Reflection on 10 problems of clinical xenotransplantation

Dou Kefeng; Zhang Xuan

doi:10.3969/j.issn.1674-7445.2022.04.001

Volume 13 Issue 4

Jul. 2022

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Dou Kefeng, Zhang Xuan. Reflection on 10 problems of clinical xenotransplantation[J]. ORGAN TRANSPLANTATION, 2022, 13(4): 411-416. doi: 10.3969/j.issn.1674-7445.2022.04.001

Citation:

Dou Kefeng, Zhang Xuan. Reflection on 10 problems of clinical xenotransplantation[J]. ORGAN TRANSPLANTATION, 2022, 13(4): 411-416. doi: 10.3969/j.issn.1674-7445.2022.04.001

Citation:

Dou Kefeng, Zhang Xuan. Reflection on 10 problems of clinical xenotransplantation[J]. ORGAN TRANSPLANTATION, 2022, 13(4): 411-416. doi: 10.3969/j.issn.1674-7445.2022.04.001

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Reflection on 10 problems of clinical xenotransplantation

doi: 10.3969/j.issn.1674-7445.2022.04.001

Dou Kefeng^,,
Zhang Xuan

Department of Hepatobiliary Surgery, Xijing Hospital, Air Force Medical University, Xi'an 710032, China

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Corresponding author: Dou Kefeng, Email: doukef@fmmu.edu.cn
Received Date: 2022-03-30
Available Online: 2022-07-14
Publish Date: 2022-07-15

Abstract

Abstract

The shortage of donors restricts the development of organ transplantation. Xenotransplantation might act as an effective approach to resolve this problem. With the advancement of genome editing technologies as well as research and development of novel immunosuppressant, lots of breakthroughs have been achieved in the field of xenotransplantation. Nevertheless, a majority of researches are still in the preclinical stage. Recently, the success of the world's first genetically engineered pig-to-human heart transplantation has greatly inspired researchers. However, clinical xenotransplantation still faces an array of problems, including counteracting rejection, controlling inflammation, regulating coagulation disorder, improving physiological compatibility of xenografts, paying attention to the risk of interspecific infection, optimizing immunosuppressive regimen, screening donor genome editing types, selecting suitable recipients, modifying xenotransplantation guidelines, and awareness of public recognition, etc. In this article, these 10 problems were summarized, aiming to provide reference for promoting the clinical application of xenotransplantation.
- Xenotransplantation,
- Genome editing,
- Rejection,
- Inflammation,
- Coagulation disorder,
- Physiological compatibility,
- Interspecific infection,
- Immunosuppressive regimen

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References(36)

References

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