Volume 12 Issue 1
Jan.  2021
Turn off MathJax
Article Contents
Article Navigation >  ORGAN TRANSPLANTATION  > 2021  >  12(1): 103-108
Li Qinyuan, Jiang Wei, Feng Cheng, et al. Application value of ultrasound elastography in evaluating liver elasticity of stable recipients at different stages after liver transplantation[J]. ORGAN TRANSPLANTATION, 2021, 12(1): 103-108. doi: 10.3969/j.issn.1674-7445.2021.01.016
Citation: Li Qinyuan, Jiang Wei, Feng Cheng, et al. Application value of ultrasound elastography in evaluating liver elasticity of stable recipients at different stages after liver transplantation[J]. ORGAN TRANSPLANTATION, 2021, 12(1): 103-108. doi: 10.3969/j.issn.1674-7445.2021.01.016
shu

Application value of ultrasound elastography in evaluating liver elasticity of stable recipients at different stages after liver transplantation

doi: 10.3969/j.issn.1674-7445.2021.01.016

  • Guangdong Medical University, Zhanjiang 524000, China

More Information
  • Corresponding author: Dong Changfeng, E-mail:dongchangfeng7@163.com
  • Received Date: 2020-09-05
    Available Online: 2021-01-19
  • Publish Date: 2021-01-19
    Abstract
  •   Objective  To explore the value of ultrasound elastography in the non-invasive monitoring of liver elasticity of stable recipients at different stages after liver transplantation.  Methods  Clinical data of 73 stable recipients after liver transplantation were collected. According to the time after liver transplantation, all patients were divided into the early group (n=25) and medium-to-long group (n=48). In addition, 38 healthy subjects were assigned into the control group. The ultrasound indexes and liver function indexes were statistically compared among each group. The ultrasound elastography indexes of liver and spleen were analyzed, and their correlation with liver function indexes was analyzed.  Results  Compared with the control group, the ultrasound indexes, alanine aminotransferase (ALT), γ-glutamyl transferase (GGT) and alkaline phosphatase (ALP) levels were significantly increased in the early group (all P < 0.05), and the ultrasound indexes in the medium-to-long group were significantly increased, whereas the GGT level was significantly decreased (all P < 0.05). Compared with the early group, the right oblique diameter of liver, ALT, GGT and ALP levels were significantly decreased in the medium-to-long group (all P < 0.05). Compared with the control group, the sound touch elastography (STE) and sound touch quantify (STQ) values of liver and STE value of spleen in the early group and medium-to-long group were significantly increased (all P < 0.05). Compared with the early group, the ultrasound elastography indexes of liver and spleen in the medium-to-long group were remarkably decreased (all P < 0.05). The ultrasound elastography indexes of liver were weakly correlated with the ALT, aspartate aminotransferase (AST) and GGT levels, significantly correlated with ALP level. The STE value of spleen was weakly correlated with the ALP level. The STE value of liver was significantly correlated with the STQ value of liver. The STE and STQ values of liver were weakly correlated with the STE value of spleen.  Conclusions  The characteristics of liver elasticity in stable recipients after liver transplantation are various among different stages. Persistent monitoring of liver elasticity may provide a novelnon-invasive monitoring method during follow-up after liver transplantation.

     

    • FullText(HTML)
  • loading
    • References(25)
  • [1]
    MEIRELLES JÚNIOR RF, SALVALAGGIO P, REZENDE MB, et al. Liver transplantation: history, outcomes and perspectives[J]. Einstein (Sao Paulo), 2015, 13(1):149-152. DOI: 10.1590/S1679-45082015RW3164.
    [2]
    JEGADEESAN M, GOYAL N, RASTOGI H, et al. Percutaneous transhepatic biliary drainage for biliary stricture after endotherapy failure in living donor liver transplantation: a single-centre experience from India[J]. J Clin Exp Hepatol, 2019, 9(6):684-689. DOI: 10.1016/j.jceh.2019.03.004.
    [3]
    YUAN K, LAI C, WEI L, et al. The effect of vascular endothelial growth factor on bone marrow mesenchymal stem cell engraftment in rat fibrotic liver upon transplantation[J]. Stem Cells Int, 2019:5310202. DOI: 10.1155/2019/5310202.
    [4]
    BHAT M, TAZARI M, SEBASTIANI G. Performance of transient elastography and serum fibrosis biomarkers for non-invasive evaluation of recurrent fibrosis after liver transplantation: a Meta-analysis[J]. PLoS One, 2017, 12(9):e0185192. DOI: 10.1371/journal.pone.0185192.
    [5]
    刘懿禾, 郑虹, 沈中阳.肝移植术后中远期并发症的防治任务与策略[J].临床肝胆病杂志, 2019, 35(11):2386-2390. DOI: 10.3969/j.issn.1001-5256.2019.11.002.

    LIU YH, ZHENG H, SHEN ZY. Tasks and strategies for the prevention and treatment of middle- and long-term complications after liver transplantation[J]. J Clin Hepatol, 2019, 35(11):2386-2390. DOI: 10.3969/j.issn.1001-5256.2019.11.002.
    [6]
    BRAVO AA, SHETH SG, CHOPRA S. Liver biopsy[J]. N Engl J Med, 2001, 344(7):495-500. DOI: 10.1056/NEJM200102153440706.
    [7]
    董常峰, 冯程, 王耀, 等.超声弹性成像在肝移植术后中期的应用价值[J].中国超声医学杂志, 2019, 35(7):620-622. DOI: 10.3969/j.issn.1002-0101.2019.07.017.

    DONG CF, FENG C, WANG Y, et al. Application of ultrasonic elastography in the evaluation of patients with liver transplantation in mid-term[J]. Chin J Ultrasound Med, 2019, 35(7):620-622. DOI: 10.3969/j.issn.1002-0101.2019.07.017.
    [8]
    董常峰, 冯程, 黄婷, 等.弹性成像联合血生化指标评估慢性乙型肝炎肝纤维化程度[J].中国超声医学杂志, 2018, 34(7):623-626. DOI: 10.3969/j.issn.1002-0101.2018. 07.016.

    DONG CF, FENG C, HUANG T, et al. Elastography combined with biochemical index for assessment of hepatic fibrosis grading in chronic hepatitis B patients[J]. Chin J Ultrason Med, 2018, 34(7):623-626. DOI: 10.3969/j.issn.1002-0101.2018.07.016.
    [9]
    CAO D, WANG M, GONG J, et al. Exogenous vascular endothelial growth factor delivery prior to endothelial precursor cell transplantation in orthotopic liver transplantation-induced hepatic ischemia/reperfusion injury[J]. Liver Transpl, 2017, 23(6):804-812. DOI: 10.1002/lt.24745.
    [10]
    WONG GL, WONG VW, CHOI PC, et al. On-treatment monitoring of liver fibrosis with transient elastography in chronic hepatitis B patients[J]. Antivir Ther, 2011, 16(2):165-172. DOI: 10.3851/IMP1726.
    [11]
    朱继巧, 陈大志, 贺强, 等. DDG仪应用于肝移植患者围手术期血流动力学变化规律的探索[J].中国普通外科杂志, 2009, 18(1):16-18. https://www.cnki.com.cn/Article/CJFDTOTAL-ZPWZ200901004.htm

    ZHU JQ, CHEN DZ, HE Q, et al. Investigation on the rule of perioperative hemodynamic changes in liver transplantation patients with application of pulse dye densitograph(DDG) analyzer[J]. Chin J Gen Surg, 2009, 18(1):16-18. https://www.cnki.com.cn/Article/CJFDTOTAL-ZPWZ200901004.htm
    [12]
    孙丽莹, 王勇强, 刘懿禾, 等.肝移植术后早期血流动力学及氧代谢的变化[J].中华器官移植杂志, 2002, 23(4): 207-209. DOI: 10.3760/cma.j.issn.0254-1785.2002.04.006.

    SUN LY, WANG YQ, LIU YH, et al. Hemodynamic and oxygen metabolism changes in early stage following liver transplantation[J]. Chin J Organ Transplant, 2002, 23(4):207-209. DOI:10.3760/cma.j.issn.0254-1785. 2002.04.006.
    [13]
    MITSUHASHI Y, WAKIYA T, ISHIDO K, et al. Long-term changes in spleen volume after living donor liver transplantation in pediatric recipients[J]. Transplant Proc, 2018, 50(9):2723-2725. DOI: 10.1016/j.transproceed.2018.04.028.
    [14]
    CHEN TY, CHEN CL, HUANG TL, et al. Predictive factors for persistent splenomegaly and hypersplenism after adult living donor liver transplantation[J]. Transplant Proc, 2012, 44(3):752-754. DOI: 10.1016/j.transproceed.2012.01.044.
    [15]
    NAKAZATO PCG, VICTORINO JP, FINA CF, et al. Liver ischemia and reperfusion injury. pathophysiology and new horizons in preconditioning and therapy[J]. Acta Cir Bras, 2018, 33(8):723-735. DOI: 10.1590/s0102-865020180080000008.
    [16]
    ZHAI Y, PETROWSKY H, HONG JC, et al. Ischaemia-reperfusion injury in liver transplantation--from bench to bedside[J]. Nat Rev Gastroenterol Hepatol, 2013, 10(2):79-89. DOI: 10.1038/nrgastro.2012.225.
    [17]
    CHENG Y, JIANG Y. Liver graft perfusion methods in clinical liver transplantation[J/CD]. Chin J Hepatic Surg (Electr Edit), 2019, 8(6):477-480. DOI: 10.3877/cma.j.issn.2095-3232.2019.06.003.
    [18]
    WOO YS, LEE KH, LEE KT, et al. Postoperative changes of liver enzymes can distinguish between biliary stricture and graft rejection after living donor liver transplantation: a longitudinal study[J]. Medicine (Baltimore), 2017, 96(40):e6892. DOI: 10.1097/MD.0000000000006892.
    [19]
    廖媛, 朱高辉, 肖修平, 等.肝移植患者血清肝功能指标的动态监测及其临床意义[J].中国卫生检验杂志, 2018, 28(7):839-841. https://www.cnki.com.cn/Article/CJFDTOTAL-ZWJZ201807023.htm

    LIAO Y, ZHU GH, XIAO XP, et al. Dynamic monitoring of serum liver function indexes and its clinical significance in patients after liver transplantation[J]. Chin J Health Lab Technol, 2018, 28(7):839-841. https://www.cnki.com.cn/Article/CJFDTOTAL-ZWJZ201807023.htm
    [20]
    SUGIMOTO K, MORIYASU F, OSHIRO H, et al. Viscoelasticity measurement in rat livers using shear-wave US elastography[J]. Ultrasound Med Biol, 2018, 44(9):2018-2024. DOI: 10.1016/j.ultrasmedbio.2018.05.008.
    [21]
    ZENG J, HUANG Z, JIN J, et al. Diagnostic accuracy of 2-D shear wave elastography for the non-invasive staging of liver fibrosis in patients with elevated alanine aminotransferase levels[J]. Ultrasound Med Biol, 2018, 44(1):85-93. DOI: 10.1016/j.ultrasmedbio.2017.09.011.
    [22]
    WANG L, ZHU M, CAO L, et al. Liver stiffness measurement can reflect the active liver necroinflammation in population with chronic liver disease: a real-world evidence study[J]. J Clin Transl Hepatol, 2019, 7(4):313-321. DOI: 10.14218/JCTH.2019.00040.
    [23]
    郭欢仪, 徐士丞, 廖梅, 等.二维剪切波弹性成像肝硬度值评估慢加急性肝衰竭患者病情变化[J].中山大学学报(医学科学版), 2019, 40(5):723-730. https://www.cnki.com.cn/Article/CJFDTOTAL-ZSYK201905011.htm

    GUO HY, XU SC, LIAO M, et al. Liver stiffness for evaluating change of condition in patients with acute-on-chronic liver failure[J]. J Sun Yat-sen Univ (Med Sci), 2019, 40(5):723-730. https://www.cnki.com.cn/Article/CJFDTOTAL-ZSYK201905011.htm
    [24]
    XIA S, REN X, NI Z, et al. A noninvasive method-shear-wave elastography compared with transient elastography in evaluation of liver fibrosis in patients with chronic hepatitis B[J]. Ultrasound Q, 2019, 35(2):147-152. DOI: 10.1097/RUQ.0000000000000399.
    [25]
    郑剑, 吴曼丽, 钟梅, 等.声触诊弹性成像和声触诊弹性测量检测肝、脾硬度可行性研究[J].中华超声影像学杂志, 2019, 28(7):617-620. DOI: 10.3760/cma.j.issn. 1004-4477.2019.07.008.

    ZHENG J, WU ML, ZHONG M, et al. The applicability of sound touch elastography and sound touch quantify in measuring liver and spleen stiffness[J]. Chin J Ultrason, 2019, 28(7):617-620. DOI: 10.3760/cma.j.issn.1004-4477. 2019.07.008.
    • Relative Articles
    • Supplements(0)
    • Cited By
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Figures(1)  / Tables(4)

    Get Citation
    PDF
    XML

    Article Metrics

    Article views (353) PDF downloads(16) Cited by()
    Proportional views
    Related

    WeChat Subscription Account

    Wechat Service Account

    Contact Us
    • Tel：020-38736410
    • Email: organtranspl@163.com
    • Address：The Third Affiliated Hospital of Sun Yat-sen University, No. 600, Tianhe Road, Tianhe District, Guangzhou
    • Editorial Office of Organ Transplantation  粤ICP备2021030844号
    Links

    Supported by: Beijing Renhe Information Technology Co. Ltd    

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return