Current status and prospect of preoperative assessment of heart disease risk in liver transplant recipients

Li Wenlei; Li Guangming

doi:10.3969/j.issn.1674-7445.2023.04.019

Volume 14 Issue 4

Jul. 2023

Turn off MathJax

Article Contents

Article Navigation > ORGAN TRANSPLANTATION > 2023 > 14(4): 605-611

Li Wenlei, Li Guangming. Current status and prospect of preoperative assessment of heart disease risk in liver transplant recipients[J]. ORGAN TRANSPLANTATION, 2023, 14(4): 605-611. doi: 10.3969/j.issn.1674-7445.2023.04.019

Citation:

PDF( 1948 KB)

Current status and prospect of preoperative assessment of heart disease risk in liver transplant recipients

doi: 10.3969/j.issn.1674-7445.2023.04.019

Li Wenlei^,,
Li Guangming^{,
,}

Beijing You'an Hospital Affiliated to Capital Medical University, Beijing 100069, China

Received Date: 2023-05-07
Available Online: 2023-07-13
Publish Date: 2023-07-15

Abstract

Abstract

With the changes of the disease spectrum of liver transplantation and organ allocation system, more and more patients complicated with cardiovascular complications have entered the waiting list for liver transplantation. However, surgical stress, severe infection and adverse reactions of immunosuppressive drugs will significantly increase the risk of postoperative cardiac complications and affect the short-and long-term survival of the recipients. Therefore, comprehensive evaluation of cardiac structure and function of the recipients before liver transplantation is of significance for improving clinical prognosis of the recipients. In this article, the main causes for the increased risk of heart disease during the perioperative period of liver transplantation, the time and methods of heart disease risk assessment for liver transplant recipients were reviewed, and existing assessment approaches for common heart diseases before liver transplantation were illustrated, aiming to provide reference for further reducing the incidence of heart complications after liver transplantation, improving the survival rates of grafts and recipients and enhancing clinical prognosis.
- Liver transplantation,
- Heart disease,
- Coronary artery disease,
- Heart failure,
- Arrhythmia,
- Cardiac magnetic resonance imaging,
- Coronary computed tomography angiography,
- Single-photon emission computed tomography

FullText(HTML)

References(46)

References

[1]	IZZY M, FORTUNE BE, SERPER M, et al. Management of cardiac diseases in liver transplant recipients: comprehensive review and multidisciplinary practice-based recommendations[J]. Am J Transplant, 2022, 22(12): 2740-2758. DOI: 10.1111/ajt.17049.
[2]	CASE BC, YANG M, QAMER SZ, et al. Pre-operative cardiovascular testing before liver transplantation[J]. Am J Cardiol, 2021, 152: 132-137. DOI: 10.1016/j.amjcard.2021.04.012.
[3]	KOSHY AN, GOW PJ, HAN HC, et al. Sudden cardiac death following liver transplantation: incidence, trends and risk predictors[J]. Int J Cardiol, 2021, 327: 171-174. DOI: 10.1016/j.ijcard.2020.11.038.
[4]	BARMAN PM, VANWAGNER LB. Cardiac risk assessment in liver transplant candidates: current controversies and future directions[J]. Hepatology, 2021, 73(6): 2564-2576. DOI: 10.1002/hep.31647.
[5]	VILLERET F, DHARANCY S, ERARD D, et al. Liver transplantation for NAFLD cirrhosis: age and recent coronary angioplasty are major determinants of survival[J]. Liver Int, 2022, 42(11): 2428-2441. DOI: 10.1111/liv.15385.
[6]	靳婕华, 黄缘. 肝移植治疗非酒精性脂肪性肝病的现状[J/CD]. 实用器官移植电子杂志, 2022, 10(2): 152-157. DOI: 10.3969/j.issn.2095-5332.2022.02.013. JIN JH, HUANG Y. Current status of liver transplantation in the treatment of nonalcoholic fatty liver disease[J/CD]. Pract J Organ Transplant (Electr Vers), 2022, 10(2): 152-157. DOI: 10.3969/j.issn.2095-5332.2022.02.013.
[7]	IZZY M, SOLDATOVA A, SUN X, et al. Cirrhotic cardiomyopathy predicts posttransplant cardiovascular disease: revelations of the new diagnostic criteria[J]. Liver Transpl, 2021, 27(6): 876-886. DOI: 10.1002/lt.26000.
[8]	IZZY M, VANWAGNER LB, LIN G, et al. Redefining cirrhotic cardiomyopathy for the modern era[J]. Hepatology, 2020, 71(1): 334-345. DOI: 10.1002/hep.30875.
[9]	FELTRACCO P, BARBIERI S, CAROLLO C, et al. Early circulatory complications in liver transplant patients[J]. Transplant Rev (Orlando), 2019, 33(4): 219-230. DOI: 10.1016/j.trre.2019.06.005.
[10]	MALIK MU, RUSSELL SD, PUSTAVOITAU A, et al. The predictors of post-transplant coronary events among liver transplant recipients[J]. Hepatol Int, 2016, 10(6): 974-982. DOI: 10.1007/s12072-016-9742-5.
[11]	VANWAGNER LB, NING H, WHITSETT M, et al. A point-based prediction model for cardiovascular risk in orthotopic liver transplantation: the CAR-OLT score[J]. Hepatology, 2017, 66(6): 1968-1979. DOI: 10.1002/hep.29329.
[12]	LEVY PE, KHAN SS, VANWAGNER LB. Cardiac evaluation of the kidney or liver transplant candidate[J]. Curr Opin Organ Transplant, 2021, 26(1): 77-84. DOI: 10.1097/MOT.0000000000000838.
[13]	KHURMI NS, CHANG YH, ERIC STEIDLEY D, et al. Hospitalizations for cardiovascular disease after liver transplantation in the United States[J]. Liver Transpl, 2018, 24(10): 1398-1410. DOI: 10.1002/lt.25055.
[14]	VANWAGNER LB, HOLL JL, MONTAG S, et al. Blood pressure control according to clinical practice guidelines is associated with decreased mortality and cardiovascular events among liver transplant recipients[J]. Am J Transplant, 2020, 20(3): 797-807. DOI: 10.1111/ajt.15706.
[15]	XIAO J, YONG JN, NG CH, et al. A meta-analysis and systematic review on the global prevalence, risk factors, and outcomes of coronary artery disease in liver transplantation recipients[J]. Liver Transpl, 2022, 28(4): 689-699. DOI: 10.1002/lt.26331.
[16]	KAKAR P, GUBITOSA J, GERULA C. Echocardiography in the liver transplant patient[J]. Curr Cardiol Rep, 2021, 23(8): 110. DOI: 10.1007/s11886-021-01531-1.
[17]	PATEL SS, LIN FP, RODRIGUEZ VA, et al. The relationship between coronary artery disease and cardiovascular events early after liver transplantation[J]. Liver Int, 2019, 39(7): 1363-1371. DOI: 10.1111/liv.14092.
[18]	SATAPATHY SK, VANATTA JM, HELMICK RA, et al. Outcome of liver transplant recipients with revascularized coronary artery disease: a comparative analysis with and without cardiovascular risk factors[J]. Transplantation, 2017, 101(4): 793-803. DOI: 10.1097/TP.0000000000001647.
[19]	WEBERLING LD, LOSSNITZER D, FREY N, et al. Coronary computed tomography vs. cardiac magnetic resonance imaging in the evaluation of coronary artery disease[J]. Diagnostics (Basel), 2022, 13(1): 125. DOI: 10.3390/diagnostics13010125.
[20]	CHENG XS, VANWAGNER LB, COSTA SP, et al. Emerging evidence on coronary heart disease screening in kidney and liver transplantation candidates: a scientific statement from the american heart association: endorsed by the american society of transplantation[J]. Circulation, 2022, 146(21): e299-e324. DOI: 10.1161/CIR.0000000000001104.
[21]	DE GASPERI A, SPAGNOLIN G, ORNAGHI M, et al. Preoperative cardiac assessment in liver transplant candidates[J]. Best Pract Res Clin Anaesthesiol, 2020, 34(1): 51-68. DOI: 10.1016/j.bpa.2020.02.002.
[22]	杨鑫, 杨叶, 张婉婷, 等. 基于CT-FFR在冠状动脉功能性狭窄评估中的应用进展[J]. 影像研究与医学应用, 2023, 7(4): 18-20. DOI: 10.3969/j.issn.2096-3807.2023.04.006. YANG X, YANG Y, ZHANG WT, et al. Progress based on the application of CT-FFR in the evaluation of functional stenosis of coronary arteries[J]. J Imaging Res Med Appl, 2023, 7(4): 18-20. DOI: 10.3969/j.issn.2096-3807.2023.04.006.
[23]	KEMMER N, CASE J, CHANDNA S, et al. The role of coronary calcium score in the risk assessment of liver transplant candidates[J]. Transplant Proc, 2014, 46(1): 230-233. DOI: 10.1016/j.transproceed.2013.09.035.
[24]	SHARMA V, KLEB C, SHETH C, et al. Cardiac considerations in liver transplantation[J]. Cleve Clin J Med, 2022, 89(1): 46-55. DOI: 10.3949/ccjm.89a.21006.
[25]	CANTONI V, GREEN R, ACAMPA W, et al. Diagnostic performance of myocardial perfusion imaging with conventional and CZT single-photon emission computed tomography in detecting coronary artery disease: a metaanalysis[J]. J Nucl Cardiol, 2021, 28(2): 698-715. DOI: 10.1007/s12350-019-01747-3.
[26]	DANAD I, SZYMONIFKA J, TWISK JWR, et al. Diagnostic performance of cardiac imaging methods to diagnose ischaemia-causing coronary artery disease when directly compared with fractional flow reserve as a reference standard: a meta-analysis[J]. Eur Heart J, 2017, 38(13): 991-998. DOI: 10.1093/eurheartj/ehw095.
[27]	KASSAB K, DOUKKY R. Cardiac imaging for the assessment of patients being evaluated for liver transplantation[J]. J Nucl Cardiol, 2022, 29(3): 1078-1090. DOI: 10.1007/s12350-021-02591-0.
[28]	DUVALL WL, SINGHVI A, TRIPATHI N, et al. SPECT myocardial perfusion imaging in liver transplantation candidates[J]. J Nucl Cardiol, 2020, 27(1): 254-265. DOI: 10.1007/s12350-018-1388-3.
[29]	TORⅡ R, YACOUB MH. CT-based fractional flow reserve: development and expanded application[J]. Glob Cardiol Sci Pract, 2021, 2021(3): e202120. DOI: 10.21542/gcsp.2021.20.
[30]	PATEL SS, NABI E, GUZMAN L, et al. Coronary artery disease in decompensated patients undergoing liver transplantation evaluation[J]. Liver Transpl, 2018, 24(3): 333-342. DOI: 10.1002/lt.25012.
[31]	BONOU M, MAVROGENI S, KAPELIOS CJ, et al. Preoperative evaluation of coronary artery disease in liver transplant candidates: many unanswered questions in clinical practice[J]. Diagnostics (Basel), 2021, 11(1): 75. DOI: 10.3390/diagnostics11010075.
[32]	ROMERO-CRISTÓBAL M, MOMBIELA T, CABALLERO A, et al. Clinical utility of a riskadapted protocol for the evaluation of coronary artery disease in liver transplant recipients[J]. Liver Transpl, 2019, 25(8): 1177-1186. DOI: 10.1002/lt.25493.
[33]	陈欣, 陈琳. 肝硬化心肌病发病机制与临床相关性研究现况[J]. 肝脏, 2023, 28(1): 121-124. DOI: 10.3969/j.issn.1008-1704.2023.01.029. CHEN X, CHEN L. Current status of research on the pathogenesis and clinical relevance of cardiomyopathy with liver cirrhosis[J]. Chin Hepatol, 2023, 28(1): 121-124. DOI: 10.3969/j.issn.1008-1704.2023.01.029.
[34]	MOON YJ, KWON HM, JUNG KW, et al. Risk stratification of myocardial injury after liver transplantation in patients with computed tomographic coronary angiography-diagnosed coronary artery disease[J]. Am J Transplant, 2019, 19(7): 2053-2066. DOI: 10.1111/ajt.15263.
[35]	KASKI JC, CREA F, GERSH BJ, et al. Reappraisal of ischemic heart disease[J]. Circulation, 2018, 138(14): 1463-1480. DOI: 10.1161/CIRCULATIONAHA.118.031373.
[36]	徐强, 方玮, 孙高亚, 等. 肝硬化心肌病诊断与治疗研究进展[J]. 肝脏, 2022, 27(3): 267-270. DOI: 10.3969/j.issn.1008-1704.2022.03.004. XU Q, FANG W, SUN GY, et al. Research progress in the diagnosis and treatment of liver cirrhosis cardiomyopathy[J]. Chin Hepatol, 2022, 27(3): 267-270. DOI: 10.3969/j.issn.1008-1704.2022.03.004.
[37]	赵敏竹, 杨晋辉, 李玉婷. 肝硬化心肌病的病理特征、发病机制及诊疗进展[J]. 山东医药, 2022, 62(22): 91-94. DOI: 10.3969/j.issn.1002-266X.2022.22.023. ZHAO MZ, YANG JH, LI YT. Pathological characteristics, pathogenesis, and diagnosis and treatment progress of liver cirrhosis cardiomyopathy[J]. Shandong Med J, 2022, 62(22): 91-94. DOI: 10.3969/j.issn.1002-266X.2022.22.023.
[38]	张辉辉, 朱好辉, 张喜君, 等. 压力-应变环定量评价乙型肝炎肝硬化患者左室整体心肌做功[J]. 中华肝脏病杂志, 2022, 30(4): 402-406. DOI: 10.3760/cma.j.cn501113-20210628-00305. ZHANG HH, ZHU HH, ZHANG XJ, et al. Quantitative evaluation of global left ventricular myocardial work in patients with hepatitis B cirrhosis by pressure-strain loop[J]. Chin J Hepatol, 2022, 30(4): 402-406. DOI: 10.3760/cma.j.cn501113-20210628-00305.
[39]	陈宗坤, 孙静, 莱智勇, 等. 肝硬化心肌病诊断评估分析[J]. 中西医结合心脑血管病杂志, 2021, 19(15): 2558-2563. DOI: 10.12102/j.issn.1672-1349.2021.15.013. CHEN ZK, SUN J, LAI ZY, et al. Diagnosis and evaluation analysis of cirrhotic cardiomyopathy[J]. Chin J Integr Med Cardio Cerebrovasc Dis, 2021, 19(15): 2558-2563. DOI: 10.12102/j.issn.1672-1349.2021.15.013.
[40]	DOUGLAS PS, DE BRUYNE B, PONTONE G, et al. 1-year outcomes of FFRCT-guided care in patients with suspected coronary disease: the PLATFORM study[J]. J Am Coll Cardiol, 2016, 68(5): 435-445. DOI: 10.1016/j.jacc.2016.05.057.
[41]	TESCHE C, DE CECCO CN, ALBRECHT MH, et al. Coronary CT angiography-derived fractional flow reserve[J]. Radiology, 2017, 285(1): 17-33. DOI: 10.1148/radiol.2017162641.
[42]	张澍. 精彩2022: 心律失常领域10大研究回顾[J]. 中华心律失常学杂志, 2023, 27(1): 1-4. DOI: 10.3760/cma.j.cn113859-20230106-00001. ZHANG S. Top 10 studies of cardiac arrhythmia in 2022[J]. Chin J Card Arrhythm, 2023, 27(1): 1-4. DOI: 10.3760/cma.j.cn113859-20230106-00001.
[43]	SO WZ, TAN FL, TAN DJH, et al. A systematic review and meta-analysis on the impact of pre-existing and newonset atrial fibrillation on outcomes before and after liver transplantation[J]. Dig Liver Dis, 2022, 54(5): 614-621. DOI: 10.1016/j.dld.2021.11.011.
[44]	KOSHY AN, KO J, FAROUQUE O, et al. Effect of QT interval prolongation on cardiac arrest following liver transplantation and derivation of a risk index[J]. Am J Transplant, 2021, 21(2): 593-603. DOI: 10.1111/ajt.16145.
[45]	BERNARDI M, MAGGIOLI C, DIBRA V, et al. QT interval prolongation in liver cirrhosis: innocent bystander or serious threat?[J]. Expert Rev Gastroenterol Hepatol, 2012, 6(1): 57-66. DOI: 10.1586/egh.11.86.
[46]	LEE SH, PARK M, PARK KM, et al. Corrected QT interval on the electrocardiogram after liver transplantation: surrogate marker of poor clinical outcomes?[J]. PLoS One, 2018, 13(10): e0206463. DOI: 10.1371/journal.pone.0206463.

Relative Articles

Supplements(0)

Cited By

Proportional views

Proportional views

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

Figures(1)

Get Citation

PDF

XML

Article Metrics

Article views (150) PDF downloads(39)

Current status and prospect of preoperative assessment of heart disease risk in liver transplant recipients

doi: 10.3969/j.issn.1674-7445.2023.04.019

Abstract

References

Proportional views

Catalog

通讯作者: 陈斌, bchen63@163.com

Article Metrics

Proportional views

Related

Current status and prospect of preoperative assessment of heart disease risk in liver transplant recipients

doi: 10.3969/j.issn.1674-7445.2023.04.019

Abstract

References

Proportional views

Catalog

通讯作者: 陈斌, bchen63@163.com

Article Metrics

Proportional views

Related

Export File

Citation

Format

Content