Opportunities and challenges of marginal donor liver

Lu Xinyi; Teng Fei; Fu Hong; Zhao Yuanyu; Zhu Liye; Dong Jiayong; Mao Jiaxi; Guo Wenyuan

doi:10.3969/j.issn.1674-7445.2024002

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Lu Xinyi, Teng Fei, Fu Hong, et al. Opportunities and challenges of marginal donor liver[J]. ORGAN TRANSPLANTATION. doi: 10.3969/j.issn.1674-7445.2024002

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Lu Xinyi, Teng Fei, Fu Hong, et al. Opportunities and challenges of marginal donor liver[J]. ORGAN TRANSPLANTATION. doi: 10.3969/j.issn.1674-7445.2024002

Citation:

Lu Xinyi, Teng Fei, Fu Hong, et al. Opportunities and challenges of marginal donor liver[J]. ORGAN TRANSPLANTATION. doi: 10.3969/j.issn.1674-7445.2024002

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Opportunities and challenges of marginal donor liver

doi: 10.3969/j.issn.1674-7445.2024002

1.
Department of Organ Transplantation, the Second Affiliated Hospital of Naval Medical University(Shanghai Changzheng Hospital), Shanghai 200003, China

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Corresponding author: Guo Wenyuan, Email: guowenyuan@smmu.edu.cn Mao Jiaxi, Email: guowenyuan@smmu.edu.cn
Received Date: 2024-01-02
Available Online: 2024-02-29

Abstract

Abstract

With persistent breakthrough and maturity of surgical procedures and postoperative immunosuppressive therapy, the survival rate of liver transplant recipients and grafts has been significantly increased. The shortage of donor liver has become the main obstacle for clinical development of liver transplantation. How to expand the source of donor liver has become an urgent issue. Groundbreaking progresses have been made in the use of common marginal donor livers in clinical liver transplantation, such as elderly donor liver, steatosis donor liver, viral hepatitis donor liver and liver from donation after cardiac death. Nevertheless, multiple restrictions still exist regarding the use of marginal donor liver. Consequently, the definition of marginal donor liver and research progress in the application of common marginal donor livers were reviewed, and the opportunities and challenges for expanding the existing donor pool for liver transplantation were illustrated, aiming to provide reference for expanding the donor pool for clinical liver transplantation and bringing benefits to more patients with end-stage liver disease.
- Liver transplantation,
- Marginal donor liver,
- Elderly,
- Steatosis,
- Viral hepatitis,
- Split liver transplantation,
- Donation after cardiac death,
- Machine perfusion

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References

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Opportunities and challenges of marginal donor liver

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