The function of regulatory immunological cell in xenotransplantation immunity

Shi Bingyi; Chen Wen; Liu Zhijia

doi:10.3969/j.issn.1674-7445.2020.03.001

Volume 11 Issue 3

May 2020

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Shi Bingyi, Chen Wen, Liu Zhijia. The function of regulatory immunological cell in xenotransplantation immunity[J]. ORGAN TRANSPLANTATION, 2020, 11(3): 321-325. doi: 10.3969/j.issn.1674-7445.2020.03.001

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The function of regulatory immunological cell in xenotransplantation immunity

doi: 10.3969/j.issn.1674-7445.2020.03.001

Organ Transplantation Institute of the 8th Medical Center of Chinese People s Liberation Army General Hospital, Beijing 100091, China

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Corresponding author: Shi Bingyi,Email:shibingyi666@126.com
Received Date: 2020-02-18
Available Online: 2021-01-19
Publish Date: 2020-05-15

Abstract

Abstract

Xenotransplantation is the most promising method to resolve the organ shortage problem in the future. In recent years, the advances in gene editing and immunological technique have driven the rapid development of xenotransplantation. However, there are still many insurmountable obstacles in the clinical application of xenotransplantation, among which the rejection is the most important cause of the xenotransplantation failure. Regulatory immunological cells are a group of immunological cells with the negative regulation function in the body, which can inhibit allotransplantation rejection and prolong the survival time of the graft. This paper summarized the research progress of regulatory immunological cells in the xenotransplantation application in recent years, providing reference for the prevention and treatment of xenotransplantation rejection.
- Regulatory immunological cell,
- Xenotransplantation,
- Rejection,
- Transplantation immunity,
- Regulatory T cell (Treg),
- Regulatory dendritic cell (DCreg),
- Follicular regulatory T cell (Tfr),
- Regulatory B cell (Breg)

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References(27)

References

[1]	STOLF NAG. Xenotransplantation: on the way to clinical application?[J]. Braz J Cardiovasc Surg, 2019,34(3):2. DOI: 10.21470/1678-9741-2019-0604.
[2]	KRAJEWSKA M, KOŚCIELSKA-KASPRZAK K, KAMIŃSKA D, et al. Kidney transplant outcome is associated with regulatory T cell population and gene expression early after transplantation[J]. J Immunol Res, 2019:7452019. DOI: 10.1155/2019/7452019.
[3]	REEMTSMA K, MCCRACKEN BH, SCHLEGEL JU, et al. Heterotransplantation of the kidney: two clinical experiences[J]. Science, 1964, 143(3607):700-702. doi: 10.1126/science.143.3607.700
[4]	STARZL TE, MARCHIORO TL, PETERS GN, et al. Renal heterotransplantation from baboon to man: experience with 6 cases[J]. Transplantation, 1964, 2:752-776. doi: 10.1097/00007890-196411000-00009
[5]	STARZL TE, VALDIVIA LA, MURASE N, et al. The biological basis of and strategies for clinical xenotransplantation[J]. Immunol Rev, 1994, 141:213-244. doi: 10.1111/j.1600-065X.1994.tb00879.x
[6]	MAKOWA L, CRAMER DV, HOFFMAN A, et al. The use of a pig liver xenograft for temporary support of a patient with fulminant hepatic failure[J]. Transplantation, 1995, 59(12):1654-1659. doi: 10.1097/00007890-199506270-00002
[7]	MCGREGOR CG, TEOTIA SS, BYRNE GW, et al. Cardiac xenotransplantation: progress toward the clinic[J]. Transplantation, 2004, 78(11):1569-1575. doi: 10.1097/01.TP.0000147302.64947.43
[8]	MOHIUDDIN MM, SINGH AK, CORCORAN PC, et al. Chimeric 2C10R4 anti-CD40 antibody therapy is critical for long-term survival of GTKO.hCD46.hTBM pig-to-primate cardiac xenograft[J]. Nat Commun, 2016, 7:11138. DOI: 10.1038/ncomms11138.
[9]	石炳毅 , 陈文 . 临床异种器官移植所面临的种种挑战 [J]. 中华器官移植杂志 ,2017,38(12):705-707. doi: 10.3760/cma.j.issn.0254-1785.2017.12.001 SHI BY, CHEN W. Challenges of clinical xenotransplantation[J]. Chin J Organ Transplant, 2017,38(12):705-707. doi: 10.3760/cma.j.issn.0254-1785.2017.12.001
[10]	石炳毅 . 调节性免疫细胞网络在移植免疫中的作用 [J]. 中华医学杂志 ,2011,91(44):3154-3157.DOI: 10. 3760/cma.j.issn.0376-2491.2011.44.018. SHI BY. Role of regulatory immune cell networks in transplantation immunity [J]. Natl Med J China, 2011,91(44):3154-3157. DOI: 10.3760/cma.j.issn. 0376- 2491.2011.44.018.
[11]	TANG Q, VINCENTI F. Transplant trials with Tregs: perils and promises[J]. J Clin Invest, 2017, 127(7):2505- 2512. DOI: 10.1172/JCI90598.
[12]	CHEN W, BAI J, HUANG H, et al. Low proportion of follicular regulatory T cell in renal transplant patients with chronic antibody-mediated rejection[J]. Sci Rep,2017, 7(1):1322. DOI: 10.1038/s41598-017-01625-3.
[13]	LINO AC, DANG VD, LAMPROPOULOU V, et al. LAG-3 inhibitory receptor expression identifies immunosuppressive natural regulatory plasma cells[J]. Immunity, 2018, 49(1):120-133. DOI: 10.1016/j.immuni.2018.06.007.
[14]	FERREIRA LMR, MULLER YD, BLUESTONE JA, et al. Next-generation regulatory T cell therapy[J]. Nat Rev Drug Discov, 2019, 18(10):749-769. DOI: 10.1038/s41573-019-0041-4.
[15]	SAITO T, NISHIKAWA H, WADA H, et al. Two Foxp3⁺CD4⁺ T cell subpopulations distinctly control the prognosis of colorectal cancers[J]. Nat Med, 2016, 22(6):679-684. DOI: 10.1038/nm.4086.
[16]	YANG S, SHENG X, XIANG D, et al. CD150^highTreg cells may attenuate graft versus host disease and intestinal cell apoptosis after hematopoietic stem cell transplantation[J]. Am J Transl Res, 2019, 11(3):1299-1310.
[17]	WU J, HU M, QIAN YW, et al. In vivo costimulation blockade-induced regulatory T cells demonstrate dominant and specific tolerance to porcine islet xenografts[J]. Transplantation, 2017, 101(7):1587-1599. DOI: 10.1097/TP.0000000000001482.
[18]	YI S, JI M, WU J, et al. Adoptive transfer with in vitro expanded human regulatory T cells protects against porcine islet xenograft rejection via interleukin-10 in humanized mice[J]. Diabetes, 2012, 61(5):1180-1191. DOI: 10.2337/db11-1306.
[19]	MA Y, HE KM, GARCIA B, et al. Adoptive transfer of double negative T regulatory cells induces B-cell death in vivo and alters rejection pattern of rat-to-mouse heart transplantation[J]. Xenotransplantation, 2008, 15(1):56- 63. DOI: 10.1111/j.1399-3089.2008.00444.x.
[20]	SHIN JS, MIN BH, KIM JM, et al. Failure of transplantation tolerance induction by autologous regulatory T cells in the pig-to-non-human primate islet xenotransplantation model[J]. Xenotransplantation, 2016, 23(4):300-309. DOI: 10.1111/xen.12246.
[21]	GORDY JT, LUO K, FRANCICA B, et al. Anti-IL- 10-mediated enhancement of antitumor efficacy of a dendritic cell-targeting MIP3α-gp100 vaccine in the B16F10 mouse melanoma model is dependent on type I interferons[J]. J Immunother, 2018, 41(4):181-189. DOI: 10.1097/CJI.0000000000000212.
[22]	THOMSON AW, TURNQUIST HR, ZAHORCHAK AF, et al. Tolerogenic dendritic cell-regulatory T-cell interaction and the promotion of transplant tolerance[J]. Transplantation, 2009, 87(9 Suppl): S86-S90. DOI: 10.1097/TP.0b013e3181a2dcec.
[23]	EZZELARAB MB, RAICH-REGUE D, LU L, et al. Renal allograft survival in nonhuman primates infused with donor antigen-pulsed autologous regulatory dendritic cells[J]. Am J Transplant, 2017, 17(6):1476-1489. DOI: 10.1111/ajt.14182.
[24]	THOMSON AW, HUMAR A, LAKKIS FG, et al. Regulatory dendritic cells for promotion of liver transplant operational tolerance: rationale for a clinical trial and accompanying mechanistic studies[J]. Hum Immunol, 2018, 79(5):314-321. DOI: 10.1016/j.humimm.2017.10.017.
[25]	TIAN M, LV Y, ZHAI C, et al. Alternative immunomodulatory strategies for xenotransplantation: CD80/CD86-CTLA4 pathway-modified immature dendritic cells promote xenograft survival[J]. PLoS One, 2013, 8(7): e69640. DOI: 10.1371/journal.pone.0069640.
[26]	MADELON N, PUGA YUNG GL, SEEBACH JD. Human anti-pig NK cell and CD8⁺ T-cell responses in the presence of regulatory dendritic cells[J]. Xenotransplantation, 2016, 23(6):479-489. DOI: 10.1111/xen.12279.
[27]	LI M, ECKL J, ABICHT JM, et al. Induction of porcinespecific regulatory T cells with high specificity and expression of IL-10 and TGF-β₁ using baboon-derived tolerogenic dendritic cells[J]. Xenotransplantation, 2018, 25(1). DOI: 10.1111/xen.12355.

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The function of regulatory immunological cell in xenotransplantation immunity

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