Volume 8 Issue 6
Nov.  2017
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Article Navigation >  ORGAN TRANSPLANTATION  > 2017  >  8(6): 455-459
Liao Qi, Jiang Qiuyan, Xiong Yan, et al. Clinical observation on the removal of donor specific antibody by double filtration plasmapheresis in renal transplant recipients[J]. ORGAN TRANSPLANTATION, 2017, 8(6): 455-459. doi: 10.3969/j.issn.1674-7445.2017.06.009
Citation: Liao Qi, Jiang Qiuyan, Xiong Yan, et al. Clinical observation on the removal of donor specific antibody by double filtration plasmapheresis in renal transplant recipients[J]. ORGAN TRANSPLANTATION, 2017, 8(6): 455-459. doi: 10.3969/j.issn.1674-7445.2017.06.009
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Clinical observation on the removal of donor specific antibody by double filtration plasmapheresis in renal transplant recipients

doi: 10.3969/j.issn.1674-7445.2017.06.009

  • Department of Nephrology, the 181st Hospital of People's Liberation Army, Organ Transplantation and Dialysis Treatment Center of People's Liberation Army, Guangxi Key Laboratory of Metabolic Disease Research, Guilin 541002, China

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  • Corresponding author: Zou Guimian, Email: zougm2004@126.com
  • Received Date: 2017-08-08
    Available Online: 2021-01-19
  • Publish Date: 2017-11-15
    Abstract
  •   Objective  To investigate the effect of double filtration plasmapheresis (DFPP) upon the removal of donor specific antibody (DSA) in highly sensitized recipients with renal transplantation.  Methods  Four highly sensitized recipients undergoing renal transplantation received 7 cycles of DFPP. Luminex technology was adopted to monitor the changes of DSA. Clinical efficacy, incidence of acute rejection and adverse reactions were observed.  Results  After DFPP, the DSA MFI [1 036 (0-4 113)] was significantly declined than that before treatment [6 446 (2 999-12 905), Z=-2.503, P=0.012]. No hyperacute rejections occurred in four highly sensitized recipients undergoing renal transplantation. Acute rejection was noted in one case, which was mitigated by postoperative DFPP and adjustment of immunosuppressive agents. During postoperative follow-up, the function of transplant kidney was normal and no rejection reactions occurred. The level of albumin was decreased after DFPP.  Conclusions  DFPP can effectively remove the DSA in the recipients. It is an efficacious and safe approach to prevent the incidence of acute rejections in highly sensitized recipients after renal transplantation.

     

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