Volume 11 Issue 2
Mar.  2020
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Article Navigation >  ORGAN TRANSPLANTATION  > 2020  >  11(2): 265-270
Jiang Xiaoqing, Zhang Qun, Xie Man, et al. Literature analysis report of de novo malignant tumors of digestive system after liver transplantation in China[J]. ORGAN TRANSPLANTATION, 2020, 11(2): 265-270. doi: 10.3969/j.issn.1674-7445.2020.02.013
Citation: Jiang Xiaoqing, Zhang Qun, Xie Man, et al. Literature analysis report of de novo malignant tumors of digestive system after liver transplantation in China[J]. ORGAN TRANSPLANTATION, 2020, 11(2): 265-270. doi: 10.3969/j.issn.1674-7445.2020.02.013
shu

Literature analysis report of de novo malignant tumors of digestive system after liver transplantation in China

doi: 10.3969/j.issn.1674-7445.2020.02.013

  • Department of Gastroenterology, the Affiliated Hospital of Qingdao University, Qingdao 266000, China

More Information
  • Corresponding author: Rao Wei, Email: qdfy_raowei@126.com
  • Received Date: 2019-12-03
    Available Online: 2021-01-19
  • Publish Date: 2020-03-15
    Abstract
  •   Objective  To investigate the incidence of de novo malignant tumors of the digestive system after liver transplantation (LT) in China.  Methods  Relevant literature review was performed from Wanfang data, China National Knowledge Infrastructure (CNKI) and Chongqing VIP. The retrieval time started from the establishment of each database to May 9, 2019. The Chinese search terms were liver transplantation+ postoperative/de novo+ malignant tumor/cancer. The age distribution, sex composition, time of diagnosis, involved organs, treatment and clinical prognosis of recipients with de novo malignant tumors of the digestive system after LT in China were retrospectively analyzed.  Results  After literature screening, 16 articles were eventually selected including 47 cases of de novo malignant tumors of the digestive system after LT. A majority of them were male recipients. The age of the recipients was 51 (23-65) years old, most of them were middle age (45-59 years old). The average time of diagnosis of de novo malignant tumors of the digestive system after operation was 43 (2-156) months, with the highest number of cases within postoperative 1-3 years. Colon and stomach were the most common tumor sites. Surgery combined with radiotherapy and chemotherapy remained the main treatment option. However, the overall clinical prognosis of patients with de novo malignant tumors of the digestive system after LT was poor with a mortality rate of 51%.  Conclusions  In China, colon cancer and gastric cancer are the main de novo malignant tumors of the digestive system after LT. The overall clinical prognosis of patients with de novo malignant tumors of the digestive system is poor. Sufficient attention should be paid to postoperative monitoring and prevention.

     

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    • References(32)
  • [1]
    王少发, 陈孝平.中国肝移植发展概况[J].中华器官移植杂志, 2018, 39(5):307-310. DOI:10.3760/cma.j.issn. 0254-1785.2018.05.011.

    WANG SF, CHEN XP. Overview of liver transplantation in China[J]. Chin J Organ Transplant, 2018, 39(5):307-310. DOI: 10.3760/cma.j.issn.0254-1785.2018.05.011.
    [2]
    程道柔, 杨卿, 张英才, 等.肝移植术中脾肾分流的个体化处理[J].器官移植, 2019, 10(4):443-448.DOI:10. 3969/j.issn.1674-7445.2019.04.016.

    CHENG DR, YANG Q, ZHANG YC, et al. Individualized treatment of splenorenal shunt during liver transplantation[J]. Organ Transplant, 2019, 10(4):443-448.DOI: 10.3969/j.issn.1674-7445.2019.04.016.
    [3]
    BHAT M, MARA K, DIERKHISING R, et al. Gender, race and disease etiology predict de novo malignancy risk after liver transplantation: insights for future individualized cancer screening guidance[J]. Transplantation, 2019, 103(1):91-100. DOI: 10.1097/TP.0000000000002113.
    [4]
    张志军, 张微, 钟海钢, 等.肝移植后新发消化系统恶性肿瘤研究现状及防治进展[J].中华器官移植杂志, 2016, 37(7):439-441.DOI:10.3760/cma.j.issn.0254- 1785.2016.07.012.

    ZHANG ZJ, ZHANG W, ZHONG HG, et al. Research status and prevention progress of new digestive system malignant tumors after liver transplantation[J]. Chin J Organ Transplant, 2016, 37(7):439-441. DOI: 10.3760/cma.j.issn.0254-1785.2016.07.012.
    [5]
    饶伟, 解曼, 刘东岳, 等.中国肝移植术后新发恶性肿瘤文献分析报告[J/CD].中华移植杂志(电子版), 2018, 12(4): 165-169.DOI: 10.3877/cma.j.issn.1674-3903.2018.04.005.

    RAO W, XIE M, LIU DY, et al. Analysis of de novo malignancies after liver transplantation in China: based on literature published[J/CD]. Chin J Transplant (Electr Vers), 2018, 12(4): 165-169. DOI: 10.3877/cma.j.issn.1674-3903.2018.04.005.
    [6]
    周学平, 张海斌, 韩龙志, 等.肝癌肝移植术后合并胃癌1例报告[J].中国实用外科杂志, 2005, 25(5):289. DOI: 10.3321/j.issn:1005-2208.2005.05.027.

    ZHOU XP, ZHANG HB, HAN LZ, et al. A case report of gastric cancer after liver transplantation for hepatocellular carcinoma[J]. Chin J Pract Surg, 2005, 25(5):289. DOI: 10.3321/j.issn:1005-2208.2005.05.027.
    [7]
    袁伟升, 刘鹏, 王志远, 等.肝癌肝移植术后合并胃癌一例[J].中华胃肠外科杂志, 2006, 9(5):428. DOI: 10.3760/cma.j.issn.1671-0274.2006.05.037.

    YUAN WS, LIU P, WANG ZY, et al. A case of gastric cancer after liver transplantation for hepatocellular carcinoma[J]. Chin J Gastrointest Surg, 2006, 9(5):428. DOI: 10.3760/cma.j.issn.1671-0274.2006.05.037.
    [8]
    白雪, 李世拥.肝移植术后直肠癌患者行根治性切除保肛术一例报告[J/CD].中华普外科手术学杂志(电子版), 2007, 1(1): 78-79.DOI: 10.3969/j.issn.1674-3946.2007.01.024.

    BAI X, LI SY. A case report of rectal cancer patients undergoing radical resection and anal preservation after liver transplantation[J/CD]. Chin J Oper Proce Gene Surg (Electr Vers), 2007, 1(1): 78-79. DOI: 10.3969/j.issn.1674-3946.2007.01.024.
    [9]
    吕毅, 胡良硕, 刘昌, 等.再次肝移植术后继发喉部神经内分泌癌1例[J].现代肿瘤医学, 2008, 16(7):1210-1211. DOI: 10.3969/j.issn.1672-4992.2008.07.061.

    LYU Y, HU LS, LIU C, et al. Suffering from secondary laryngeal neuroendocrine carcinoma after second liverretransplantation, one case report[J]. J Mod Oncol, 2008, 16(7):1210-1211.DOI:10.3969/j.issn.1672-4992. 2008.07.061.
    [10]
    李风, 周光文, 中川, 等.肝移植术后并发结肠癌一例[J].中华外科杂志, 2008, 46(11):878.DOI: 10.3321/j.issn:0529-5815.2008.11.029.

    LI F, ZHOU GW, ZHONG C, et al. A case of colon cancer after liver transplantation[J]. Chin J Surg, 2008, 46(11):878. DOI: 10.3321/j.issn:0529-5815.2008.11.029.
    [11]
    曲兴龙, 柴宇啸, 王奕静, 等.肝癌肝移植术后合并胃癌1例报告[J].中国实用外科杂志, 2011, 31(6):548-548. http://d.old.wanfangdata.com.cn/Periodical/zgsywkzz200505027

    QU XL, CHAI YX, WANG YJ, et al. Gastric cancer after liver transplantation of liver cancer: a case report[J]. Chin J Pract Surg, 2011, 31(6):548-548. http://d.old.wanfangdata.com.cn/Periodical/zgsywkzz200505027
    [12]
    张彤, 傅斌生, 李华, 等.肝移植术后新发胃癌1例临床分析附文献复习[J].器官移植, 2011, 2(2):82-85, 98. DOI: 10.3969/j.issn.1674-7445.2011.02.006.

    ZHANG T, FU BS, LI H, et al. De novo gastric cancer after liver transplantation: a case report and literature review[J].Organ Transplant, 2011, 2(2):82-85, 98. DOI:10. 3969/j.issn.1674-7445.2011.02.006.
    [13]
    章笑忠, 王文涛, 杨俭, 等.重视肝移植术后新发肿瘤的发生与防治一附单中心5例报告[J].实用医院临床杂志, 2011, 8(6):46-51.DOI:10.3969/j.issn.1672-6170. 2011.06.014.

    ZHANG XZ, WANG WT, YANG J, et al. Attach great importance to the occurance and prevention of the de novo malignancy after liver transplantation with 5 cases in a single center[J]. Pract J Clin Med, 2011, 8(6):46-51. DOI: 10.3969/j.issn.1672-6170.2011.06.014.
    [14]
    张磊, 邹游, 滕飞, 等.肝移植术后结直肠恶性肿瘤的诊疗(附6例报告)[J].第二军医大学学报, 2012, 33(10): 1107-1111.DOI: 10.3724/SP.J.1008.2012.01107.

    ZHANG L, ZOU Y, TENG F, et al. Diagnosis and treatment of colorectal cancer after liver transplantation: a report of 6 cases[J]. Acade J Sec Mil Med Univ, 2012, 33(10):1107-1111. DOI: 10.3724/SP.J.1008.2012.01107.
    [15]
    李新宇, 栗光明, 黄磊, 等.肝移植患者术后新发恶性肿瘤临床分析[J/CD].中华肝脏外科手术学电子杂志, 2013, 2(6): 371-374.DOI: 10.3877/cma.j.issn.2095-3232. 2013.06.006.

    LI XY, LI GM, HUANG L, et al. Clinical analysis of de novo neoplasms in patients after liver transplantation[J/CD]. Chin J Hepa Surg(Electr Edit), 2013, 2(6): 371-374. DOI: 10.3877/cma.j.issn.2095-3232.2013.06.006.
    [16]
    易述红, 易慧敏, 傅斌生, 等.肝移植术后新发恶性肿瘤的发生和防治(附九例报告)[J/CD].中华肝脏外科手术学电子杂志, 2014, 3(3): 148-151. DOI: 10.3877/cma.j.issn.2095-3232.2014.03.005.

    YI SH, YI HM, FU BS, et al. De novo malignancies following liver transplantation: report of 9 cases[J/CD]. Chin J Hepa Surg(Electr Edit), 2014, 3(3): 148-151. DOI: 10.3877/cma.j.issn.2095-3232.2014.03.005.
    [17]
    邓侃, 潘晓云, 徐洁, 等.一例肝移植术后并发糖尿病患者行食道癌手术的护理[J].护士进修杂志, 2015, 30(23): 2206-2207. http://d.old.wanfangdata.com.cn/Periodical/hsjxzz201523037

    DENG K, PAN XY, XU J, et al. Nursing care of a patient with diabetes mellitus after liver transplantation undergoing esophageal cancer surgery[J]. J Nurses Train, 2015, 30(23):2206-2207. http://d.old.wanfangdata.com.cn/Periodical/hsjxzz201523037
    [18]
    王振, 李世朋, 张建军.肝移植术后新发消化系统恶性肿瘤8例临床分析[J/CD].实用器官移植电子杂志, 2016, 4(1): 37-39.DOI: 10.3969/j.issn.2095-5332.2016.01.007.

    WANG Z, LI SP, ZHAN JJ. De novo digestive system malignancy after liver transplantation: a single-center clinical analysis of cases[J/CD]. Pract J Organ Transplant (Electr Vers), 2016, 4(1): 37-39. DOI: 10.3969/j.issn.2095-5332.2016.01.007.
    [19]
    张志军, 钟海钢, 张微, 等.肝移植术后新发消化系统恶性肿瘤的诊治十例[J].中华器官移植杂志, 2016, 37(9): 513-517.DOI:10.3760/cma.j.issn.0254-1785.2016.09.001.

    ZHANG ZJ, ZHONG HG, ZHANG W, et al. De novo digestive system malignancy after liver transplantation[J]. Chin J Organ Transplant, 2016, 37(9):513-517. DOI: 10.3760/cma.j.issn.0254-1785.2016.09.001.cma.j.issn.0254-1785.2016.09.001.
    [20]
    梁娟娟, 范铁艳, 陈虹.肝移植术后新发舌根癌1例临床分析并文献复习[J].中国急救复苏与灾害医学杂志, 2017, 12(6):597-598.DOI:10.3969/j.issn.1673-6966. 2017.06.032.

    LIANG JJ, FAN TY, CHEN H, et al. New tongue root carcinoma after liver transplantation: a case clinical analysis and literature review[J]. Chin J Emerg Resus Disast Med, 2017, 12(6):597-598. DOI: 10.3969/j.issn.1673-6966.2017.06.032.
    [21]
    王旭, 陈虹, 范铁艳, 等.肝移植术后新发恶性肿瘤的临床分析[J].中国肿瘤, 2017, 26(5):410-414. DOI: 10.11735/j.issn.1004-0242.2017.05.A017.

    WANG X, CHEN H, FAN TY, et al. Clinical analysis on de novo malignancies after liver transplantation[J]. Chin Cancer, 2017, 26(5):410-414.DOI:10.11735/j.issn.1004- 0242.2017.05.A017.
    [22]
    The Joanna Briggs Institute.Joanna Briggs Institute reviewers manual:2016 edition[M].Australia:The Joanna Briggs Institute, 2016.
    [23]
    SIEGEL RL, MILLER KD, JEMAL A. Cancer statistics, 2018[J]. CA Cancer J Clin, 2018, 68(1):7-30. DOI: 10.3322/caac.21442.
    [24]
    郑荣寿, 孙可欣, 张思维, 等.2015年中国恶性肿瘤流行情况分析[J].中华肿瘤杂志, 2019, 41(1):19-28. DOI: 10.3760/cma.j.issn.0253-3766.2019.01.005.

    ZHENG RS, SUN KX, ZHANG SW, et al. Report of cancer epidemiology in China, 2015[J]. Chin J Oncol, 2019, 41(1):19-28.DOI:10.3760/cma.j.issn.0253- 3766.2019.01.005.
    [25]
    WATT KD, PEDERSEN RA, KREMERS WK, et al. Evolution of causes and risk factors for mortality post-liver transplant: results of the NIDDK long-term follow-up study[J]. Am J Transplant, 2010, 10(6):1420-1427. DOI: 10.1111/j.1600-6143.2010.03126.x.
    [26]
    PARK HW, HWANG S, AHN CS, et al. De novo malignancies after liver transplantation: incidence comparison with the Korean cancer registry[J]. Transplant Proc, 2012, 44(3):802-805. DOI: 10.1016/j.transproceed.2012.01.027.
    [27]
    RADEMACHER S, SEEHOFER D, EURICH D, et al. The 28-year incidence of de novo malignancies after liver transplantation: a single-center analysis of risk factors and mortality in 1 616 patients[J]. Liver Transpl, 2017, 23(11):1404-1414. DOI: 10.1002/lt.24795.
    [28]
    WATT KD, PEDERSEN RA, KREMERS WK, et al. Long-term probability of and mortality from de novo malignancy after liver transplantation[J]. Gastroenterology, 2009, 137(6):2010-2017. DOI: 10.1053/j.gastro.2009.08.070.
    [29]
    BACCARANI U, PISELLI P, SERRAINO D, et al. Comparison of de novo tumours after liver transplantation with incidence rates from Italian cancer registries[J]. Dig Liver Dis, 2010, 42(1):55-60. DOI: 10.1016/j.dld.2009.04.017.
    [30]
    CARENCO C, FAURE S, HERRERO A, et al. Incidence of solid organ cancers after liver transplantation: comparison with regional cancer incidence rates and risk factors[J]. Liver Int, 2015, 35(6):1748-1755. DOI: 10.1111/liv.12758.
    [31]
    LUCEY MR, TERRAULT N, OJO L, et al. Long-term management of the successful adult liver transplant: 2012 practice guideline by the American Association for the Study of Liver Diseases and the American Society of Transplantation[J]. Liver Transpl, 2013, 19(1):3-26. DOI: 10.1002/lt.23566.
    [32]
    JUNG DH, HWANG S, SONG GW, et al. Survival benefit of early cancer detection through regular endoscopic screening for de novo gastric and colorectal cancers in Korean liver transplant recipients[J]. Transplant Proc, 2016, 48(1):145-151. DOI: 10.1016/j.transproceed.2015.12.003.
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