Research progress on the role of macrophages in renal allograft fibrosis

Ren Difei; Wang Yuchen; Miao Yun

doi:10.3969/j.issn.1674-7445.2023084

Volume 14 Issue 5

Sep. 2023

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Ren Difei, Wang Yuchen, Miao Yun. Research progress on the role of macrophages in renal allograft fibrosis[J]. ORGAN TRANSPLANTATION, 2023, 14(5): 723-729. doi: 10.3969/j.issn.1674-7445.2023084

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Ren Difei, Wang Yuchen, Miao Yun. Research progress on the role of macrophages in renal allograft fibrosis[J]. ORGAN TRANSPLANTATION, 2023, 14(5): 723-729. doi: 10.3969/j.issn.1674-7445.2023084

Citation:

Ren Difei, Wang Yuchen, Miao Yun. Research progress on the role of macrophages in renal allograft fibrosis[J]. ORGAN TRANSPLANTATION, 2023, 14(5): 723-729. doi: 10.3969/j.issn.1674-7445.2023084

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Research progress on the role of macrophages in renal allograft fibrosis

doi: 10.3969/j.issn.1674-7445.2023084

Ren Difei^{1, 2
,},
Wang Yuchen¹,
Miao Yun^{1
,
,}

1.
Department of Organ Transplantation, Nanfang Hospital of Southern Medical University, Guangzhou 510515, China

More Information

Corresponding author: Miao Yun, Email: miaoyunecho@126.com
Received Date: 2023-04-16
Accepted Date: 2023-07-07

Available Online: 2023-07-20

Publish Date: 2023-09-15

Abstract

Abstract

Ischemia-reperfusion injury, rejection, nephrotoxicity caused by calcineurin inhibitors and other factors cause excessive accumulation of renal extracellular matrix after kidney transplantation, which gradually induce renal fibrosis and eventually lead to renal failure. In recent years, the mechanism of macrophages in renal allograft fibrosis has gradually captivated widespread attention. Studies have shown that some drugs like mammalian target of rapamycin inhibitors may mitigate renal allograft fibrosis through the macrophage. In this article, the main pathogenesis and pathophysiological mechanism of renal allograft fibrosis, the role of different macrophages in the progression of renal allograft fibrosis, the infiltration of peripherally-recruited macrophages and renal resident macrophages into renal injury areas, the induction of myofibroblasts by macrophages and potential treatment regimens of macrophage-associated renal allograft fibrosis were reviewed, aiming to provide reference for investigating the role of macrophages in renal allograft fibrosis.
- Fibrosis,
- Kidney transplantation,
- Macrophage,
- Myofibroblasts,
- Ischemia-reperfusion injury,
- Calcineurin inhibitor,
- Inflammation,
- Rejection

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References(50)

References

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Research progress on the role of macrophages in renal allograft fibrosis

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