Research status on the role of heat shock protein in organ transplantation

Cheng Xuechao; Song Yongxiang; Meng Hui

doi:10.3969/j.issn.1674-7445.2023.03.019

Volume 14 Issue 3

May 2023

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Cheng Xuechao, Song Yongxiang, Meng Hui. Research status on the role of heat shock protein in organ transplantation[J]. ORGAN TRANSPLANTATION, 2023, 14(3): 455-460. doi: 10.3969/j.issn.1674-7445.2023.03.019

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Research status on the role of heat shock protein in organ transplantation

doi: 10.3969/j.issn.1674-7445.2023.03.019

Department of Cardiothoracic Surgery, the Fifth Affiliated Hospital of Zunyi Medical University, Zhuhai 519100, China

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Corresponding author: Meng Hui, Email: mhgl2008@163.com
Received Date: 2022-12-29
Publish Date: 2023-05-15

Abstract

Abstract

Organ transplantation is an effective treatment for multiple end-stage diseases. In recent years, rapid progress has been made in the field of organ transplantation, which has been widely accepted and applied in clinical practice. However, low utilization rate of donors and high postoperative complications remain to be urgently resolved. Heat shock protein (HSP) is a category of protein family induced by heat shock or other stressors. Upon stress stimulation, HSP plays an anti-inflammation, anti-oxidation and anti-apoptosis role in mitigating the stress-induced damage. HSP is also involved in the processes of promoting immune response and anti-rejection, etc. Organ transplantation, as a stress stimulus, could induce HSP to function in the process of organ transplantation through many patterns, thereby alleviating the allograft damage, improving the utilization rate of donors and prolonging the postoperative survival of recipients. In this article, research status on the role of HSP in lung transplantation, heart transplantation, liver transplantation and kidney transplantation were reviewed, aiming to provide reference for donor protection of organ transplantation and treatment of postoperative complications.
- Heat shock protein,
- Organ transplantation,
- Lung transplantation,
- Heart transplantation,
- Liver transplantation,
- Kidney transplantation,
- Organ protection,
- Ischemia-reperfusion injury

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References(38)

References

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Research status on the role of heat shock protein in organ transplantation

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