Multi-disciplinary team on renal allograft dysfunction induced by recurrence of primary hyperoxaluria type I after renal transplantation

Wang Yuchen; Yan Ziyan; Deng Wenfeng; Xia Renfei; Zeng Wenli; Luo Jia; Xu Jian; Miao Yun

doi:10.3969/j.issn.1674-7445.2021.01.012

Volume 12 Issue 1

Jan. 2021

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Wang Yuchen, Yan Ziyan, Deng Wenfeng, et al. Multi-disciplinary team on renal allograft dysfunction induced by recurrence of primary hyperoxaluria type I after renal transplantation[J]. ORGAN TRANSPLANTATION, 2021, 12(1): 77-82. doi: 10.3969/j.issn.1674-7445.2021.01.012

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Multi-disciplinary team on renal allograft dysfunction induced by recurrence of primary hyperoxaluria type I after renal transplantation

doi: 10.3969/j.issn.1674-7445.2021.01.012

Department of Organ Transplantation, Nanfang Hospital of Southern Medical University, Guangzhou 510515, China

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Corresponding author: Miao Yun, E-mail:miaoyunecho@126.com
Received Date: 2020-10-27
Available Online: 2021-01-19
Publish Date: 2021-01-19

Abstract

Abstract

Objective To investigate the clinical characteristics and the experience of multi-disciplinary team (MDT) on recurrence of primary hyperoxaluria (PH) type I after renal transplantation. Methods One case presenting with unexplained rapid decline of renal allograft function after allogeneic renal transplantation was discussed by MDT. The role of MDT in diagnosing rare hereditary diseases and improving the long-term survival of renal transplant recipients was summarized. Results After MDT consultation, the patient was diagnosed with recurrence of PH type I. Routine immunosuppressive regimen was initiated after the exclusion of rejection. The patient was instructed to drink a large quantity of water, and given with high-quality protein and low-phosphorus diet, vitamin B6, calcium and other conservative therapies to actively prevent and treat postoperative complications. The deterioration of renal graft function was delayed. Nevertheless, regular hemodialysis was resumed at 5 months after renal transplantation until the submission date of this manuscript. Conclusions Recurrence of PH type I after renal transplantation is relatively rare. The main clinical manifestations are recurrent kidney stones and decreased renal function with multiple complications and poor prognosis. The condition of the patient is consulted by MDT for confirming the diagnosis, determining the optimal treatment scheme, delaying the progression and improving the clinical prognosis.
- Renal transplantation,
- Primary hyperoxaluria (PH),
- Multi-disciplinary team (MDT),
- End stage renal disease,
- Renal allograft dysfunction,
- Alanine glyoxylate aminotransferase (AGT),
- Gene mutation,
- Genetic screening

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Multi-disciplinary team on renal allograft dysfunction induced by recurrence of primary hyperoxaluria type I after renal transplantation

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Multi-disciplinary team on renal allograft dysfunction induced by recurrence of primary hyperoxaluria type I after renal transplantation

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