Recent progress on the roles of DAMP and NET in organ ischemia-reperfusion injury

Zou Zhirui; Man Jiangwei; Yang Li

doi:10.3969/j.issn.1674-7445.2021.06.018

Volume 12 Issue 6

Nov. 2021

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Zou Zhirui, Man Jiangwei, Yang Li. Recent progress on the roles of DAMP and NET in organ ischemia-reperfusion injury[J]. ORGAN TRANSPLANTATION, 2021, 12(6): 761-766. doi: 10.3969/j.issn.1674-7445.2021.06.018

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Recent progress on the roles of DAMP and NET in organ ischemia-reperfusion injury

doi: 10.3969/j.issn.1674-7445.2021.06.018

Department of Urology, Lanzhou University Second Hospital, Lanzhou 730000, China

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Corresponding author: Yang Li, Email: ery_yangli@lzu.edu.cn
Received Date: 2021-07-06
Publish Date: 2021-11-15

Abstract

Abstract

Ischemia-reperfusion injury (IRI) is a common pathophysiological phenomenon, secondary to multiple pathological processes, such as organ transplantation, acute kidney injury and myocardial infarction. IRI may significantly aggravate the severity of diseases and increase the fatality of patients. Aseptic inflammation is one of the critical mechanisms of IRI. Damage-associated molecular pattern (DAMP) is a pivotal substance, which mediates aseptic inflammation. After released into extracellular space, it could effectively activate the immune system, and initiate and maintain the inflammatory responses by binding with pattern recognition receptor (PRR). Neutrophil extracellular trap (NET) is a DNA-based network structure released by neutrophils during the process of inflammatory responses, which contains histones and multiple granular proteins. Recent studies have demonstrated that DAMP and NET may aggravate IRI via aseptic inflammation. In this article, relevant studies of DAMP, NET and their relationship in IRI were reviewed, which was of great significance for understanding the pathophysiological mechanism of IRI and studying the corresponding prevention and treatment strategies.

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References

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Recent progress on the roles of DAMP and NET in organ ischemia-reperfusion injury

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