Volume 14 Issue 1
Jan.  2023
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Branch of Organ Transplantation of Chinese Medical Association, Branch of Organ Transplant Physician of Chinese Medical Doctor Association, National Quality Control Center for Human Donated Organ Procurement. Expert consensus on organ donation from patients infected with novel coronavirus in China[J]. ORGAN TRANSPLANTATION, 2023, 14(1): 1-10. doi: 10.3969/j.issn.1674-7445.2023.01.001
Citation: Branch of Organ Transplantation of Chinese Medical Association, Branch of Organ Transplant Physician of Chinese Medical Doctor Association, National Quality Control Center for Human Donated Organ Procurement. Expert consensus on organ donation from patients infected with novel coronavirus in China[J]. ORGAN TRANSPLANTATION, 2023, 14(1): 1-10. doi: 10.3969/j.issn.1674-7445.2023.01.001

Expert consensus on organ donation from patients infected with novel coronavirus in China

doi: 10.3969/j.issn.1674-7445.2023.01.001
  • Received Date: 2023-01-07
    Available Online: 2023-01-17
  • Publish Date: 2023-01-15
  • The spread, prevention and control of novel coronavirus infection and the potential risks and uncertainties of novel coronavirus transmission from donor to recipient have brought serious impacts and great challenges to organ donation and transplantation. There is increasing evidence that the use of non-pulmonary organs (kidney, liver and heart) from novel coronavirus infected donors carries a low risk of transmission, regardless of whether they were symptomatic at the time of acquisition. Delaying organ donation after the death of those who are positive for novel coronavirus antigen or nucleic acid testing, and then waiting until turns negative, will result in the discarding of a significant number of organs that are medically suitable for transplantation. In order to maximally meet the demand for transplantation in patients with end-stage organ failure, Branch of Organ Transplantation of Chinese Medical Association organized relevant experts formulated the "Expert consensus on organ donation from patients infected with novel coronavirus in China" after citizen' s death by taking into account the epidemic situation of novel coronavirus infection in China and the clinical practice of organ donation and transplantation, and by referring to relevant research results and clinical research evidence at home and abroad. It aims to provide recommendations and references for the procurement and application of donor organs from patients infected with novel coronavirus.

     

  • Corresponding authors: Xue Wujun, Email: xwujun126@xjtu.edu.cn
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  • [1]
    AUBERT O, YOO D, ZIELINSKI D, et al. COVID-19 pandemic and worldwide organ transplantation: a population-based study[J]. Lancet Public Health, 2021, 6(10): e709-e719. DOI: 10.1016/S2468-2667(21)00200-0.
    [2]
    RITSCHL PV, NEVERMANN N, WIERING L, et al. Solid organ transplantation programs facing lack of empiric evidence in the COVID-19 pandemic: a By-proxy Society Recommendation Consensus approach[J]. Am J Transplant, 2020, 20(7): 1826-1836. DOI: 10.1111/ajt.15933.
    [3]
    PEGHIN M, GROSSI PA. COVID-19 positive donor for solid organ transplantation[J]. J Hepatol, 2022, 77(4): 1198-1204. DOI: 10.1016/j.jhep.2022.06.021.
    [4]
    BOCK MJ, VAUGHN GR, CHAU P, et al. Organ transplantation using COVID-19-positive deceased donors[J]. Am J Transplant, 2022, 22(9): 2203-2216. DOI: 10.1111/ajt.17145.
    [5]
    DHAND A, OKUMURA K, NABORS C, et al. Solid organ transplantation from COVID positive donors in the United States: analysis of United Network for Organ Sharing database[J]. Transpl Infect Dis, 2022, DOI: 10.1111/tid.13925[Epub ahead of print].
    [6]
    国家卫生健康委办公厅, 中央军委后勤保障部卫生局. 血站新冠病毒感染防控工作指引(第二版)[EB/OL]. [2023-01-05]. http://www.nhc.gov.cn/ylyjs/pqt/202212/2320f33915664959b868d3ac49b91c1c.shtml.
    [7]
    MARTINEZ-REVIEJO R, TEJADA S, CIPRIANO A, et al. Solid organ transplantation from donors with recent or current SARS-CoV-2 infection: a systematic review[J]. Anaesth Crit Care Pain Med, 2022, 41(4): 101098. DOI: 10.1016/j.accpm.2022.101098.
    [8]
    SCHOLD JD, KOVAL CE, WEE A, et al. Utilization and outcomes of deceased donor SARS-CoV-2-positive organs for solid organ transplantation in the United States[J]. Am J Transplant, 2022, 22(9): 2217-2227. DOI: 10.1111/ajt.17126.
    [9]
    国务院应对新型冠状病毒肺炎疫情联防联控机制综合组. 关于进一步优化新冠肺炎疫情防控措施科学精准做好防控工作的通知[A/OL]. [2023-01-05]. http://www.nhc.gov.cn/xcs/zhengcwj/202211/ed9d123bbfe14e738402d846290049ea.shtml.
    [10]
    国务院应对新型冠状病毒肺炎疫情联防联控机制综合组. 关于进一步优化落实新冠肺炎疫情防控措施的通知[EB/OL]. [2023-01-05]. http://www.nhc.gov.cn/xcs/zhengcwj/202212/8278e7a7aee34e5bb378f0e0fc94e0f0.shtml.
    [11]
    [12]
    国务院应对新型冠状病毒肺炎疫情联防联控机制综合组. 关于对新型冠状病毒感染实施"乙类乙管"的总体方案[EB/OL]. [2023-01-05]. http://www.nhc.gov.cn/xcs/zhengcwj/202212/e97e4c449d7a475794624b8ea12123c6.shtml.
    [13]
    国家卫生健康委办公厅, 国家中医药局综合司. 关于印发新型冠状病毒感染诊疗方案(试行第十版)的通知[A/OL]. [2023-01-06]. http://www.gov.cn/zhengce/zhengceku/2022-03/15/content_5679257.htm.
    [14]
    WANG Q, IKETANI S, LI Z, et al. Alarming antibody evasion properties of rising SARS-CoV-2 BQ and XBB subvariants[J]. Cell, 2022, DOI: 10.1016/j.cell.2022.12.018[Epub ahead of print].
    [15]
    CALLAWAY E. Heavily mutated Omicron variant puts scientists on alert[J]. Nature, 2021, 600(7887): 21. DOI: 10.1038/d41586-021-03552-w.
    [16]
    中国疾控中心病毒病所, 中国疾病预防控制中心. 关于XBB. 1.5毒株, 这些知识您需要了解[EB/OL]. [2023-01-07]. https://www.chinacdc.cn/jkzt/crb/zl/szkb_11803/jszl_2275/202301/t20230104_263205.html.
    [17]
    陶焱炀, 王哲, 孙昼, 等. 奥密克戎变异株引起的新型冠状病毒肺炎流行病学分析[J]. 国际流行病学传染病学杂志, 2022, 49(5): 314-319. DOI: 10.3760/cma.j.cn331340-20220708-00153.

    TAO YY, WANG Z, SUN Z, et al. Analysis on the epidemic of COVID-19 caused by Omicron variant in Hangzhou[J]. Intern J Epidemiol Infect Dis, 2022, 49(5): 314-319. DOI: 10.3760/cma.j.cn331340-20220708-00153.
    [18]
    VAN DOREMALEN N, BUSHMAKER T, MORRIS DH, et al. Aerosol and surface stability of SARS-CoV-2 as compared with SARS-CoV-1[J]. N Engl J Med, 2020, 382(16): 1564-1567. DOI: 10.1056/NEJMc2004973.
    [19]
    国家卫生健康委员会办公厅, 国家中医药管理局办公室. 关于印发新型冠状病毒肺炎诊疗方案(试行第九版)的通知[A/OL]. [2023-01-06]. http://www.gov.cn/zhengce/zhengceku/2022-03/15/content_5679257.htm.
    [20]
    AL BAYAT S, MUNDODAN J, HASNAIN S, et al. Can the cycle threshold (Ct) value of RT-PCR test for SARS CoV2 predict infectivity among close contacts?[J]. J Infect Public Health, 2021, 14(9): 1201-1205. DOI: 10.1016/j.jiph.2021.08.013.
    [21]
    MISHRA B, RANJAN J, PURUSHOTHAM P, et al. High proportion of low cycle threshold value as an early indicator of COVID-19 surge[J]. J Med Virol, 2022, 94(1): 240-245. DOI: 10.1002/jmv.27307.
    [22]
    中华医学会器官移植学分会, 中国医师协会器官移植医师分会. 中国公民逝世后捐献供器官功能评估和维护专家共识(2016版)[J/CD]. 中华移植杂志(电子版), 2016, 10(4): 145-153. DOI: 10.3877/cma.j.issn.1674-3903.2016.04.001.

    Branch of Organ Transplantation of Chinese Medical Association, Chinese Society of Organ Transplantation, Branch of Organ Transplant Physician of Chinese Medical Doctor Association. Expert consensus on the assessment and maintenance of the function of donor organs donated after citizen's death in China (2016 edition)[J/CD]. Chin J Transplant (Electr Edit), 2016, 10(4): 145-153. DOI: 10.3877/cma.j.issn.1674-3903.2016.04.001.
    [23]
    SHAH M, WOO HG. Omicron: a heavily mutated SARS-CoV-2 variant exhibits stronger binding to ACE2 and potently escapes approved COVID-19 therapeutic antibodies[J]. Front Immunol, 2022, 12: 830527. DOI: 10.3389/fimmu.2021.830527.
    [24]
    BREVINI T, MAES M, WEBB GJ, et al. FXR inhibition may protect from SARS-CoV-2 infection by reducing ACE2[J]. Nature, 2022, DOI: 10.1038/s41586-022-05594-0[Epub ahead of print].
    [25]
    MEO SA, MEO AS, AL-JASSIR FF, et al. Omicron SARS-CoV-2 new variant: global prevalence and biological and clinical characteristics[J]. Eur Rev Med Pharmacol Sci, 2021, 25(24): 8012-8018. DOI: 10.26355/eurrev_202112_27652.
    [26]
    STEIN SR, RAMELLI SC, GRAZIOLI A, et al. SARS-CoV-2 infection and persistence in the human body and brain at autopsy[J]. Nature, 2022, 612(7941): 758-763. DOI: 10.1038/s41586-022-05542-y.
    [27]
    HASSANEIN M, RADHAKRISHNAN Y, SEDOR J, et al. COVID-19 and the kidney[J]. Cleve Clin J Med, 2020, 87(10): 619-631. DOI: 10.3949/ccjm.87a.20072.
    [28]
    BRAUN F, LÜTGEHETMANN M, PFEFFERLE S, et al. SARS-CoV-2 renal tropism associates with acute kidney injury[J]. Lancet, 2020, 396(10251): 597-598. DOI: 10.1016/S0140-6736(20)31759-1.
    [29]
    DIAO B, WANG C, WANG R, et al. Human kidney is a target for novel severe acute respiratory syndrome coronavirus 2 infection[J]. Nat Commun, 2021, 12(1): 2506. DOI: 10.1038/s41467-021-22781-1.
    [30]
    GOLMAI P, LARSEN CP, DEVITA MV, et al. Histopathologic and ultrastructural findings in postmortem kidney biopsy material in 12 patients with AKI and COVID-19[J]. J Am Soc Nephrol, 2020, 31(9): 1944-1947. DOI: 10.1681/ASN.2020050683.
    [31]
    SHARMA P, UPPAL NN, WANCHOO R, et al. COVID-19-associated kidney injury: a case series of kidney biopsy findings[J]. J Am Soc Nephrol, 2020, 31(9): 1948-1958. DOI: 10.1681/ASN.2020050699.
    [32]
    WANG L, LI X, CHEN H, et al. Coronavirus disease 19 infection does not result in acute kidney injury: an analysis of 116 hospitalized patients from Wuhan, China[J]. Am J Nephrol, 2020, 51(5): 343-348. DOI: 10.1159/000507471.
    [33]
    WANG W, XU Y, GAO R, et al. Detection of SARS-CoV-2 in different types of clinical specimens[J]. JAMA, 2020, 323(18): 1843-1844. DOI: 10.1001/jama.2020.3786.
    [34]
    崔浩, 梁静, 向慧玲. 新型冠状病毒肺炎相关肝损伤研究进展[J]. 临床肝胆病杂志, 2022, 38(4): 931-935. DOI: 10.3969/j.issn.1001-5256.2022.04.039.

    CUI H, LIANG J, XIANG HL. Research advances in coronavirus disease 2019-related liver injury[J]. J Clin Hepatol, 2022, 38(4): 931-935. DOI: 10.3969/j.issn.1001-5256.2022.04.039.
    [35]
    GUAN WJ, NI ZY, HU Y, et al. Clinical characteristics of coronavirus disease 2019 in China[J]. N Engl J Med, 2020, 382(18): 1708-1720. DOI: 10.1056/NEJMoa2002032.
    [36]
    RICHARDSON S, HIRSCH JS, NARASIMHAN M, et al. Presenting characteristics, comorbidities, and outcomes among 5700 patients hospitalized with COVID-19 in the New York City area[J]. JAMA, 2020, 323(20): 2052-2059. DOI: 10.1001/jama.2020.6775.
    [37]
    KATES OS, FISHER CE, RAKITA RM, et al. Emerging evidence to support not always "just saying no" to SARS-CoV-2 positive donors[J]. Am J Transplant, 2020, 20(11): 3261-3262. DOI: 10.1111/ajt.16119.
    [38]
    APASL Covid-19 Task Force, LAU G, SHARMA M. Clinical practice guidance for hepatology and liver transplant providers during the COVID-19 pandemic: APASL expert panel consensus recommendations[J]. Hepatol Int, 2020, 14(4): 415-428. DOI: 10.1007/s12072-020-10054-w.
    [39]
    WANG Y, LIU S, LIU H, et al. SARS-CoV-2 infection of the liver directly contributes to hepatic impairment in patients with COVID-19[J]. J Hepatol, 2020, 73(4): 807-816. DOI: 10.1016/j.jhep.2020.05.002.
    [40]
    BLOOM PP, MEYEROWITZ EA, REINUS Z, et al. Liver biochemistries in hospitalized patients with COVID-19[J]. Hepatology, 2021, 73(3): 890-900. DOI: 10.1002/hep.31326.
    [41]
    HENRY BM, DE OLIVEIRA MHS, BENOIT S, et al. Hematologic, biochemical and immune biomarker abnormalities associated with severe illness and mortality in coronavirus disease 2019 (COVID-19): a meta-analysis[J]. Clin Chem Lab Med, 2020, 58(7): 1021-1028. DOI: 10.1515/cclm-2020-0369.
    [42]
    LIU PP, BLET A, SMYTH D, et al. The science underlying COVID-19: implications for the cardiovascular system[J]. Circulation, 2020, 142(1): 68-78. DOI: 10.1161/CIRCULATIONAHA.120.047549.
    [43]
    LINDNER D, FITZEK A, BRÄUNINGER H, et al Association of cardiac infection with SARS-CoV-2 in confirmed COVID-19 autopsy cases[J]. JAMA Cardiol, 2020, 5(11): 1281-1285. DOI: 10.1001/jamacardio.2020.3551.
    [44]
    TIAN S, XIONG Y, LIU H, et al. Pathological study of the 2019 novel coronavirus disease (COVID-19) through postmortem core biopsies[J]. Mod Pathol, 2020, 33(6): 1007-1014. DOI: 10.1038/s41379-020-0536-x.
    [45]
    WU C, HU X, SONG J, et al. Heart injury signs are associated with higher and earlier mortality in coronavirus[EB/OL]. [2023-01-06]. https://www.medrxiv.org/content/10.1101/2020.02.26.20028589v1.
    [46]
    XU Z, SHI L, WANG Y, et al. Pathological findings of COVID-19 associated with acute respiratory distress syndrome[J]. Lancet Respir Med, 2020, 8(4): 420-422. DOI: 10.1016/S2213-2600(20)30076-X.
    [47]
    AMMIRATI E, LUPI L, PALAZZINI M, et al. Prevalence, characteristics, and outcomes of COVID-19-associated acute myocarditis[J]. Circulation, 2022, 145(15): 1123-1139. DOI: 10.1161/CIRCULATIONAHA.121.056817.
    [48]
    The Ad Hoc Disease Transmission Advisory Committee of Organ Procurement and Transplantation Network. Disease transmission advisory committee[EB/OL]. [2023-01-07]. https://optn.transplant.hrsa.gov/about/committees/disease-transmission-advisory-committee/.
    [49]
    KOVAL CE, ELTEMAMY M, POGGIO ED, et al. Comparative outcomes for over 100 deceased donor kidney transplants from SARS-CoV-2 positive donors: a single-center experience[J]. Am J Transplant, 2022, 22(12): 2903-2911. DOI: 10.1111/ajt.17203.
    [50]
    KOVAL CE, POGGIO ED, LIN YC, et al. Early success transplanting kidneys from donors with new SARS-CoV-2 RNA positivity: a report of 10 cases[J]. Am J Transplant, 2021, 21(11): 3743-3749. DOI: 10.1111/ajt.16765.
    [51]
    MOLNAR MZ, HALL IE, RAGHAVAN D, et al. Kidney transplantation from SARS-CoV-2-positive deceased donor[J]. Am J Transplant, 2022, 22(4): 1280-1282. DOI: 10.1111/ajt.16905.
    [52]
    PUODZIUKAITE L, SERPYTIS M, KUNDROTAITE A, et al. Kidney transplantation from a SARS-CoV-2-positive donor for the recipients with immunity after COVID-19[J]. Transpl Infect Dis, 2021, 23(4): e13666. DOI: 10.1111/tid.13666.
    [53]
    ROMAGNOLI R, GRUTTADAURIA S, TISONE G, et al Liver transplantation from active COVID-19 donors: a lifesaving opportunity worth grasping?[J]. Am J Transplant, 2021, 21(12): 3919-3925. DOI: 10.1111/ajt.16823.
    [54]
    JAYASEKERA CR, VIKRAM HR, RIFAT Z, et al. Solid organ transplantation from SARS-CoV-2-infected donors to uninfected recipients: a single-center experience[J]. Transplant Direct, 2022, 8(2): e1286. DOI: 10.1097/TXD.0000000000001286.
    [55]
    WALL AE, MCKENNA GJ, ONACA N, et al. Utilization of a SARS-CoV-2-positive donor for liver transplantation[J]. Proc (Bayl Univ Med Cent), 2021, 35(1): 62-63. DOI: 10.1080/08998280.2021.1985888.
    [56]
    GOSS MB, LEUNG DHB, POUCH SM, et al. A new chapter in an evolving pandemic: successful pediatric liver transplantation with SARS-CoV-2+ donors[J]. Pediatr Transplant, 2022, 26(8): e14407. DOI: 10.1111/petr.14407.
    [57]
    NGUYEN MC, LEE EJ, AVERY RK, et al. Transplant of SARS-CoV-2-infected living donor liver: case report[J]. Transplant Direct, 2021, 7(8): e721. DOI: 10.1097/TXD.0000000000001178.
    [58]
    EICHENBERGER EM, CONIGLIO AC, MILANO C, et al. Transplanting thoracic COVID-19 positive donors: an institutional protocol and report of the first 14 cases[J]. J Heart Lung Transplant, 2022, 41(10): 1376-1381. DOI: 10.1016/j.healun.2022.06.018.
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