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摘要: 目前, 钙神经蛋白抑制剂(CNI)肾毒性的机制尚未完全明确, 因此需要建立一个良好的动物模型以供研究, 以更好地研究CNI慢性肾毒性的机制和改善CNI肾毒性的途径。本文将大鼠CNI慢性肾毒性模型的发展过程及目前所采用的几种建立模型的方法(正常饮食CNI肾毒性模型、钠耗竭CNI肾毒性模型、单侧肾切除术CNI肾毒性模型)进行综述。
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