Development status and new challenges of heart transplantation

Chen Liangwan; Li Qianzhen; Dai Xiaofu; Fang Guanhua; Qiu Zhihuang

doi:10.3969/j.issn.1674-7445.2023.01.004

Volume 14 Issue 1

Jan. 2023

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Chen Liangwan, Li Qianzhen, Dai Xiaofu, et al. Development status and new challenges of heart transplantation[J]. ORGAN TRANSPLANTATION, 2023, 14(1): 31-41. doi: 10.3969/j.issn.1674-7445.2023.01.004

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Chen Liangwan, Li Qianzhen, Dai Xiaofu, et al. Development status and new challenges of heart transplantation[J]. ORGAN TRANSPLANTATION, 2023, 14(1): 31-41. doi: 10.3969/j.issn.1674-7445.2023.01.004

Citation:

Chen Liangwan, Li Qianzhen, Dai Xiaofu, et al. Development status and new challenges of heart transplantation[J]. ORGAN TRANSPLANTATION, 2023, 14(1): 31-41. doi: 10.3969/j.issn.1674-7445.2023.01.004

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Development status and new challenges of heart transplantation

doi: 10.3969/j.issn.1674-7445.2023.01.004

Department of Cardiovascular Surgery, Fujian Medical University Union Hospital, Fuzhou 350001, China

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Corresponding author: Chen Liangwan, Email: chenliangwan@tom.com
Received Date: 2022-11-11
Available Online: 2023-01-17
Publish Date: 2023-01-15

Abstract

Abstract

Heart transplantation is the primary therapeutic option for patients with end-stage heart failure. The shortage of donors has been the main limiting factor for the increasing quantity of heart transplantation. With persistent updating and introduction of novel technologies, the donor pool has been increasingly expanded, such as using the heart from older donors, donors infected with hepatitis C virus, donors dying from drug overdose or donation after cardiac death (DCD) donors, etc. Meantime, the proportion of recipients with advanced age, multiple organ dysfunction, mechanical circulatory support and human leukocyte antigen antibody sensitization has been significantly increased in recent years. The shortage of donors, complication of recipients' conditions, individualized management of immunosuppressive therapy and prevention and treatment of long-term cardiac allograft vasculopathy are all challenges in the field of heart transplantation. In this article, novel progresses on donor pool expansion, improving the quality of recipients, strengthening the diagnosis and treatment of rejection, and preventing cardiac allograft vasculopathy were reviewed, aiming to prolong the survival and enhance the quality of life of patients with end-stage heart failure on the waiting list or underwent heart transplantation.

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References

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Development status and new challenges of heart transplantation

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