Volume 9 Issue 4
Jul.  2018
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Article Navigation >  ORGAN TRANSPLANTATION  > 2018  >  9(4): 261-267
Liu Qiang, Luo Fangbiao, Yan Xiong, et al. Clinical efficacy of ABO-incompatible living donor liver transplantation: a Meta analysis[J]. ORGAN TRANSPLANTATION, 2018, 9(4): 261-267. doi: 10.3969/j.issn.1674-7445.2018.04.004
Citation: Liu Qiang, Luo Fangbiao, Yan Xiong, et al. Clinical efficacy of ABO-incompatible living donor liver transplantation: a Meta analysis[J]. ORGAN TRANSPLANTATION, 2018, 9(4): 261-267. doi: 10.3969/j.issn.1674-7445.2018.04.004
shu

Clinical efficacy of ABO-incompatible living donor liver transplantation: a Meta analysis

doi: 10.3969/j.issn.1674-7445.2018.04.004

  • Department of Hepatobiliary Surgery, the First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China

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  • Corresponding author: Du Chengyou,Email：duchengyou@126.com
  • Received Date: 2018-04-13
    Available Online: 2021-01-19
  • Publish Date: 2018-07-15
    Abstract
  •   Objective  To systematically evaluate the clinical efficacy of ABO-incompatible living donor liver transplantation (ABO-I LDLT) and compare with ABO-compatible LDLT (ABO-C LDLT).  Methods  A systematic search of multiple databases at home and abroad was conducted to retrieve the literatures related to the statistical comparison of clinical efficacy between ABO-I LDLT and ABO-C LDLT. The literature screening was conducted, the quality of literatures was evaluated and data extraction was performed. Using Rev Man 5.3 software, a Meta-analysis was performed by random effect model or fixed effect model.  Results  A total of 432 articles were searched, and 6 articles published in English were eventually included according to the inclusion criteria. The Meta-analysis demonstrated that there was no significant difference in the postoperative 1-, 3- and 5-year survival rate of the recipients and grafts and the incidence of rejection responses between the ABO-I LDLT and ABO-C LDLT groups (all P≥0.05). The incidence of postoperative biliary complications and hepatic artery embolization in the ABO-I LDLT group was significantly higher than that in the ABO-C LDLT group [odds ratio (OR) =2.08, 95% confidence interval (CI) 1.25-3.45, P=0.005; OR=2.24, 95%CI 1.03-4.89, P=0.04].  Conclusions  Compared with the ABO-C LDLT, ABO-I LDLT yields lower clinical efficacy, whereas it is still an effective method for the treatment of end-stage liver disease.

     

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