Volume 14 Issue 1
Jan.  2023
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Wang Xiaowen, Zheng Zhe, Huang Jie. Clinical research progress and mechanism on myocardial injury in hearts from donors with stroke[J]. ORGAN TRANSPLANTATION, 2023, 14(1): 42-48. doi: 10.3969/j.issn.1674-7445.2023.01.005
Citation: Wang Xiaowen, Zheng Zhe, Huang Jie. Clinical research progress and mechanism on myocardial injury in hearts from donors with stroke[J]. ORGAN TRANSPLANTATION, 2023, 14(1): 42-48. doi: 10.3969/j.issn.1674-7445.2023.01.005
shu

Clinical research progress and mechanism on myocardial injury in hearts from donors with stroke

doi: 10.3969/j.issn.1674-7445.2023.01.005

  • Department of Cardiothoracic Surgery, the First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China

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    Abstract
  • At present, the heart of donor from donation after brain death are the primary organ sources for heart transplantation. After brain death, severe hemodynamic changes and a series of organ functional changes will occur, thereby leading to the functional damage or even loss of tissues and organs, especially the heart. Intimate relationship and interaction have been found in the physiology and pathophysiology between nervous and cardiovascular systems. After stroke, autonomic nervous disorder, neuroendocrine disorder and intense and persistent inflammatory reaction could be caused by the brain-heart axis reaction, leading to stroke-induced cardiac injuries, such as sympathetic storm, catecholamine storm, inflammatory storm, etc. In this article, research progresses on the mechanism of myocardial injury in heart from donors with stroke and the effect on clinical efficacy and prognosis after heart transplantation were reviewed, aiming to provide reference for clinical practice and subsequent research.

     

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