Diagnosis and treatment of common biliary complications after orthotopic liver transplantation in adults

Hu Xinwen; Li Ting

doi:10.3969/j.issn.1674-7445.2022.05.004

Volume 13 Issue 5

Sep. 2022

Turn off MathJax

Article Contents

Article Navigation > ORGAN TRANSPLANTATION > 2022 > 13(5): 569-576

Hu Xinwen, Li Ting. Diagnosis and treatment of common biliary complications after orthotopic liver transplantation in adults[J]. ORGAN TRANSPLANTATION, 2022, 13(5): 569-576. doi: 10.3969/j.issn.1674-7445.2022.05.004

Citation:

PDF( 8287 KB)

Diagnosis and treatment of common biliary complications after orthotopic liver transplantation in adults

doi: 10.3969/j.issn.1674-7445.2022.05.004

Hu Xinwen,
Li Ting^,

Department of Liver Transplantation, Transplant Medicine Research Center, the Second Xiangya Hospital of Central South University, Changsha 430011, China

More Information

Corresponding author: Li Ting, Email: liting001@csu.edu.cn
Received Date: 2022-05-01
Available Online: 2022-09-14
Publish Date: 2022-09-15

Abstract

Abstract

Liver transplantation has become an effective treatment for end-stage liver diseases. With rapid development of surgical techniques, donor selection, organ preservation and transportation, immunosuppressants and perioperative management, the overall incidence of complications after liver transplantation has been significantly decreased, whereas the incidence of biliary complications remains relatively high. At present, biliary complications after liver transplantation are still an important cause of graft failure. Nevertheless, the pathogenesis, diagnosis and treatment of biliary complications remain controversial, which are also research hotspots in the field of organ transplantation in recent years. In this article, new breakthrough and research progress upon biliary complications after orthotopic liver transplantation in adults were reviewed, aiming to provide theoretical basis for resolving biliary complications-related clinical issues.

FullText(HTML)

References(43)

References

[1]	MOY BT, BIRK JW. A review on the management of biliary complications after orthotopic liver transplantation[J]. J Clin Transl Hepatol, 2019, 7(1): 61-71. DOI: 10.14218/JCTH.2018.00028.
[2]	MAGRO B, TACELLI M, MAZZOLA A, et al. Biliary complications after liver transplantation: current perspectives and future strategies[J]. Hepatobiliary Surg Nutr, 2021, 10(1): 76-92. DOI: 10.21037/hbsn.2019.09.01.
[3]	REYES MP, FERNÁNDEZ AGUILAR JL, DE CABO SN, et al. Influence of bile duct diameter on biliary complications after liver transplantation[J]. Transplant Proc, 2020, 52(2): 569-571. DOI: 10.1016/j.transproceed.2019.12.031.
[4]	KALDAS FM, KORAYEM IM, RUSSELL TA, et al. Assessment of anastomotic biliary complications in adult patients undergoing high-acuity liver transplant[J]. JAMA Surg, 2019, 154(5): 431-439. DOI: 10.1001/jamasurg.2018.5527.
[5]	SONG S, LU T, YANG W, et al. T-tube or no T-tube for biliary tract reconstruction in orthotopic liver transplantation: an updated systematic review and Meta-analysis[J]. Expert Rev Gastroenterol Hepatol, 2021, 15(10): 1201-1213. DOI: 10.1080/17474124.2021.1903874.
[6]	NAVEZ J, MOHKAM K, DARNIS B, et al. Biliary duct-to-duct reconstruction with a tunneled retroperitoneal T-tube during liver transplantation: a novel approach to decrease biliary leaks after T-tube removal[J]. J Gastrointest Surg, 2017, 21(4): 723-730. DOI: 10.1007/s11605-016-3313-x.
[7]	LÓPEZ-ANDÚJAR R, ORÓN EM, CARREGNATO AF, et al. T-tube or no T-tube in cadaveric orthotopic liver transplantation: the eternal dilemma: results of a prospective and randomized clinical trial[J]. Ann Surg, 2013, 258(1): 21-29. DOI: 10.1097/SLA.0b013e318286e0a0.
[8]	ZHAO JZ, QIAO LL, DU ZQ, et al. T-tube vs no T-tube for biliary tract reconstruction in adult orthotopic liver transplantation: an updated systematic review and Meta-analysis[J]. World J Gastroenterol, 2021, 27(14): 1507-1523. DOI: 10.3748/wjg.v27.i14.1507.
[9]	YOON YC, ETESAMI K, KAUR N, et al. Biliary internal stents and biliary complications in adult liver transplantation[J]. Transplant Proc, 2021, 53(1): 171-176. DOI: 10.1016/j.transproceed.2020.06.019.
[10]	GIRARD E, CHAGNON G, BROISAT A, et al. From in vitro evaluation to human postmortem pre-validation of a radiopaque and resorbable internal biliary stent for liver transplantation applications[J]. Acta Biomater, 2020, 106: 70-81. DOI: 10.1016/j.actbio.2020.01.043.
[11]	MOHANKA R, RAO P, GOLHAR A, et al. Archimedes absorbable internal biliary stent in liver transplants to prevent bile leak[J]. Transplant Proc, 2021, 53(10): 2923-2928. DOI: 10.1016/j.transproceed.2021.09.020.
[12]	ZHANG Y, SHARMA A, JOO DJ, et al. Autologous adipose tissue-derived mesenchymal stem cells introduced by biliary stents or local immersion in porcine bile duct anastomoses[J]. Liver Transpl, 2020, 26(1): 100-112. DOI: 10.1002/lt.25682.
[13]	陈焕伟, 刘颖, 廖珊, 等. 保留供肝胃十二指肠动脉对肝移植术后胆道并发症的影响[J/CD]. 中华肝脏外科手术学电子杂志, 2021, 10(6): 584-588. https://www.cnki.com.cn/Article/CJFDTOTAL-ZHZW202106011.htm CHEN HW, LIU Y, LIAO S, et al. Effect of preserving gastroduodenal artery of liver graft on biliary complications after liver transplantation[J/CD]. Chin J Hepat Surg(Electr Edit), 2021, 10(6): 584-588. https://www.cnki.com.cn/Article/CJFDTOTAL-ZHZW202106011.htm
[14]	HANN A, SETH R, MERGENTAL H, et al. Biliary strictures are associated with both early and late hepatic artery stenosis[J]. Transplant Direct, 2020, 7(1): e643. DOI: 10.1097/TXD.0000000000001092.
[15]	FUJIKI M, HASHIMOTO K, PALAIOS E, et al. Probability, management, and long-term outcomes of biliary complications after hepatic artery thrombosis in liver transplant recipients[J]. Surgery, 2017, 162(5): 1101-1111. DOI: 10.1016/j.surg.2017.07.012.
[16]	VAN RIJN R, SCHURINK IJ, DE VRIES Y, et al. Hypothermic machine perfusion in liver transplantation - a randomized trial[J]. N Engl J Med, 2021, 384(15): 1391-1401. DOI: 10.1056/NEJMoa2031532.
[17]	MARKMANN JF, ABOULJOUD MS, GHOBRIAL RM, et al. Impact of portable normothermic blood-based machine perfusion on outcomes of liver transplant: the OCS liver PROTECT randomized clinical trial[J]. JAMA Surg, 2022, 157(3): 189-198. DOI: 10.1001/jamasurg.2021.6781.
[18]	FRANCHITTO A, OVERI D, MANCINELLI R, et al. Peribiliary gland damage due to liver transplantation involves peribiliary vascular plexus and vascular endothelial growth factor[J]. Eur J Histochem, 2019, 63(2): 3022. DOI: 10.4081/ejh.2019.3022.
[19]	DE JONG IEM, MATTON APM, VAN PRAAGH JB, et al. Peribiliary glands are key in regeneration of the human biliary epithelium after severe bile duct injury[J]. Hepatology, 2019, 69(4): 1719-1734. DOI: 10.1002/hep.30365.
[20]	VAN RIJN R, VAN LEEUWEN OB, MATTON APM, et al. Hypothermic oxygenated machine perfusion reduces bile duct reperfusion injury after transplantation of donation after circulatory death livers[J]. Liver Transpl, 2018, 24(5): 655-664. DOI: 10.1002/lt.25023.
[21]	OH J, KIM JM. Immunologic strategies and outcomes in ABO-incompatible living donor liver transplantation[J]. Clin Mol Hepatol, 2020, 26(1): 1-6. DOI: 10.3350/cmh.2019.0023.
[22]	ZHANG Y, ZHANG J, YI H, et al. A novel MSC-based immune induction strategy for ABO-incompatible liver transplantation: a phase I/Ⅱ randomized, open-label, controlled trial[J]. Stem Cell Res Ther, 2021, 12(1): 244. DOI: 10.1186/s13287-021-02246-4.
[23]	HOEKSTRA H, PORTE RJ, TIAN Y, et al. Bile salt toxicity aggravates cold ischemic injury of bile ducts after liver transplantation in Mdr2^+/— mice[J]. Hepatology, 2006, 43(5): 1022-1031. DOI: 10.1002/hep.21169.
[24]	BUIS CI, GEUKEN E, VISSER DS, et al. Altered bile composition after liver transplantation is associated with the development of nonanastomotic biliary strictures[J]. J Hepatol, 2009, 50(1): 69-79. DOI: 10.1016/j.jhep.2008.07.032.
[25]	PEDERSEN MR, GREENAN G, ARORA S, et al. Ursodeoxycholic acid decreases incidence of primary biliary cholangitis and biliary complications after liver transplantation: a Meta-analysis[J]. Liver Transpl, 2021, 27(6): 866-875. DOI: 10.1002/lt.25935.
[26]	BUIS CI, VERDONK RC, VAN DER JAGT EJ, et al. Nonanastomotic biliary strictures after liver transplantation, part 1: radiological features and risk factors for early vs. late presentation[J]. Liver Transpl, 2007, 13(5): 708-718. DOI: 10.1002/lt.21166.
[27]	MOENCH C, MOENCH K, LOHSE AW, et al. Prevention of ischemic-type biliary lesions by arterial back-table pressure perfusion[J]. Liver Transpl, 2003, 9(3): 285-289. DOI: 10.1053/jlts.2003.50015.
[28]	DE JONG IEM, OVERI D, CARPINO G, et al. Persistent biliary hypoxia and lack of regeneration are key mechanisms in the pathogenesis of posttransplant nonanastomotic strictures[J]. Hepatology, 2022, 75(4): 814-830. DOI: 10.1002/hep.32166.
[29]	张英才, 陈池, 杨扬. 心脏死亡器官捐献时代肝移植后缺血型胆道病变的治疗和预防[J]. 中华消化外科杂志, 2021, 20(10): 1031-1036. DOI: 10.3760/cma.j.cn115610-20210919-00471. ZHANG YC, CHEN C, YANG Y. Treatment and prevention of ischemic-type biliary lesions after liver transplantation in the donation after cardiac death era[J]. Chin J Dig Surg, 2021, 20(10): 1031-1036. DOI: 10.3760/cma.j.cn115610-20210919-00471.
[30]	CANNELLA R, DASYAM A, MILLER FH, et al. Magnetic resonance imaging of liver transplant[J]. Magn Reson Imaging Clin N Am, 2021, 29(3): 437-450. DOI: 10.1016/j.mric.2021.05.010.
[31]	KAO D, ZEPEDA-GOMEZ S, TANDON P, et al. Managing the post-liver transplantation anastomotic biliary stricture: multiple plastic versus metal stents: a systematic review[J]. Gastrointest Endosc, 2013, 77(5): 679-691. DOI: 10.1016/j.gie.2013.01.015.
[32]	SUBHASH A, BUXBAUM JL, TABIBIAN JH. Peroral cholangioscopy: update on the state-of-the-art[J]. World J Gastrointest Endosc, 2022, 14(2): 63-76. DOI: 10.4253/wjge.v14.i2.63.
[33]	PATEL F, BICK B. Biliary obstruction after transjugular intrahepatic portosystemic shunt placement[J]. ACG Case Rep J, 2021, 8(6): e00618. DOI: 10.14309/crj.0000000000000618.
[34]	CHOKPAPONE YM, MURRAY AR, MEHTA AP, et al. Morphological characteristics of biliary strictures after liver transplantation visualized using SpyGlass? cholangioscopy[J]. Case Reports Hepatol, 2020, 2020: 8850000. DOI: 10.1155/2020/8850000.
[35]	KLAIR JS, JAYARAJ M, CHANDRASEKAR VT, et al. ERCP with overtube-assisted enteroscopy in patients with Roux-en-Y gastric bypass anatomy: a systematic review and Meta-analysis[J]. Endoscopy, 2020, 52(10): 824-832. DOI: 10.1055/a-1178-9741.
[36]	WONG M, SÁNCHEZ-LUNA SA, RUSTAGI T. Endoscopic transpapillary gallbladder stenting to prevent acute cholecystitis in patients receiving FCEMS for benign biliary stricture[J]. Endosc Int Open, 2021, 9(9): E1386-E1390. DOI: 10.1055/a-1500-8028.
[37]	WONG MY, SAXENA P, KAFFES AJ. Benign biliary strictures: a systematic review on endoscopic treatment options[J]. Diagnostics (Basel), 2020, 10(4): 221. DOI: 10.3390/diagnostics10040221.
[38]	MARTINS FP, DE PAULO GA, CONTINI MLC, et al. Metal versus plastic stents for anastomotic biliary strictures after liver transplantation: a randomized controlled trial[J]. Gastrointest Endosc, 2018, 87(1): 131. e1-131. e13. DOI: 10.1016/j.gie.2017.04.013.
[39]	COTÉ GA, SLIVKA A, TARNASKY P, et al. Effect of covered metallic stents compared with plastic stents on benign biliary stricture resolution: a randomized clinical trial[J]. JAMA, 2016, 315(12): 1250-1257. DOI: 10.1001/jama.2016.2619.
[40]	中华医学会外科学分会外科手术学学组. 关于利用磁力再通术治疗肝移植术后胆道吻合口狭窄的专家建议[J]. 器官移植, 2020, 11(1): 13-18. DOI: 10.3969/j.issn.1674-7445.2020.01.003. Operative Surgery Group of Branch of Surgery of Chinese Medical Association. Expert recommendation on magnetic recanalization for the treatment of biliary anastomosis stricture after liver transplantation[J]. Organ Transplant, 2020, 11(1): 13-18. DOI: 10.3969/j.issn.1674-7445.2020.01.003.
[41]	LI Y, SUN H, YAN X, et al. Magnetic compression anastomosis for the treatment of benign biliary strictures: a clinical study from China[J]. Surg Endosc, 2020, 34(6): 2541-2550. DOI: 10.1007/s00464-019-07063-8.
[42]	SAMPAZIOTIS F, MURARO D, TYSOE OC, et al. Cholangiocyte organoids can repair bile ducts after transplantation in the human liver[J]. Science, 2021, 371(6531): 839-846. DOI: 10.1126/science.aaz6964.
[43]	KURIAL SNT, WILLENBRING H. Emerging cell therapy for biliary diseases[J]. Science, 2021, 371(6531): 786-787. DOI: 10.1126/science.abg3179.

Relative Articles

Supplements(0)

Cited By

Proportional views

Proportional views

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

Figures(3) / Tables(1)

Get Citation

PDF

XML

Article Metrics

Article views (303) PDF downloads(107)

Diagnosis and treatment of common biliary complications after orthotopic liver transplantation in adults

doi: 10.3969/j.issn.1674-7445.2022.05.004

Abstract

References

Proportional views

Catalog

通讯作者: 陈斌, bchen63@163.com

Article Metrics

Proportional views

Related

Diagnosis and treatment of common biliary complications after orthotopic liver transplantation in adults

doi: 10.3969/j.issn.1674-7445.2022.05.004

Abstract

References

Proportional views

Catalog

通讯作者: 陈斌, bchen63@163.com

Article Metrics

Proportional views

Related

Export File

Citation

Format

Content