Volume 9 Issue 4
Jul.  2018
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Article Navigation >  ORGAN TRANSPLANTATION  > 2018  >  9(4): 268-271, 277
Ding Hao, Mao Wenjun, Liu Feng, et al. Long-term survival of bilateral lung transplantation combined with Nuss operation on treatment of bronchiolitis obliterans syndrome complicated with thoracic deformity after hematopoietic stem cell transplantation: report of one case[J]. ORGAN TRANSPLANTATION, 2018, 9(4): 268-271, 277. doi: 10.3969/j.issn.1674-7445.2018.04.005
Citation: Ding Hao, Mao Wenjun, Liu Feng, et al. Long-term survival of bilateral lung transplantation combined with Nuss operation on treatment of bronchiolitis obliterans syndrome complicated with thoracic deformity after hematopoietic stem cell transplantation: report of one case[J]. ORGAN TRANSPLANTATION, 2018, 9(4): 268-271, 277. doi: 10.3969/j.issn.1674-7445.2018.04.005
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Long-term survival of bilateral lung transplantation combined with Nuss operation on treatment of bronchiolitis obliterans syndrome complicated with thoracic deformity after hematopoietic stem cell transplantation: report of one case

doi: 10.3969/j.issn.1674-7445.2018.04.005

  • Department of Thoracic Surgery and Lung Transplantation Center, Wuxi People' s Hospital Affiliated to Nanjing Medical University, Wuxi 214023, China

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  • Corresponding author: Chen Jingyu,Email：chenjingyu333@sina.com
  • Received Date: 2018-05-06
    Available Online: 2021-01-19
  • Publish Date: 2018-07-15
    Abstract
  •   Objective  To evaluate the clinical efficacy of bilateral lung transplantation combined with Nuss operation on the treatment of bronchiolitis obliterans syndrome (BOS) complicated with pectus excavatum after hematopoietic stem cell transplantation.  Methods  On March 24, 2015, one patient presenting with BOS complicated with pectus excavatum after hematopoietic stem cell transplantation underwent extracorporeal membrane oxygenation (ECMO)-assisted bilateral lung transplantation in the Department of Thoracic Surgery and Lung Transplantation Center of Wuxi People' s Hospital affiliated to Nanjing Medical University. Simutaneously, Nuss operation was successfully performed to treat pectus excavatum. After anti-inflammation and anti-fungal treatment, a triple immunosuppressive regimen consisting of tacrolimus + mycophenolate mofetil + adrenocortical hormone was implemented.  Results  The patient was properly recovered and discharged on 25 d after operation. The Nuss steel plate was removed from the chest at postoperative 2 years. The thoracic deformity was corrected. The patient received long-term postoperative follow-up. Until submission date, the patient survived for more than 3 years. The lung function was well restored and the quality of life was satisfactory.  Conclusions  Bilateral lung transplantation combined with Nuss operation is an effective approach in the treatment of end-stage BOS complicated thoracic deformity.

     

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