Volume 10 Issue 4
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Wang Jianfu, Deng Gengguo, Zhu Chunli, et al. Clinical study of value of serum Klotho level of elderly donors in predicting postoperative renal graft function in recipients[J]. ORGAN TRANSPLANTATION, 2019, 10(4): 439-442. doi: 10.3969/j.issn.1674-7445.2019.04.015
Citation: Wang Jianfu, Deng Gengguo, Zhu Chunli, et al. Clinical study of value of serum Klotho level of elderly donors in predicting postoperative renal graft function in recipients[J]. ORGAN TRANSPLANTATION, 2019, 10(4): 439-442. doi: 10.3969/j.issn.1674-7445.2019.04.015
shu

Clinical study of value of serum Klotho level of elderly donors in predicting postoperative renal graft function in recipients

doi: 10.3969/j.issn.1674-7445.2019.04.015

  • Department of Organ Transplantation, Guangdong Second Provincial People's Hospital, Guangzhou 510317, China

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  • Corresponding author: Liu Dong, Email:Ld177@163.com
  • Received Date: 2019-05-30
    Available Online: 2021-01-19
  • Publish Date: 2019-07-15
    Abstract
  •   Objective  To explore the feasibility of serum Klotho level in the elderly donors to predict the renal graft function in the recipients.  Methods  Clinical data of 16 elderly donors and 27 recipients undergoing renal transplantation were collected. The general status of the recipients was observed. The levels of serum Klotho and serum creatinine (Scr) in the elderly donors were measured on the day of renal transplantation. The Scr levels in the recipients were measured at postoperative 1, 3 and 12 months respectively. The estimated glomerular filtration rate (eGFR) was calculated. The correlation between the serum Klotho level of the donors and postoperative graft function of the recipients was analyzed.  Results  The cold ischemia time during renal transplantation was (649±245) min. The incidence rate of delayed graft function (DGF) was 26%. The incidence rate of acute rejection was 7%. In the elderly donors, the serum Klotho level was 537 (245-793) pg/mL and the Scr level was (164±62) μmol/L. At postoperative 1, 3 and 12 months, the Scr levels in the recipients were (136±47), (132±43) and (133±46) μmol/L, respectively. The corresponding eGFR was (52±20), (52±19) and (53±21) mL/(min?1.73m2), respectively. The serum Klotho level in the elderly donors was negatively correlated with the renal graft function at postoperative 1 month in the recipients (P < 0.05). The sensitivity and specificity of serum Klotho level in predicting the renal graft insufficiency at postoperative 1 month were 0.909 and 0.769.  Conclusions  The preoperative serum Klotho level in the elderly donors have predictive value for renal graft function in the recipients at postoperative 1 month.

     

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    • References(24)
  • [1]
    LE MEUR Y. What immunosuppression should be used for old-to-old recipients?[J]. Transplant Rev (Orlando), 2015, 29(4):231-236. DOI: 10.1016/j.trre.2015.08.004.
    [2]
    郭晖, 陈知水, 陈实.公民逝世后器官捐献供肾的病理学评估[J].器官移植, 2018, 9(1):1-8.DOI: 10.3969/j.issn.1674-7445.2018.01.001.

    GUO H, CHEN ZS, CHEN S. Pathological evaluation of donor kidneys in donation after citizen's death [J].Organ Transplant, 2018, 9(1):1-8. DOI: 10.3969/j.issn.1674-7445.2018.01.001.
    [3]
    KURO-O M, MATSUMURA Y, AIZAWA H, et al. Mutation of the mouse Klotho gene leads to a syndrome resembling ageing[J]. Nature, 1997, 390(6655):45-51. doi: 10.1038/36285
    [4]
    LINDBERG K, AMIN R, MOE OW, et al. The kidney is the principal organ mediating Klotho effects[J]. J Am Soc Nephrol, 2014, 25(10):2169-2175. DOI: 10.1681/ASN.2013111209.
    [5]
    SEO MY, YANG J, LEE JY, et al. Renal Klotho expression in patients with acute kidney injury is associated with the severity of the injury[J]. Korean J Intern Med, 2015, 30(4):489-495. DOI: 10.3904/kjim.2015.30.4.489.
    [6]
    HU MC, MOE OW. Klotho as a potential biomarker and therapy for acute kidney injury[J]. Nat Rev Nephrol, 2012, 8(7):423-429. DOI: 10.1038/nrneph.2012.92.
    [7]
    KUSABA T, LALLI M, KRAMANN R, et al. Differentiated kidney epithelial cells repair injured proximal tubule[J]. Proc Natl Acad Sci U S A, 2014, 111(4):1527-1132. DOI: 10.1073/pnas.1310653110.
    [8]
    HUMPHREYS BD, CZERNIAK S, DIROCCO DP, et al.Repair of injured proximal tubule does not involve specialized progenitors[J]. Proc Natl Acad Sci U S A, 2011, 108(22):9226-9231. DOI: 10.1073/pnas.1100629108.
    [9]
    SUSNIK N, MELK A, SCHMITT R. Cell aging and kidney repair[J]. Cell Cycle, 2015, 14(22):3521-3522. DOI: 10.1080/15384101.2015.1032636.
    [10]
    GE S, NIE S, LIU Z, et al. Epidemiology and outcomes of acute kidney injury in elderly Chinese patients: a subgroup analysis from the EACH study[J]. BMC Nephrol, 2016, 17(1):136. doi: 10.1186/s12882-016-0351-2
    [11]
    SCHMITT R, COCA S, KANBAY M, et al. Recovery of kidney function after acute kidney injury in the elderly:a systematic review and Meta-analysis[J]. Am J KidneyDis, 2008, 52(2):262-271. DOI: 10.1053/j.ajkd.2008.03.005.
    [12]
    KOYAMA D, SATO Y, AIZAWA M, et al. Soluble αKlotho as a candidate for the biomarker of aging[J]. Biochem Biophys Res Commun, 2015, 467(4):1019-1025. DOI: 10.1016/j.bbrc.2015.10.018.
    [13]
    HUANG J, WANG H, FAN ST, et al. The national program for deceased organ donation in China[J]. Transplantation, 2013, 96(1):5-9. DOI: 10.1097/TP.0b013e3182985491.
    [14]
    CHEN GD, SHIU-CHUNG KO D, WANG CX, et al. Kidney transplantation from donors after cardiac death: an initial report of 71 cases from China[J]. Am J Transplant, 2013, 13(5):1323-1326. DOI: 10.1111/ajt.12190.
    [15]
    AUBERT O, KAMAR N, VERNEREY D, et al. Long term outcomes of transplantation using kidneys from expanded criteria donors: prospective, population based cohort study[J]. BMJ, 2015, 351:h3557. DOI: 10.1136/bmj.h3557.
    [16]
    BRAT A, POL RA, LEUVENINK HG. Novel preservation methods to increase the quality of older kidneys[J]. Curr Opin Organ Transplant, 2015, 20(4):438-443. DOI: 10.1097/MOT.0000000000000215.
    [17]
    DREW DA, KATZ R, KRITCHEVSKY S, et al. Association between soluble Klotho and change in kidney function: the health aging and body composition study[J]. J Am Soc Nephrol, 2017, 28(6):1859-1866. DOI: 10.1681/ASN.2016080828.
    [18]
    CASTELLANO G, INTINI A, STASI A, et al. Complement modulation of anti-aging factor Klotho in ischemia/reperfusion injury and delayed graft function[J]. Am J Transplant, 2016, 16(1):325-333. DOI: 10.1111/ajt.13415.
    [19]
    SEIBERT E, RADLER D, ULRICH C, et al. Serum Klotho levels in acute kidney injury[J]. Clin Nephrol, 2017, 87(4):173-179. DOI: 10.5414/CN108970.
    [20]
    PANAH F, GHORBANIHAGHJO A, ARGANI H, et al.Ischemic acute kidney injury and Klotho in renal transplantation[J]. Clin Biochem, 2018, 55:3-8. DOI: 10.1016/j.clinbiochem.2018.03.022.
    [21]
    MEYFROIDT G, GUNST J, MARTIN-LOECHES I, et al. Management of the brain-dead donor in the ICU: general and specific therapy to improve transplantable organ quality[J]. Intensive Care Med, 2019, 45(3):343-353. DOI: 10.1007/s00134-019-05551-y.
    [22]
    HELANTERÄ I, HONKANEN E, HUHTI J, et al. Living donor kidney transplantation[J]. Duodecim, 2017, 133(10):937-944. http://d.old.wanfangdata.com.cn/Periodical/zhqgyz98200605003
    [23]
    SUTHERLAND AI, IJZERMANS JN, FORSYTHE JL, et al. Kidney and liver transplantation in the elderly[J]. Br J Surg, 2016, 103(2):e62-e72. DOI: 10.1002/bjs.10064.
    [24]
    ROSTAING L. Renal transplantation[J]. Nephrol Ther, 2017, 13(6S):6S25-6S29. DOI: 10.1016/S1769-7255(18)30037-3.
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