Volume 11 Issue 2
Mar.  2020
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Article Navigation >  ORGAN TRANSPLANTATION  > 2020  >  11(2): 271-275
Xie Yunliang, Yang Zhou, Yang Qing, et al. Analysis of clinical effects of elderly donor liver from organ donation after citizen's death in liver transplantation: a single-center experience[J]. ORGAN TRANSPLANTATION, 2020, 11(2): 271-275. doi: 10.3969/j.issn.1674-7445.2020.02.014
Citation: Xie Yunliang, Yang Zhou, Yang Qing, et al. Analysis of clinical effects of elderly donor liver from organ donation after citizen's death in liver transplantation: a single-center experience[J]. ORGAN TRANSPLANTATION, 2020, 11(2): 271-275. doi: 10.3969/j.issn.1674-7445.2020.02.014
shu

Analysis of clinical effects of elderly donor liver from organ donation after citizen's death in liver transplantation: a single-center experience

doi: 10.3969/j.issn.1674-7445.2020.02.014

  • Department of Hepatic Surgery, Liver Transplantation Center, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China

More Information
  • Corresponding author: Fu Binsheng, Email: fubinsh@mail.sysu.edu.cn
  • Received Date: 2019-12-06
    Available Online: 2021-01-19
  • Publish Date: 2020-03-15
    Abstract
  •   Objective  To explore the clinical efficacy of marginal liver from elderly donors in liver transplantation.  Methods  According to the inclusion and exclusion criteria, the clinical data of 127 donors and recipients were retrospectively analyzed. According to the age of donors, 127 donors were divided into the elderly group (n=27) and control group (n=100). The recovery of liver function, the occurrence of postoperative complications and survival rate of the recipients after transplantation were statistically analyzed between two groups.  Results  The incidence of primary nonfunction (PNF) and initial poor graft function (IPGF) did not significantly differ between the elderly and control groups (both P > 0.05). Within postoperative 2 weeks, the average levels of alanine aminotransferase (ALT) and serum total bilirubin (TB) of liver transplant recipients in the elderly group was not significantly different from those in the control group (both P > 0.05). There was no significant difference in the incidence of postoperative complications in the postoperative elderly group compared with the control group (all P > 0.05). The 1-and 3-year survival rates of the recipients in the elderly group were 84% and 78% respectively, which did not significantly differ from 89% and 79% in the control group (both P > 0.05).  Conclusions  Strict and sufficient quality evaluation and functional maintenance should be done for elderly donor livers. It can achieve good transplantation results by intraoperative fine operation, reducing bleeding and trauma, shortening the time of cold ischemia and operation, strengthening postoperative monitoring and implementing enhanced recovery after surgery.

     

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