Research progress on kidney transplantation in HIV-positive patients

Han Fei; Huang Zhengyu

doi:10.3969/j.issn.1674-7445.2022.04.004

Volume 13 Issue 4

Jul. 2022

Turn off MathJax

Article Contents

Article Navigation > ORGAN TRANSPLANTATION > 2022 > 13(4): 434-439

Han Fei, Huang Zhengyu. Research progress on kidney transplantation in HIV-positive patients[J]. ORGAN TRANSPLANTATION, 2022, 13(4): 434-439. doi: 10.3969/j.issn.1674-7445.2022.04.004

Citation:

Han Fei, Huang Zhengyu. Research progress on kidney transplantation in HIV-positive patients[J]. ORGAN TRANSPLANTATION, 2022, 13(4): 434-439. doi: 10.3969/j.issn.1674-7445.2022.04.004

Citation:

Han Fei, Huang Zhengyu. Research progress on kidney transplantation in HIV-positive patients[J]. ORGAN TRANSPLANTATION, 2022, 13(4): 434-439. doi: 10.3969/j.issn.1674-7445.2022.04.004

PDF( 6256 KB)

Research progress on kidney transplantation in HIV-positive patients

doi: 10.3969/j.issn.1674-7445.2022.04.004

Han Fei,
Huang Zhengyu^,

Department of Kidney Transplantation, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China

More Information

Corresponding author: Huang Zhengyu, Email: hzhengy@mail.sysu.edu.cn
Received Date: 2022-01-30
Available Online: 2022-07-14
Publish Date: 2022-07-15

Abstract

Abstract

Patients infected with human immunodeficiency virus (HIV) are prone to renal insufficiency, which may progress into end-stage renal disease (ESRD). HIV infection has been previously considered as an absolute contraindication of transplantation. The lives of HIV-positive ESRD patients can only maintained through dialysis. With the development of medicine, transplantation practitioners at home and abroad attempt to perform kidney transplantation in HIV-positive patients. Whether kidney transplantation is feasible for HIV-positive patients, whether HIV-positive donor kidneys can be used for transplantation, and the efficacy of kidney transplantation for HIV-positive patients has always been hot topics in the field of transplantation. In this article, HIV-associated nephropathy, the conditions of kidney transplantation for HIV-positive patients, the efficacy of kidney transplantation for HIV-positive patients, use of HIV-positive donor kidneys, use of immune-inducing drugs and postoperative use of immunosuppressants for HIV-positive patients were illustrated, aiming to provide reference for kidney transplantation for HIV-positive patients in clinical practice, application of HIV-positive donor kidneys and postoperative management of HIV-positive patients.
- Human immunodeficiency virus(HIV),
- Acquired immune deficiency syndrome(AIDS),
- Kidney transplantation,
- End-stage renal disease,
- Combination antiretroviral therapy,
- Rejection,
- Immunosuppressant

FullText(HTML)

References(38)

References

[1]	Global HIV & AIDS statistics[EB/OL]. [2022-01-01]. https://aidsinfo.unaids.org/
[2]	YANG HY, BEYMER MR, SUEN SC. Chronic disease onset among people living with HIV and AIDS in a large private insurance claims dataset[J]. Sci Rep, 2019, 9(1): 18514. DOI: 10.1038/s41598-019-54969-3.
[3]	JOHNSON LF, ANDEREGG N, ZANIEWSKI E, et al. Global variations in mortality in adults after initiating antiretroviral treatment: an updated analysis of the International epidemiology Databases to Evaluate AIDS cohort collaboration[J]. AIDS, 2019, 33(Suppl 3): S283-S294. DOI: 10.1097/QAD.0000000000002358.
[4]	WEARNE N, HUNG R, BOHMER R, et al. Kidney disease in Africans with HIV and tuberculosis[J]. AIDS, 2019, 33(7): 1207-1213. DOI: 10.1097/QAD.0000000000002204.
[5]	KUMAR MS, SIERKA DR, DAMASK AM, et al. Safety and success of kidney transplantation and concomitant immunosuppression in HIV-positive patients[J]. Kidney Int, 2005, 67(4): 1622-1629. DOI: 10.1111/j.1523-1755.2005.00245.x.
[6]	PIERROTTI LC, LITVINOV N, COSTA SF, et al. A Brazilian university hospital position regarding transplantation criteria for HIV-positive patients according to the current literature[J]. Clinics (Sao Paulo), 2019, 74: e941. DOI: 10.6061/clinics/2019/e941.
[7]	MULLER E, BOTHA FCJ, BARDAY ZA, et al. Kidney transplantation in HIV-positive patients: current practice and management strategies[J]. Transplantation, 2021, 105(7): 1492-1501. DOI: 10.1097/TP.0000000000003485.
[8]	TARIQ A, KIM H, ABBAS H, et al. Pharmacotherapeutic options for kidney disease in HIV positive patients[J]. Expert Opin Pharmacother, 2021, 22(1): 69-82. DOI: 10.1080/14656566.2020.1817383.
[9]	YUSUF AA, MUSA BM, GALADANCI NA, et al. HIV-associated nephropathy: protocol and rationale for an exploratory genotype-phenotype study in a sub-Saharan African population[J]. PLoS One, 2021, 16(4): e0249567. DOI: 10.1371/journal.pone.0249567.
[10]	KOPP JB, WINKLER C. HIV-associated nephropathy in African Americans[J]. Kidney Int Suppl, 2003(83): S43- S49. DOI: 10.1046/j.1523-1755.63.s83.10.x.
[11]	GOYAL R, SINGHAL PC. APOL1 risk variants and the development of HIV-associated nephropathy[J]. FEBS J, 2021, 288(19): 5586-5597. DOI: 10.1111/febs.15677.
[12]	BEHAR DM, KEDEM E, ROSSET S, et al. Absence of APOL1 risk variants protects against HIV-associated nephropathy in the Ethiopian population[J]. Am J Nephrol, 2011, 34(5): 452-459. DOI: 10.1159/000332378.
[13]	DUMMER PD, LIMOU S, ROSENBERG AZ, et al. APOL1 kidney disease risk variants: an evolving landscape[J]. Semin Nephrol, 2015, 35(3): 222-236. DOI: 10.1016/j.semnephrol.2015.04.008.
[14]	SANTIPRABHOB J, CHOKEPHAIBULKIT K, KHANTEE P, et al. Adipocytokine dysregulation, abnormal glucose metabolism, and lipodystrophy in HIV-infected adolescents receiving protease inhibitors[J]. Cytokine, 2020, 136: 155145. DOI: 10.1016/j.cyto.2020.155145.
[15]	NON LR, ESCOTA GV, POWDERLY WG. HIV and its relationship to insulin resistance and lipid abnormalities[J]. Transl Res, 2017, 183: 41-56. DOI: 10.1016/j.trsl.2016.12.007.
[16]	SARMA A, DAS MK. Nose to brain delivery of antiretroviral drugs in the treatment of neuroAIDS[J]. Mol Biomed, 2020, 1(1): 15. DOI: 10.1186/s43556-020-00019-8.
[17]	PRETORIUS E. Platelets in HIV: a guardian of host defence or transient reservoir of the virus?[J]. Front Immunol, 2021, 12: 649465. DOI: 10.3389/fimmu.2021.649465.
[18]	MEHRBOD P, ANDE SR, ALIZADEH J, et al. The roles of apoptosis, autophagy and unfolded protein response in arbovirus, influenza virus, and HIV infections[J]. Virulence, 2019, 10(1): 376-413. DOI: 10.1080/21505594.2019.1605803.
[19]	SNYDER A, ALSAUSKAS ZC, LEVENTHAL JS, et al. HIV-1 viral protein R induces ERK and caspase-8-dependent apoptosis in renal tubular epithelial cells[J]. AIDS, 2010, 24(8): 1107-1119. DOI: 10.1097/QAD.0b013e328337b0ab.
[20]	ROSENSTIEL PE, GRUOSSO T, LETOURNEAU AM, et al. HIV-1 Vpr inhibits cytokinesis in human proximal tubule cells[J]. Kidney Int, 2008, 74(8): 1049-1058. DOI: 10.1038/ki.2008.303.
[21]	LI J, DAS JR, TANG P, et al. Transmembrane TNF-α facilitates HIV-1 infection of podocytes cultured from children with HIV-associated nephropathy[J]. J Am Soc Nephrol, 2017, 28(3): 862-875. DOI: 10.1681/ASN.2016050564.
[22]	TANJI N, ROSS MD, TANJI K, et al. Detection and localization of HIV-1 DNA in renal tissues by in situ polymerase chain reaction[J]. Histol Histopathol, 2006, 21(4): 393-401. DOI: 10.14670/HH-21.393.
[23]	CANAUD G, DEJUCQ-RAINSFORD N, AVETTAND-FENOËL V, et al. The kidney as a reservoir for HIV-1 after renal transplantation[J]. J Am Soc Nephrol, 2014, 25(2): 407-419. DOI: 10.1681/ASN.2013050564.
[24]	GILBERT J, MANJI A. Considerations in the management of a kidney transplant patient with HIV[J]. Cureus, 2021, 13(10): e18744. DOI: 10.7759/cureus.18744.
[25]	ALAMEDDINE M, JUE JS, ZHENG I, et al. Challenges of kidney transplantation in HIV positive recipients[J]. Transl Androl Urol, 2019, 8(2): 148-154. DOI: 10.21037/tau.2018.11.09.
[26]	MIRO JM, GROSSI PA, DURAND CM. Challenges in solid organ transplantation in people living with HIV[J]. Intensive Care Med, 2019, 45(3): 398-400. DOI: 10.1007/s00134-019-05524-1.
[27]	TRULLAS JC, COFAN F, TUSET M, et al. Renal transplantation in HIV-infected patients: 2010 update[J]. Kidney Int, 2011, 79(8): 825-842. DOI: 10.1038/ki.2010.545.
[28]	ROLAND ME, BARIN B, CARLSON L, et al. HIV-infected liver and kidney transplant recipients: 1- and 3-year outcomes[J]. Am J Transplant, 2008, 8(2): 355-365. DOI: 10.1111/j.1600-6143.2007.02061.x.
[29]	STOCK PG, BARIN B, MURPHY B, et al. Outcomes of kidney transplantation in HIV-infected recipients[J]. N Engl J Med, 2010, 363(21): 2004-2014. DOI: 10.1056/NEJMoa1001197.
[30]	CHEN P, CHEN BK, MOSOIAN A, et al. Virological synapses allow HIV-1 uptake and gene expression in renal tubular epithelial cells[J]. J Am Soc Nephrol, 2011, 22(3): 496-507. DOI: 10.1681/ASN.2010040379.
[31]	MULLER E, KAHN D, MENDELSON M. Renal transplantation between HIV-positive donors and recipients[J]. N Engl J Med, 2010, 362(24): 2336-2337. DOI: 10.1056/NEJMc0900837.
[32]	CHOW EK, MASSIE AB, MUZAALE AD, et al. Identifying appropriate recipients for CDC infectious risk donor kidneys[J]. Am J Transplant, 2013, 13(5): 1227-1234. DOI: 10.1111/ajt.12206.
[33]	KUCIRKA LM, ROS RL, SUBRAMANIAN AK, et al. Provider response to a rare but highly publicized transmission of HIV through solid organ transplantation[J]. Arch Surg, 2011, 146(1): 41-45. DOI: 10.1001/archsurg.2010.303.
[34]	ROS RL, KUCIRKA LM, GOVINDAN P, et al. Patient attitudes toward CDC high infectious risk donor kidney transplantation: inferences from focus groups[J]. Clin Transplant, 2012, 26(2): 247-253. DOI: 10.1111/j.1399-0012.2011.01469.x.
[35]	SCHWEITZER EJ, PERENCEVICH EN, PHILOSOPHE B, et al. Estimated benefits of transplantation of kidneys from donors at increased risk for HIV or hepatitis C infection[J]. Am J Transplant, 2007, 7(6): 1515-1525. DOI: 10.1111/j.1600-6143.2007.01769.x.
[36]	BOWRING MG, HOLSCHER CM, ZHOU S, et al. Turn down for what? patient outcomes associated with declining increased infectious risk kidneys[J]. Am J Transplant, 2018, 18(3): 617-624. DOI: 10.1111/ajt.14577.
[37]	LOCKE JE, JAMES NT, MANNON RB, et al. Immunosuppression regimen and the risk of acute rejection in HIV-infected kidney transplant recipients[J]. Transplantation, 2014, 97(4): 446-450. DOI: 10.1097/01.TP.0000436905.54640.8c.
[38]	EL SAKHAWI K, MELICA G, SCEMLA A, et al. Belatacept-based immunosuppressive regimen in HIV-positive kidney transplant recipients[J]. Clin Kidney J, 2020, 14(8): 1908-1914. DOI: 10.1093/ckj/sfaa231.

Relative Articles

Supplements(0)

Cited By

Proportional views

Proportional views

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

Figures(1)

Get Citation

PDF

XML

Article Metrics

Article views (308) PDF downloads(79)

Research progress on kidney transplantation in HIV-positive patients

doi: 10.3969/j.issn.1674-7445.2022.04.004

Abstract

References

Proportional views

Catalog

通讯作者: 陈斌, bchen63@163.com

Article Metrics

Proportional views

Related

Research progress on kidney transplantation in HIV-positive patients

doi: 10.3969/j.issn.1674-7445.2022.04.004

Abstract

References

Proportional views

Catalog

通讯作者: 陈斌, bchen63@163.com

Article Metrics

Proportional views

Related

Export File

Citation

Format

Content