肝移植术后急性肺损伤/急性呼吸窘迫综合征的研究进展

邱伟; 夏旭翔; 章俊鹏; 胡旭焘

doi:10.3969/j.issn.1674-7445.2023.04.004

肝移植术后急性肺损伤/急性呼吸窘迫综合征的研究进展

doi: 10.3969/j.issn.1674-7445.2023.04.004

130000 长春，吉林大学第一医院肝移植中心

基金项目:

吉林省直卫生专项项目 JLSWSRCZX2020-0045

详细信息

作者简介:

通讯作者:
邱伟（ORCID：0009-0000-1279-5742），Email：qiuwei@jlu.edu.cn

中图分类号: R617, R563
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- 文章访问数: 228
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- 被引次数: 0
出版历程
- 收稿日期: 2023-02-04
- 网络出版日期: 2023-07-13
- 刊出日期: 2023-07-15

Research progress on acute lung injury/acute respiratory distress syndrome after liver transplantation

Liver Transplantation Center, the First Hospital of Jilin University, Changchun 130000, China

More Information

Corresponding author: Qiu Wei, Email: qiuwei@jlu.edu.cn

摘要

摘要: 急性肺损伤/急性呼吸窘迫综合症（ALI/ARDS）是肝移植术后常见的并发症，可延长受者术后重症监护室入住时间，影响肝移植手术疗效，病情严重可致受者死亡，临床中引起了肝移植外科医师的高度重视。肝移植术后ALI/ARDS可由肺源性因素（例如机械通气相关肺损伤、肺部感染、误吸等）直接导致，也可由非肺源性因素（例如肺部以外的严重感染、输血、缺血-再灌注损伤等）间接导致。本文对肝移植术后ALI/ARDS的诊断标准及发生情况、发生机制、危险因素、实验室及临床诊断方法以及治疗方法等进行综述，加深对肝移植围手术期ALI/ARDS的理解与认知，以期为肝移植术后ALI/ARDS的诊治提供借鉴。
- 肝移植 /
- 急性肺损伤 /
- 急性呼吸窘迫综合征 /
- 缺血-再灌注损伤 /
- 输血相关性急性肺损伤 /
- 炎症标志物 /
- 肺保护性通气策略 /
- 体外膜肺氧合
Abstract: Acute lung injury/acute respiratory distress syndrome (ALI/ARDS) is a common complication after liver transplantation, which could prolong the length of postoperative intensive care unit stay, affect clinical efficacy of liver transplantation and even lead to the death of recipients. ALI/ARDS has attracted extensive attention from liver transplant surgeons in clinical practice. ALI/ARDS after liver transplantation may be directly caused by pulmonary factors (such as mechanical ventilation-related lung injury, lung infection and aspiration, etc.) or indirectly induced by non-pulmonary factors (such as severe infection outside the lungs, blood transfusion and ischemia-reperfusion injury, etc.). In this article, the diagnostic criteria, incidence, mechanism, risk factors, laboratory and clinical diagnostic approaches and treatment of ALI/ARDS after liver transplantation were reviewed, aiming to deepen the understanding and cognition of ALI/ARDS during the perioperative period of liver transplantation and provide reference for the diagnosis and treatment of ALI/ARDS following liver transplantation.
- Liver transplantation /
- Acute lung injury /
- Acute respiratory distress syndrome /
- Ischemia-reperfusion injury /
- Transfusion-related acute lung injury /
- Inflammatory marker /
- Lung-protective mechanical ventilation /
- Extracorporeal membrane oxygenation

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参考文献(35)

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