Volume 14 Issue 3
May  2023
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Article Navigation >  ORGAN TRANSPLANTATION  > 2023  >  14(3): 427-434
Huang Kezhi, Li Yiqing, Xie Shaofan, et al. Successful treatment of acute leukemia by secondary transplantation after the first haploidentical hematopoietic stem cell transplantation failure[J]. ORGAN TRANSPLANTATION, 2023, 14(3): 427-434. doi: 10.3969/j.issn.1674-7445.2023.03.015
Citation: Huang Kezhi, Li Yiqing, Xie Shaofan, et al. Successful treatment of acute leukemia by secondary transplantation after the first haploidentical hematopoietic stem cell transplantation failure[J]. ORGAN TRANSPLANTATION, 2023, 14(3): 427-434. doi: 10.3969/j.issn.1674-7445.2023.03.015
shu

Successful treatment of acute leukemia by secondary transplantation after the first haploidentical hematopoietic stem cell transplantation failure

doi: 10.3969/j.issn.1674-7445.2023.03.015

  • Department of Hematology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Guangzhou 510120, China

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  • Corresponding author: Nie Danian, Email: niedn@mail.sysu.edu.cn
  • Received Date: 2023-01-08
  • Publish Date: 2023-05-15
    Abstract
  •   Objective  To evaluate the feasibility of secondary transplantation for patients with acute leukemia after failure of the first haploidentical hematopoietic stem cell transplantation.  Methods  Two acute leukemia patients underwent the first haploidentical hematopoietic stem cell transplantation from two donors with thalassemia, and the number of collected CD34+ cells was 2.57×106/kg and 1.99×106/kg per donor, respectively. The first haploidentical hematopoietic stem cell transplantation failed. Secondary transplantation was performed from two non-thalassemia donors, and the number of collected CD34+ cells was 4.28×106/kg and 5.75×106/kg per donor, respectively. A reduced-intensity conditioning regimen consisting of fludarabine (Flu), busulfan (Bu) and antithymocyte globulin (ATG) was adopted for the secondary transplantation.  Results  For two recipients, the time of secondary transplantation of neutrophil and platelet was +12 d and +10 d, +10 d and +10 d, respectively. Up to the final follow-up (+1 062 d and +265 d after secondary transplantation), the primary diseases of both two recipients have been completely relieved without evident post-transplantation complications.  Conclusions  Secondary transplantation with reduced-intensity conditioning regimen may successfully treat acute leukemia after failure of the first haploidentical hematopoietic stem cell transplantation.

     

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