Volume 12 Issue 6
Nov.  2021
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Guo Hui. Diagnostic criteria and research progress on heart allograft pathology[J]. ORGAN TRANSPLANTATION, 2021, 12(6): 662-675. doi: 10.3969/j.issn.1674-7445.2021.06.004
Citation: Guo Hui. Diagnostic criteria and research progress on heart allograft pathology[J]. ORGAN TRANSPLANTATION, 2021, 12(6): 662-675. doi: 10.3969/j.issn.1674-7445.2021.06.004
shu

Diagnostic criteria and research progress on heart allograft pathology

doi: 10.3969/j.issn.1674-7445.2021.06.004

  • Organ Transplantation Institute, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Key Laboratory of Organ Transplantation of Ministry of Education, Key Laboratory of Organ Transplantation of National Health Commission of China, Key Laboratory of Organ Transplantation of Chinese Academy of Medical Sciences, Wuhan 430030, China

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  • Corresponding author: Guo Hui, Email: zcguo@tjh.tjmu.edu.cn
  • Received Date: 2021-10-08
  • Publish Date: 2021-11-15
    Abstract
  • With the improvement of surgical technique of heart transplantation and clinical application of potent immunosuppressant, the quantity of heart transplantation and the survival time of heart allograft have been significantly improved. However, a series of complications, such as right ventricular failure, ischemia-reperfusion injury, acute rejection, "Quilty lesion", infection and chronic rejection characterized by transplant coronary artery disease (TCAD) may still occur at different stages after heart transplantation. The application of endomyocardial biopsy (EMB) makes it possible to observe and understand the pathological features of multiple complications of heart allograft including rejection, which has become the most accurate diagnostic tool for postoperative complications. In this article, the brief history of heart allograft pathology, main postoperative complications and pathological diagnostic criteria, and cutting edge research progress on diagnostic criteria of rejection were illustrated, aiming to bring clinical benefits to more recipients undergoing heart transplantation.

     

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  • [1]
    BILLINGHAM ME, CARY NR, HAMMOND ME, et al. A working formulation for the standardization of nomenclature in the diagnosis of heart and lung rejection: Heart Rejection Study Group. The International Society for Heart Transplantation[J]. J Heart Transplant, 1990, 9(6): 587-593.
    [2]
    BERRY GJ, BURKE MM, ANDERSEN C, et al. The 2013 International Society for Heart and Lung Transplantation Working Formulation for the standardization of nomenclature in the pathologic diagnosis of antibodymediated rejection in heart transplantation[J]. J Heart Lung Transplant, 2013, 32(12): 1147-1162. DOI: 10.1016/j.healun.2013.08.011.
    [3]
    DUONG VAN HUYEN JP, FEDRIGO M, FISHBEIN GA, et al. The XVth Banff Conference on Allograft Pathology the Banff Workshop Heart Report: improving the diagnostic yield from endomyocardial biopsies and Quilty effect revisited[J]. Am J Transplant, 2020, 20(12): 3308-3318. DOI: 10.1111/ajt.16083.
    [4]
    LOUPY A, HAAS M, ROUFOSSE C, et al. The Banff 2019 Kidney Meeting Report (I): updates on and clarification of criteria for T cell- and antibody-mediated rejection[J]. Am J Transplant, 2020, 20(9): 2318-2331. DOI: 10.1111/ajt.15898.
    [5]
    黄洁, 杨跃进, 杨伟宪, 等. 心内膜心肌活检监测移植心脏排斥反应—附213例次心内膜活检结果分析[J]. 中华器官移植杂志, 2007, 28(11): 672-674. DOI: 10.3760/cma.j.issn.0254-1785.2007.11.009.

    HUANG J, YANG YJ, YANG WX, et al. Role of endomyocardial biopsy in rejection surveillance after heart transplantation: an analysis of 213 endomyocardial biopsies[J]. Chin J Organ Transplant, 2007, 28(11): 672-674. DOI: 10.3760/cma.j.issn.0254-1785.2007.11.009.
    [6]
    LI L, DUAN XJ, WANG HY, et al. Acute cellular rejection and antibody-mediated rejection in endomyocardial biopsy after heart transplantation: a retrospective study from a single medical center[J]. Int J Clin Exp Pathol, 2017, 10(4): 4772-4779.
    [7]
    STEWART S, WINTERS GL, FISHBEIN MC, et al. Revision of the 1990 working formulation for the standardization of nomenclature in the diagnosis of heart rejection[J]. J Heart Lung Transplant, 2005, 24(11): 1710- 1720. DOI: 10.1016/j.healun.2005.03.019.
    [8]
    CRESPO-LEIRO MG, VEIGA-BARREIRO A, DOMÉNECH N, et al. Humoral heart rejection (severe allograft dysfunction with no signs of cellular rejection or ischemia): incidence, management, and the value of C4d for diagnosis[J]. Am J Transplant, 2005, 5(10): 2560- 2564. DOI: 10.1111/j.1600-6143.2005.01039.x.
    [9]
    BRUNEVAL P, ANGELINI A, MILLER D, et al. The XⅢth Banff Conference on Allograft Pathology: the Banff 2015 Heart Meeting Report: improving antibodymediated rejection diagnostics: strengths, unmet needs, and future directions[J]. Am J Transplant, 2017, 17(1): 42- 53. DOI: 10.1111/ajt.14112.
    [10]
    SHETTY M, CHOWDHURY YS. Heart transplantation allograft vasculopathy[M]. Treasure Island (FL): StatPearls Publishing, 2021.
    [11]
    LOUPY A, TOQUET C, ROUVIER P, et al. Late failing heart allografts: pathology of cardiac allograft vasculopathy and association with antibody-mediated rejection[J]. Am J Transplant, 2016, 16(1): 111-120. DOI: 10.1111/ajt.13529.
    [12]
    SZYMANSKA S, GRAJKOWSKA W, SOBIESZCZANSKAMALEK M, et al. Prevalence of the Quilty effect in endomyocardial biopsy of patients after heart transplantation - from cellular rejection to antibody-mediated rejection?[J]. Pol J Pathol, 2016, 67(3): 216-220. DOI: 10.5114/pjp.2016.63772.
    [13]
    CHO H, CHOI JO, JEON ES, et al. Quilty lesions in the endomyocardial biopsies after heart transplantation[J]. J Pathol Transl Med, 2019, 53(1): 50-56. DOI: 10.4132/jptm.2018.11.30.
    [14]
    NOVÁK J, MACHÁČKOVÁ T, KREJČÍ J, et al. MicroRNAs as theranostic markers in cardiac allograft transplantation: from murine models to clinical practice[J]. Theranostics, 2021, 11(12): 6058-6073. DOI: 10.7150/thno.56327.
    [15]
    CONSTANSO-CONDE I, HERMIDA-PRIETO M, BARGE-CABALLERO E, et al. Circulating miR- 181a-5p as a new biomarker for acute cellular rejection in heart transplantation[J]. J Heart Lung Transplant, 2020, 39(10): 1100-1108. DOI: 10.1016/j.healun.2020.05.018.
    [16]
    GRANKVIST R, CHIREH A, SANDELL M, et al. Myocardial micro-biopsy procedure for molecular characterization with increased precision and reduced trauma[J]. Sci Rep, 2020, 10(1): 8029. DOI: 10.1038/s41598-020-64900-w.
    [17]
    NOVÁKOVÁ T, MACHÁČKOVÁ T, NOVÁK J, et al. Identification of a diagnostic set of endomyocardial biopsy microRNAs for acute cellular rejection diagnostics in patients after heart transplantation using nextgeneration sequencing[J]. Cells, 2019, 8(11): 1400. DOI: 10.3390/cells8111400.
    [18]
    ESCHER F, PIETSCH H, ALESHCHEVA G, et al. Evaluation of myocardial gene expression profiling for superior diagnosis of idiopathic giant-cell myocarditis and clinical feasibility in a large cohort of patients with acute cardiac decompensation[J]. J Clin Med, 2020, 9(9): 2689. DOI: 10.3390/jcm9092689.
    [19]
    LIN-WANG HT, CIPULLO R, DIAS FRANÇA JI, et al. Intragraft vasculitis and gene expression analysis: association with acute rejection and prediction of mortality in long-term heart transplantation[J]. Clin Transplant, 2018, 32(10): e13373. DOI: 10.1111/ctr.13373.
    [20]
    KHUSH KK, PATEL J, PINNEY S, et al. Noninvasive detection of graft injury after heart transplant using donor-derived cell-free DNA: a prospective multicenter study[J]. Am J Transplant, 2019, 19(10): 2889-2899. DOI: 10.1111/ajt.15339.
    [21]
    GIARRAPUTO A, BARISON I, FEDRIGO M, et al. A changing paradigm in heart transplantation: an integrative approach for invasive and non-invasive allograft rejection monitoring[J]. Biomolecules, 2021, 11(2): 201. DOI: 10.3390/biom11020201.
    [22]
    DENG MC. The evolution of patient-specific precision biomarkers to guide personalized heart-transplant care[J]. Expert Rev Precis Med Drug Dev, 2021, 6(1): 51-63. DOI: 10.1080/23808993.2021.1840273.
    [23]
    DENG MC, EISEN HJ, MEHRA MR, et al. Noninvasive discrimination of rejection in cardiac allograft recipients using gene expression profiling[J]. Am J Transplant, 2006, 6(1): 150-160. DOI: 10.1111/j.1600-6143.2005.01175.x.
    [24]
    NORTH PE, ZIEGLER E, MAHNKE DK, et al. Cellfree DNA donor fraction analysis in pediatric and adult heart transplant patients by multiplexed allelespecific quantitative PCR: validation of a rapid and highly sensitive clinical test for stratification of rejection probability[J]. PLoS One, 2020, 15(1): e0227385. DOI: 10.1371/journal.pone.0227385.
    [25]
    FITZSIMONS SJ, EVANS JDW, RASSL DM, et al. Highsensitivity cardiac troponin is not associated with acute cellular rejection after heart transplantation[J]. Transplantation, 2021, DOI: 10.1097/TP.0000000000003876[Epubaheadofprint].
    [26]
    ERBEL C, TASKIN R, DOESCH A, et al. High-sensitive Troponin T measurements early after heart transplantation predict short- and long-term survival[J]. Transpl Int, 2013, 26(3): 267-272. DOI: 10.1111/tri.12024.
    [27]
    VACCHI E, BURRELLO J, DI SILVESTRE D, et al. Immune profiling of plasma-derived extracellular vesicles identifies Parkinson disease[J]. Neurol Neuroimmunol Neuroinflamm, 2020, 7(6): e866. DOI: 10.1212/NXI.0000000000000866.
    [28]
    BURRELLO J, BOLIS S, BALBI C, et al. An extracellular vesicle epitope profile is associated with acute myocardial infarction[J]. J Cell Mol Med, 2020, 24(17): 9945-9957. DOI: 10.1111/jcmm.15594.
    [29]
    LOUPY A, AUBERT O, ORANDI BJ, et al. Prediction system for risk of allograft loss in patients receiving kidney transplants: international derivation and validation study[J]. BMJ, 2019, 366: l4923. DOI: 10.1136/bmj.l4923.
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