Volume 14 Issue 5
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Zheng Long, Cai Ming. Macrophages and kidney transplantation[J]. ORGAN TRANSPLANTATION, 2023, 14(5): 643-648. doi: 10.3969/j.issn.1674-7445.2023139
Citation: Zheng Long, Cai Ming. Macrophages and kidney transplantation[J]. ORGAN TRANSPLANTATION, 2023, 14(5): 643-648. doi: 10.3969/j.issn.1674-7445.2023139
shu

Macrophages and kidney transplantation

doi: 10.3969/j.issn.1674-7445.2023139

  • Department of Urology, Second Affiliated Hospital of Medical College of Zhejiang University, Hangzhou 310000, China

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  • Author Bio:

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  • Corresponding author: Cai Ming, Email: caiming@zju.edu.cn
  • Received Date: 2023-07-17
  • Accepted Date: 2023-07-21
    • Available Online: 2023-09-08
  • Publish Date: 2023-09-15
    Abstract
  • Kidney transplantation is the optimal treatment for patients with end-stage renal disease, whereas long-term survival of renal allografts remains a challenging issue. Renal ischemia-reperfusion injury (IRI) and rejection of renal allografts are considered as important influencing factors of long-term survival of renal allografts, which are regulated by innate and adaptive immune cells. Macrophages are one type of innate immune cells that could assist initiating adaptive immunity and are divided into M1, M2 and regulatory macrophages. Previous studies have revealed that M1 macrophages may aggravate renal IRI and acute T cell-mediated rejection (TCMR). However, M2 macrophages may mitigate renal IRI and acute TCMR, whereas it is positively correlated with antibody-mediated rejection (AMR). Regulatory macrophages are a special subgroup of macrophages, which may induce immune tolerance in organ transplantation and have promising clinical application prospects and basic scientific research value. In this article, the relationship among macrophage typing, macrophages and renal IRI, rejection of renal allografts, regulatory macrophages and immune tolerance was reviewed, and the potential mechanism was analyzed, aiming to induce changes in macrophage subtypes or eliminate specific subtypes of macrophages, thereby improving clinical prognosis of the recipients and long-term survival of renal allografts.

     

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