Kidney xenotransplantation: status quo and development trend of physiological research

Song Jiahua; Yu Yifan; Deng Wenyi; Song Xiangqin; Jin Shuai; Li Tao; Qian Kun; Wang Yi

doi:10.3969/j.issn.1674-7445.2023148

Volume 14 Issue 6

Nov. 2023

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Song Jiahua, Yu Yifan, Deng Wenyi, et al. Kidney xenotransplantation: status quo and development trend of physiological research[J]. ORGAN TRANSPLANTATION, 2023, 14(6): 898-904. doi: 10.3969/j.issn.1674-7445.2023148

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Kidney xenotransplantation: status quo and development trend of physiological research

doi: 10.3969/j.issn.1674-7445.2023148

Song Jiahua^1
,,
Yu Yifan²,
Deng Wenyi³,
Song Xiangqin²,
Jin Shuai²,
Li Tao²,
Qian Kun¹,
Wang Yi^{1, 2, 3
,
,}

1.
Department of Urology, the Second Affiliated Hospital, University of South China, Hengyang 421001, China

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Corresponding author: Wang Yi, Email: wayne0108@126.com
Received Date: 2023-07-29
Accepted Date: 2023-09-19

Available Online: 2023-09-27

Publish Date: 2023-11-09

Abstract

Abstract

Organ transplantation is the most effective treatment for all categories of end-stage organ diseases. To resolve the shortage of donors in organ transplantation, widespread attention has been diverted to xenotransplantation. At present, clinicians mainly highlight the problems related to xenotransplantation rejection and viral infection. The physiology of xenotransplantation has been rarely studied. Kidney performs endocrine function by producing erythropoietin (EPO), renin and activating vitamin D. Although these pathways are usually well preserved in allogeneic transplantation, species-specific differences, especially those between pigs and non-human primates, may still affect the physiological function of transplant organs. In this article, the changes of EPO, renin-angiotensin-aldosterone system (RAAS) and active vitamin D₃ of pig and human after xenotransplantation were illustrated, aiming to provide reference for subclinical research of xenotransplantation.
- Xenotransplantation,
- Kidney transplantation,
- Renin-angiotensin-aldosterone system (RAAS),
- 1, 25-dihydroxy vitamin D₃,
- Erythropoietin (EPO),
- Non-human primate,
- Subclinical research,
- Physiology

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References

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Kidney xenotransplantation: status quo and development trend of physiological research

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