Treatment of severe aplastic anemia and hematopoietic stem cell transplantation

Li Yanjuan; Zhang Liansheng; Li Lijuan

doi:10.3969/j.issn.1674-7445.2023.03.017

Volume 14 Issue 3

May 2023

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Li Yanjuan, Zhang Liansheng, Li Lijuan. Treatment of severe aplastic anemia and hematopoietic stem cell transplantation[J]. ORGAN TRANSPLANTATION, 2023, 14(3): 442-448. doi: 10.3969/j.issn.1674-7445.2023.03.017

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Treatment of severe aplastic anemia and hematopoietic stem cell transplantation

doi: 10.3969/j.issn.1674-7445.2023.03.017

Department of Hematology, Lanzhou University Second Hospital, the Second Clinical Medical College of Lanzhou University, Lanzhou 730000, China

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Corresponding author: Zhang Liansheng, Email: zhanglsh@lzu.edu.cn; Li Lijuan, Email: doctorjuan@sina.com
Received Date: 2023-01-18
Publish Date: 2023-05-15

Abstract

Abstract

Severe aplastic anemia (SAA) is a severe bone marrow failure syndrome caused by multiple causes, which is clinically manifested with severe anemia, infection and bleeding. The complex pathogenesis of SAA has not been fully understood. SAA is characterized with acute onset, severe disease condition and rapid progression. At present, with the in-depth study of SAA and the improvement of diagnosis and treatment, the therapeutic strategy for SAA has been evolved from classical immunosuppressive therapy based on antithymocyte globulin and cyclosporine to the application of thrombopoietin receptor agonist and combined treatment based on allogeneic hematopoietic stem cell transplantation, which may promote the reconstruction of hematopoietic function of SAA patients to varying degree and significantly improve survival and clinical prognosis, becoming the research hotspot of SAA treatment. In this article, new advances in the treatment of SAA at home and abroad were reviewed.

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References

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Treatment of severe aplastic anemia and hematopoietic stem cell transplantation

doi: 10.3969/j.issn.1674-7445.2023.03.017

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Treatment of severe aplastic anemia and hematopoietic stem cell transplantation

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