Research progress of HO-1 and autophagy in hepatic ischemia-reperfusion injury

Gan Xiaojie; Gu Jian; Lyu Ling

doi:10.3969/j.issn.1674-7445.2020.01.018

Volume 11 Issue 1

Jan. 2020

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Gan Xiaojie, Gu Jian, Lyu Ling. Research progress of HO-1 and autophagy in hepatic ischemia-reperfusion injury[J]. ORGAN TRANSPLANTATION, 2020, 11(1): 110-114. doi: 10.3969/j.issn.1674-7445.2020.01.018

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Research progress of HO-1 and autophagy in hepatic ischemia-reperfusion injury

doi: 10.3969/j.issn.1674-7445.2020.01.018

Hepatobiliary Center, the First Affiliated Hospital of Nanjing Medical University, Key Laboratory of Liver Transplantation of Chinese Academy of Medical Sciences, Key Laboratory of Living Liver Transplantation of National Health Commission of the People's Republic of China, Nanjing 210029, China

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Corresponding author: Lyu Ling, Email: lvling@njmu.edu.cn
Received Date: 2019-09-19
Available Online: 2021-01-19
Publish Date: 2020-01-15

Abstract

Abstract

Heme oxygenase (HO)-1 and its enzymolysis products can mitigate hepatic ischemia-reperfusion injury (HIRI) by alleviating the damage of reactive oxygen free radicals, mitigating cell apoptosis, inhibiting inflammatory reaction and maintaining microcirculation stability. Autophagy is a process in which the cells utilize lysosomes to degrade their damaged organelles and macromolecular substances. It is considered as an adaptive response to alleviate cell damage under stress, which can effectively reduce cell death. In recent years, more and more studies have demonstrated that autophagy is also significantly correlated with HIRI. This article reviewed recent research progresses at home and abroad on HO-1 and HIRI, autophagy and HIRI, the interaction and mechanism between HO-1 and autophagy in HIRI.
- Heme oxygenase-1,
- Autophagy,
- Ischemia-reperfusion injury,
- Liver transplantation,
- Heat shock protein,
- Interferon,
- Interleukin,
- Inflammation

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References(40)

References

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Research progress of HO-1 and autophagy in hepatic ischemia-reperfusion injury

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