Research progress on the role of macrophages in post-transplantation chronic rejection

Ren Difei; Liao Tao; Miao Yun

doi:10.3969/j.issn.1674-7445.2023.03.006

Volume 14 Issue 3

May 2023

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Ren Difei, Liao Tao, Miao Yun. Research progress on the role of macrophages in post-transplantation chronic rejection[J]. ORGAN TRANSPLANTATION, 2023, 14(3): 358-363. doi: 10.3969/j.issn.1674-7445.2023.03.006

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Research progress on the role of macrophages in post-transplantation chronic rejection

doi: 10.3969/j.issn.1674-7445.2023.03.006

Department of Organ Transplantation, Nanfang Hospital of Southern Medical University, Guangzhou 510515, China

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Corresponding author: Miao Yun, Email: miaoyunecho@126.com
Received Date: 2022-12-04
Publish Date: 2023-05-15

Abstract

Abstract

Organ transplantation is the optimal treatment for end-stage organ failure. Nevertheless, rejection remains an important factor affecting the allograft survival. At present, acute rejection may be effectively treated, whereas no effective interventions are available for post-transplantation chronic rejection. Long-term chronic rejection may lead to graft failure and severely affect long-term survival rate of allografts. In recent years, the role of macrophages in post-transplantation chronic rejection has gradually captivated increasing attention. In this article, main pathological changes of chronic rejection, the diversity and functional differences of macrophages involved in chronic rejection, and the role and mechanism of macrophages in chronic rejection were reviewed, and research progresses on macrophage-related treatment for chronic rejection were summarized, aiming to provide reference for the study of macrophages in post-transplantation chronic rejection.
- Organ transplantation,
- Chronic rejection,
- Macrophage,
- Fibrosis,
- Inflammation,
- Graft vascular disease,
- Repair,
- Actin

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References(44)

References

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Research progress on the role of macrophages in post-transplantation chronic rejection

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