Volume 11 Issue 5
Sep.  2020
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Ren Xiuyun, Gao Nong, Pan Yipeng, et al. Application value of quantitative parameters of contrast-enhanced ultrasound in evaluating donor liver from donation after brain death[J]. ORGAN TRANSPLANTATION, 2020, 11(5): 610-613. doi: 10.3969/j.issn.1674-7445.2020.05.014
Citation: Ren Xiuyun, Gao Nong, Pan Yipeng, et al. Application value of quantitative parameters of contrast-enhanced ultrasound in evaluating donor liver from donation after brain death[J]. ORGAN TRANSPLANTATION, 2020, 11(5): 610-613. doi: 10.3969/j.issn.1674-7445.2020.05.014
shu

Application value of quantitative parameters of contrast-enhanced ultrasound in evaluating donor liver from donation after brain death

doi: 10.3969/j.issn.1674-7445.2020.05.014

  • Department of Ultrasonography, the Third Medical Center of Chinese PLA General Hospital, Beijing 100039, China

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    Abstract
  •   Objective  To evaluate the application value of quantitative parameters of contrast-enhanced ultrasound (CEUS) in evaluating the donor liver from donation after brain death (DBD).   Methods  Clinical data of 25 DBD donor livers and 10 healthy adult livers were retrospectively analyzed. CEUS examinations of DBD donor livers and healthy livers were collected. Quantitative parameters included the area under curve (AUC), maximum intensity (Imax), time to peak (TTP) and mean transit time (mTT), etc.  Results  Among 25 cases of DBD donor livers, 23 cases showed normal enhancement pattern, and the other 2 cases presented with abnormal enhancement pattern. Compared with the control group, the AUC, Imax and mTT values of DBD donor livers were significantly decreased (all P < 0.05).   Conclusions  CEUS quantitative parameters can be effective means to evaluate the micro-perfusion of DBD donor livers.

     

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    • References(26)
  • [1]
    BUGGE JF. Brain death and its implications for management of the potential organ donor[J]. Acta Anaesthesiol Scand, 2009, 53(10):1239-1250. DOI: 10.1111/j.1399-6576.2009.02064.x.
    [2]
    DZIODZIO T, BIEBL M, PRATSCHKE J. Impact of brain death on ischemia/reperfusion injury in liver transplantation[J]. Curr Opin Organ Transplant, 2014, 19(2):108-114. DOI: 10.1097/MOT.0000000000000061.
    [3]
    KAHN J, SCHEMMER P. Control of ischemiareperfusion injury in liver transplantation: potentials for increasing the donor pool[J]. Visc Med, 2018, 34(6):444- 448. DOI: 10.1159/000493889.
    [4]
    CHEN S, FANG H, LI J, et al. Donor brain death leads to a worse ischemia-reperfusion injury and biliary injury after liver transplantation in rats[J]. Transplant Proc, 2020, 52(1):373-382. DOI: 10.1016/j.transproceed.2019.10.012.
    [5]
    LI H, LI J. Application of real-time contrastenhanced ultrasound in differential diagnosis of liver malignancies[J]. Can J Physiol Pharmacol, 2019, 97(5):341-344. DOI: 10.1139/cjpp-2018-0404.
    [6]
    郭源, 臧运金.公民逝世后器官捐献供肝肝移植:我国儿童肝移植的新出路[J].器官移植, 2016, 7(2): 85- 88. DOI: 10.3969/j.issn.1674-7445.2016.02.001.

    GUO Y, ZANG YJ. Liver transplantation from donation after citizen's death: the new way of pediatric liver transplantation in China[J]. Organ Transplant, 2016, 7(2): 85-88. DOI: 10.3969/j.issn.1674-7445.2016.02.001.
    [7]
    谭晓宇, 陈晓兰, 林金铭, 等.机械灌注技术引领器官捐献与移植模式的变革——器官ICU时代即将到来?[J].器官移植, 2019, 10(4):453-458.DOI:10.3969/j.issn. 1674-7445.2019.04.018.

    TAN XY, CHEN XL, LIN JM, et al. Mechine perfusion technology leads the transformation of organ donation and transplantation model: the age of organ ICU?[J]. Organ Transplant, 2019, 10(4):453-458. DOI:10.3969/ j.issn.1674-7445.2019.04.018.
    [8]
    潘宜鹏, 刘煜, 李明, 等.改良颅内加压法兔脑死亡模型建立及其状态的维持[J].中国比较医学杂志, 2016, 26(1):25-28. DOI: 10.3969.j.issn.1671.7856.2016.001.005.

    PAN YP, LIU Y, LI M, et al. Establishment of brain death model for rabbits in a modified way by increasing intracranial pressure and maintaining the state of brain death[J]. Chin J Comp Med, 2016, 26(1):25-28. DOI: 10.3969.j.issn.1671.7856.2016.001.005.
    [9]
    DESAI KK, DIKDAN GS, SHAREEF A, et al. Ischemic preconditioning of the liver: a few perspectives from the bench to bedside translation[J]. Liver Transpl, 2008, 14(11):1569-1577. DOI: 10.1002/lt.21630.
    [10]
    钟自彪, 叶啟发, 范晓礼, 等.家兔脑死亡后肝损伤机制[J/CD].中华肝脏外科手术学电子杂志, 2013, 2(5): 322- 326.DOI: 10.3877/cma.j.issn.2095-3232.2013.05.012.

    ZHONG ZB, YE QF, FAN XL, et al. Mechanism of liver injury of rabbits after brain death[J/CD]. Chin J Hepa Surg (Electr Edit), 2013, 2(5): 322-326. DOI: 10.3877/cma.j.issn.2095-3232.2013.05.012.
    [11]
    范林, 李弦, 张秋艳, 等.脑死亡供体肝脏质量影响因素[J].中华肝胆外科杂志, 2015, 21(9):637-641. DOI: 10.3760/cma.j.issn.1007-8118.2015.09.017.

    FAN L, LI X, ZHANG QY, et al. Risk factors for liver quality in donation after brain death[J]. Chin J Hepatobil Surg, 2015, 21(9):637-641. DOI: 10.3760/cma.j.issn.1007-8118.2015.09.017.
    [12]
    王力, 黄品同, 何慧疗, 等.声辐射力脉冲成像技术定量评价兔肝缺血后弹性改变的实验研究[J].中华超声影像学杂志, 2010, 19(11):989-992. DOI:10.3760/cma. j.issn.1004-4477.2010.11.024.

    WANG L, HUANG PT, HE HL, et al. Quantitative assessment of ischemic liver's elastic changes in rabbits using acoustic radiation force impulse (ARFI) [J]. Chin J Ultrason, 2010, 19(11):989-992. DOI:10.3760/cma.j.issn. 1004-4477.2010.11.024.
    [13]
    TONGBAI T, MCDERMOTT S, KIRANANTAWAT N, et al. Non-diagnostic CT-guided percutaneous needle biopsy of the lung: predictive factors and final diagnoses[J]. Korean J Radiol, 2019, 20(11):1515-1526. DOI: 10.3348/kjr.2019.0014.
    [14]
    SILVA JUNIOR RG, SCHMILLEVITCH J, NASCIMENTO MDE F, et al. Acoustic radiation force impulse elastography and serum fibrosis markers in chronic hepatitis C[J]. Scand J Gastroenterol, 2014, 49(8):986-992. DOI: 10.3109/00365521.2014.909528.
    [15]
    AHN JH, JANG JG. Initial experience in CT-guided percutaneous transthoracic needle biopsy of lung lesions performed by a pulmonologist[J]. J Clin Med, 2019, 8(6):821. DOI: 10.3390/jcm8060821.
    [16]
    LAURSEN CB, GRAUMANN O, MØLLER TV, et al. Contrast-enhanced ultrasound-guided transthoracic lung biopsy[J]. Am J Respir Crit Care Med, 2016, 194(5):e5- e6. DOI: 10.1164/rccm.201603-0500IM.
    [17]
    KUMAR L. Brain death and care of the organ donor[J]. J Anaesthesiol Clin Pharmacol, 2016, 32(2):146-152. DOI: 10.4103/0970-9185.168266.
    [18]
    FERRAIOLI G, WONG VW, CASTERA L, et al. Liver ultrasound elastography: an update to the world federation for ultrasound in medicine and biology guidelines and recommendations[J]. Ultrasound Med Biol, 2018, 44(12):2419-2440. DOI:10.1016/ j.ultrasmedbio.2018.07.008.
    [19]
    YAMAMOTO N, WATANABE T, YAMADA K, et al. Efficacy and safety of ultrasound (US) guided percutaneous needle biopsy for peripheral lung or pleural lesion: comparison with computed tomography (CT) guided needle biopsy[J]. J Thorac Dis, 2019, 11(3):936- 943. DOI: 10.21037/jtd.2019.01.88.
    [20]
    BRUZZONE P, BALLA A, QUARESIMA S, et al. Comparison of two questionnaires on informed consent in "marginal" donor liver[J]. Transplant Proc, 2016, 48(2):359-361. DOI: 10.1016/j.transproceed.2015.12.053.
    [21]
    REN X, LUO Y, GAO N, et al. Common ultrasound and contrast-enhanced ultrasonography in the diagnosis of hepatic artery pseudoaneurysm after liver transplantation[J]. Exp Ther Med, 2016, 12(2):1029- 1033. DOI: 10.3892/etm.2016.3343.
    [22]
    SPARCHEZ Z, MOCAN T, HAGIU C, et al. Realtime contrast-enhanced-guided biopsy compared with conventional ultrasound-guided biopsy in the diagnosis of hepatic tumors on a background of advanced chronic liver disease: a prospective, randomized, clinical trial[J]. Ultrasound Med Biol, 2019, 45(11):2915-2924. DOI: 10.1016/j.ultrasmedbio.2019.07.678.
    [23]
    LU Q, ZHANG XL, HAN H, et al. Value of perfusion parameters for differentiating hepatocellular carcinoma and liver metastasis with hypervascularity and a normal hepatic background on contrast-enhanced ultrasound imaging[J]. J Ultrasound Med, 2019, 38(10):2601-2608. DOI: 10.1002/jum.14957.
    [24]
    LI Y, LI T, QI H, et al. Minocycline protects against hepatic ischemia/reperfusion injury in a rat model[J]. Biomed Rep, 2015, 3(1):19-24. DOI: 10.3892/br.2014.381.
    [25]
    ZUGHAIER SM, TZENG YL, ZIMMER SM, et al. Neisseria meningitidis lipooligosaccharide structuredependent activation of the macrophage CD14/Toll-like receptor 4 pathway[J]. Infect Immun, 2004, 72(1):371- 380. DOI: 10.1128/iai.72.1.371-380.2004.
    [26]
    YANG HK, BURNS PN, JANG HJ, et al. Contrastenhanced ultrasound approach to the diagnosis of focal liver lesions: the importance of washout[J]. Ultrasonography, 2019, 38(4):289-301. DOI:10.14366/ usg.19006.
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