中防治缺血-再灌注损伤的研究进展

王树森 郑越

王树森, 郑越. 川芎嗪在器官移植中防治缺血-再灌注损伤的研究进展[J]. 器官移植, 2018, 9(5): 402-404. doi: 10.3969/j.issn.1674-7445.2018.05.015
引用本文: 王树森, 郑越. 川芎嗪在器官移植中防治缺血-再灌注损伤的研究进展[J]. 器官移植, 2018, 9(5): 402-404. doi: 10.3969/j.issn.1674-7445.2018.05.015
Wang Shusen, Zheng Yue. Research progress of ligustrazine on the prevention and treatment of ischemia-reperfusion injury in organ transplantation[J]. ORGAN TRANSPLANTATION, 2018, 9(5): 402-404. doi: 10.3969/j.issn.1674-7445.2018.05.015
Citation: Wang Shusen, Zheng Yue. Research progress of ligustrazine on the prevention and treatment of ischemia-reperfusion injury in organ transplantation[J]. ORGAN TRANSPLANTATION, 2018, 9(5): 402-404. doi: 10.3969/j.issn.1674-7445.2018.05.015

川芎嗪在器官移植中防治缺血-再灌注损伤的研究进展

doi: 10.3969/j.issn.1674-7445.2018.05.015
基金项目: 

国家自然科学基金 81571555

详细信息
    作者简介:

    王树森, 女, 1993年生, 硕士研究生, 研究方向为临床药学, Email:susyw1@126.com

    通讯作者:

    郑越, 男, 1975年生, 博士, 副主任药师, 研究方向为药理学, Email:zhengy309@126.com

  • 中图分类号: R617

Research progress of ligustrazine on the prevention and treatment of ischemia-reperfusion injury in organ transplantation

  • 摘要: 缺血-再灌注损伤(IRI)是指组织在缺血一段时间又恢复血液供应后, 过量的氧自由基攻击重新获得血液供应的组织细胞。IRI发生在溶栓治疗、器官移植、烧伤等血液循环障碍时。川芎嗪是伞形科蒿木属植物川芎中的主要化学成分, 具有抗血栓、抗IRI、保护心脑血管系统等药理作用。本文对近年来川芎嗪在器官移植中防治肾、肝以及心脏IRI的研究进展做一综述。

     

  • [1] LIU C, LI Z, HUANG Z, et al.Ligustrazine enhances the hypnotic and analgesic effect of ketamine in mice[J].Biol Pharm Bull, 2018, 41(5):690-696.DOI: 10.1248/bpb.b17-00869.
    [2] 张雪霞, 李毅, 周文英.川芎嗪注射液对梗阻性黄疸肾缺血再灌注损伤大鼠肾功能及血清TNF-α的影响[J].中国中医药科技, 2016, 23(6):677-679. http://d.old.wanfangdata.com.cn/Periodical/zgzyykj201606017

    ZHANG XX, LI Y, ZHOU WY.Effects of tetramethylprazine injection on renal function and serum TNF-α of obstructive jaundice rats with kidney ischemia-reperfusion injury[J].Chin J Tradit Med Sci Technol, 2016, 23(6):677-679. http://d.old.wanfangdata.com.cn/Periodical/zgzyykj201606017
    [3] 王娜, 许海江, 赵春玲.川芎嗪对大鼠肾缺血再灌注损伤的保护作用及其机制[J].山西中医学院学报, 2016, 17(4):19-21.DOI: 10.3969/j.issn.1000-7369.2016.04.007.

    WANG N, XU HJ, ZHAO CL.Protective effect and mechanism of tetramethylpyrazine on renal ischemia-reperfusion injury in rats[J].J Shanxi Coll Tradit Chin Med, 2016, 17(4):19-21.DOI: 10.3969/j.issn.1000-7369.2016.04.007.
    [4] WON SJ, KIM JE, CITTOLIN-SANTOS GF, et al.Assessment at the single-cell level identifies neuronal glutathione depletion as both a cause and effect of ischemia-reperfusion oxidative stress[J].J Neurosci, 2015, 35(18):7143-7152.DOI: 10.1523/JNEUROSCI.4826-14.2015.
    [5] 罗梓垠, 宋冬, 陈辉乐, 等.氧化应激在兔肾缺血/再灌注损伤中的作用及川芎嗪干预[J].中国中西医结合肾病杂志, 2015, 16(11):947-950. http://www.wanfangdata.com.cn/details/detail.do?_type=perio&id=zgzxyjhsbzz201511004

    LUO ZY, SONG D, CHEN HL, et al.Effects of oxidative stress on renal ischemia/reperfusion injury in rabbits and intervention with ligustrazine[J].Chin J Integr Tradit West Nephrol, 2015, 16(11):947-950. http://www.wanfangdata.com.cn/details/detail.do?_type=perio&id=zgzxyjhsbzz201511004
    [6] 白鹭.川芎嗪对慢性肾脏病患者血浆内皮素及一氧化氮的影响[J].河南中医, 2018, 38(4):638-641.DOI:10.16367/j.issn.1003-5028.2018. 01.0171.

    BAI L.The influence of ligustrazine on endothelin and nitric oxide of patients with chronic renal disease[J].Henan Tradit Chin Med, 2018, 38(4):638-641.DOI: 10.16367/j.issn.1003-5028.2018.01.0171.
    [7] 周宏宇.大鼠肾缺血再灌注损伤后VEGF的表达及川芎嗪的干预作用[D].广西医科大学, 2017.
    [8] BHATIA-KIŠŠOVÁ I, CAMOUGRAND N.Mitophagy is not induced by mitochondrial damage but plays a role in the regulation of cellular autophagic activity[J].Autophagy, 2013, 9(11):1897-1899.DOI: 10.4161/auto.23979.
    [9] 孙磊, 朱永康.川芎嗪大鼠肝脏/肾脏缺血再灌注损伤中P-选择素表达的影响[J].实用临床医药杂志, 2010, 14(1):19-22.DOI: 10.3969/j.issn.1672-2353.2010.01.007.

    SUN L, ZHU YK.Effects of ligustrazine on P-selectin expression of rats with liver/kidney ischemia-reperfusion injury[J].J Clin Med Pract, 2010, 14(1):19-22.DOI: 10.3969/j.issn.1672-2353.2010.01.007.
    [10] 宋虎, 王振, 杜晨阳.肝缺血再灌注损伤过程中细胞自噬的研究进展[J].天津医科大学学报, 2018, 24(1):87-90. http://d.old.wanfangdata.com.cn/Periodical/tianjykdxxb201801023

    SONG H, WANG Z, DU CY.Research progress on cell autophagy during hepatic ischemia reperfusion injury[J].J Tianjin Med Univ, 2018, 24(1):87-90. http://d.old.wanfangdata.com.cn/Periodical/tianjykdxxb201801023
    [11] 骆助林, 田伏洲, 汤礼军, 等.川芎嗪预处理对大鼠肝缺血再灌注损伤能量代谢的保护作用[J].四川大学学报(医学版), 2012, 43(4):540-542, 546. http://d.old.wanfangdata.com.cn/Periodical/hxykdxxb201204014

    LUO ZL, TIAN FZ, TANG LJ, et al.Protective effect of ligustrazine preconditioning on hepatic energy metabolism in ischemia reperfusion injury of rat[J].J Sichuan Univ (Med Sci Edit), 2012, 43(4):540-542, 546. http://d.old.wanfangdata.com.cn/Periodical/hxykdxxb201204014
    [12] 程颖.机械灌注在肝移植中的应用[J].器官移植, 2016, 7(5):390-393.DOI: 10.3969/j.issn.1674-7445.2016.05.012.

    CHENG Y.Application of mechanical perfusion in liver transplantation[J].Organ Transplant, 2016, 7(5):390-393.DOI: 10.3969/j.issn.1674-7445.2016.05.012.
    [13] 王清卿, 赵鑫, 陈玉超, 等.肝脏缺血再灌注损伤机制及干预的研究进展[J].临床肝胆病杂志, 2016, 32(6):1225-1229.DOI: 10.3969/j.issn.1001-5256.2016.06.049.

    WANG QQ, ZHAO X, CHEN YC, et al.Research advances in mechanisms and intervention of hepatic ischemia-reperfusion injury[J].J Clin Hepatol, 2016, 32(6):1225-1229.DOI: 10.3969/j.issn.1001-5256.2016.06.049.
    [14] CAO J, MIAO Q, MIAO S, et al.Tetramethylpyrazine (TMP) exerts antitumor effects by inducing apoptosis and autophagy in hepatocellular carcinoma[J].Int Immunopharmacol, 2015, 26(1):212-220.DOI: 10.1016/j.intimp.2015.03.028.
    [15] 王策.川芎嗪预处理对大鼠缺血再灌注心肌氧化应激的保护作用[J].中国伤残医学, 2015, 23(15):37-38.DOI: 10.13214/j.cnki.cjotadm.2015.15.024.

    WANG C.Protective effect of ligustrazine preconditioning on myocardial oxidative stress induced by ischemia reperfusion in rats[J].Chin J Trauma Disabil Med, 2015, 23(15):37-38.DOI: 10.13214/j.cnki.cjotadm.2015.15.024.
    [16] 吕磊, 张洁, 殷宇刚, 等.川芎嗪减轻大鼠心肌缺血再灌注损伤后心肌细胞凋亡及其机制研究[J].东南国防医药, 2016, 18(4):361-364.DOI: 10.3969/j.issn.1672-271X.2016.04.007.

    LYU L, ZHANG J, YIN YG, et al.An investigation on the effects of ligustrazine in attenuating apoptosis of myocardial ischemia reperfusion injury in rats and its mechanism[J].Mil Med J Southeast Chin, 2016, 18(4):361-364.DOI: 10.3969/j.issn.1672-271X.2016.04.007.
    [17] LI Y, SONG P, ZHU Q, et al.Liguzinediol improved the heart function and inhibited myocardial cell apoptosis in rats with heart failure[J].Acta Pharmacol Sin, 2014, 35(10):1257-1264.DOI: 10.1038/aps.2014.75.
    [18] ZHANG X, LUO J, HUANG Y, et al.A novel danshensu-tetramethylpyrazine conjugate DT-018 provides cardioprotection by preserving mitochondrial function through the MEF2D/PGC-1α pathway[J].Curr Pharm Des, 2018, 23(39):6062-6070.DOI: 10.2174/1381612823666170817125925.
    [19] 李寅超, 何永侠, 郜凤香, 等.中药有效组分防治心肌缺血再灌注损伤机制研究进展[J].浙江中医药大学学报, 2014, 38(4):501-505. http://d.old.wanfangdata.com.cn/Periodical/zjzyxyxb201404042

    LI YC, HE YX, GAO FX, et al.Research progress on mechanism of effective components of traditional chinese medicine on prevention and treatment of myocardial ischemia reperfusion injury[J].J Zhejiang Chin Med Univ, 2014, 38(4):501-505. http://d.old.wanfangdata.com.cn/Periodical/zjzyxyxb201404042
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出版历程
  • 收稿日期:  2018-07-18
  • 网络出版日期:  2021-01-19
  • 刊出日期:  2018-09-15

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