Volume 14 Issue 5
Sep.  2023
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Liu Yanyao, Qin Xiaoyan, Wu Zhongjun. The role of neutrophil extracellular trap in the diagnosis and treatment of complications after liver transplantation[J]. ORGAN TRANSPLANTATION, 2023, 14(5): 736-744. doi: 10.3969/j.issn.1674-7445.2023093
Citation: Liu Yanyao, Qin Xiaoyan, Wu Zhongjun. The role of neutrophil extracellular trap in the diagnosis and treatment of complications after liver transplantation[J]. ORGAN TRANSPLANTATION, 2023, 14(5): 736-744. doi: 10.3969/j.issn.1674-7445.2023093
shu

The role of neutrophil extracellular trap in the diagnosis and treatment of complications after liver transplantation

doi: 10.3969/j.issn.1674-7445.2023093
  • 1.

    Department of Hepatobiliary Surgery, the First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China

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  • Corresponding author: Wu Zhongjun, Email: wzjtcy@126.com
  • Received Date: 2023-04-26
  • Accepted Date: 2023-07-14
    • Available Online: 2023-07-20
  • Publish Date: 2023-09-15
    Abstract
  • Prevention and treatment of complications after liver transplantation play a significant role in maintaining liver graft function and improving clinical prognosis of the recipients. Neutrophil extracellular trap (NET) are fibrous net-like structures composed of DNA as the skeleton and histones and granular proteins released by activated neutrophils. Studies have shown that the activation of neutrophils and the release of NET in donor liver after liver transplantation are involved in the incidence of multiple liver transplantation-related complications including ischemia-reperfusion injury, acute rejection, acute liver failure and recurrence of hepatocellular carcinoma, etc. In this article, the effect of NET on the complications after liver transplantation was mainly assessed, and research progress on NET as a potential target for the prevention and treatment of complications after liver transplantation was reviewed, aiming to provide reference for the prevention and treatment of complications after liver transplantation, enhance clinical efficacy of liver transplantation and improve clinical prognosis of the recipients.

     

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