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摘要: 慢性移植物抗宿主病(cGVHD)是异基因造血干细胞移植(allo-HSCT)的主要后期并发症, 严重影响患者的生存质量, 是导致非复发性死亡的重要原因。cGVHD的治疗一直是移植领域研究的重要内容之一。目前肾上腺皮质激素(激素)是cGVHD的核心治疗药物, 常联用钙神经蛋白抑制剂(CNI)作为一线治疗方案。长期激素治疗往往带来严重不良反应, 而新的治疗方法, 如哺乳动物雷帕霉素靶蛋白抑制剂、利妥昔单抗、间充质干细胞等可避免广泛的免疫毒性, 有治疗cGVHD的巨大潜力。
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