Research and application progress in adoptive re-transfusion of regulatory cells in organ transplantation

Wang Ruolin; Jia Ya’nan; Zhu Jiqiao; He Qiang; Li Xianliang

doi:10.3969/j.issn.1674-7445.2023103

Volume 14 Issue 6

Nov. 2023

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Article Navigation > ORGAN TRANSPLANTATION > 2023 > 14(6): 892-897

Wang Ruolin, Jia Ya’nan, Zhu Jiqiao, et al. Research and application progress in adoptive re-transfusion of regulatory cells in organ transplantation[J]. ORGAN TRANSPLANTATION, 2023, 14(6): 892-897. doi: 10.3969/j.issn.1674-7445.2023103

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Research and application progress in adoptive re-transfusion of regulatory cells in organ transplantation

doi: 10.3969/j.issn.1674-7445.2023103

Department of Hepatobiliary-pancreatic-splenic Surgery, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China

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Corresponding author: Li Xianliang, Email: lixianliangbjcy@126.com
Received Date: 2023-06-22
Available Online: 2023-08-25
Publish Date: 2023-11-09

Abstract

Abstract

Rejection and adverse reactions caused by long-term use of immunosuppressants severely affect the survival rate and quality of life of organ transplant recipients. Immune tolerance induction plays a key role in improving the survival rate and quality of life of organ transplant recipients. In recent years, tremendous progress has been achieved in adoptive re-transfusion of regulatory cells. In this article, research progress in regulatory T cell (Treg), myeloid-derived suppressor cell (MDSC) and regulatory B cell (Breg) in animal experiment and clinical application was reviewed, and the main clinical problems of adoptive re-transfusion of regulatory cells, the application of chimeric antigen receptor Treg and the concept of cell therapy in immune evaluation were summarized, aiming to deepen the understanding of regulatory cell therapy, promote the application of regulatory cells in immune tolerance of organ transplantation, and improve clinical efficacy of organ transplantation and the quality of life of recipients.
- Organ transplantation,
- Immune tolerance,
- Rejection,
- Cell therapy,
- Regulatory T cell,
- Regulatory B cell,
- Myeloid-derived suppressor cell,
- Chimeric antigen receptor

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References(44)

References

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Research and application progress in adoptive re-transfusion of regulatory cells in organ transplantation

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