The role of neutrophil extracellular trap in the diagnosis and treatment of complications after liver transplantation
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摘要: 肝移植术后并发症的防治对于维护移植肝功能，改善移植受者预后至关重要。中性粒细胞胞外诱捕网（NET）是由中性粒细胞激活后释放到胞外的一种以DNA为骨架，多种组蛋白和颗粒蛋白构成的纤维网状结构，研究表明肝移植术后供肝内中性粒细胞激活和NET的释放参与了包括缺血-再灌注损伤、急性排斥反应、急性肝衰竭和肝细胞癌复发在内的多种肝移植相关并发症的发生。本文将重点探讨NET对肝移植术后并发症的影响，详述NET作为肝移植术后并发症防治潜在靶点的研究进展，以期为肝移植受者术后并发症的防治提供参考，提高临床肝移植疗效，改善肝移植受者预后。
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关键词:
- 肝移植 /
- 中性粒细胞胞外诱捕网 /
- 缺血-再灌注损伤 /
- 急性排斥反应 /
- 急性肝衰竭 /
- 肝细胞癌 /
- 肽基精氨酸脱亚胺酶4（PAD4） /
- 髓过氧化物酶（MPO）
Abstract: Prevention and treatment of complications after liver transplantation play a significant role in maintaining liver graft function and improving clinical prognosis of the recipients. Neutrophil extracellular trap (NET) are fibrous net-like structures composed of DNA as the skeleton and histones and granular proteins released by activated neutrophils. Studies have shown that the activation of neutrophils and the release of NET in donor liver after liver transplantation are involved in the incidence of multiple liver transplantation-related complications including ischemia-reperfusion injury, acute rejection, acute liver failure and recurrence of hepatocellular carcinoma, etc. In this article, the effect of NET on the complications after liver transplantation was mainly assessed, and research progress on NET as a potential target for the prevention and treatment of complications after liver transplantation was reviewed, aiming to provide reference for the prevention and treatment of complications after liver transplantation, enhance clinical efficacy of liver transplantation and improve clinical prognosis of the recipients. -
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