Volume 8 Issue 6
Nov.  2017
Turn off MathJax
Article Contents
Article Navigation >  ORGAN TRANSPLANTATION  > 2017  >  8(6): 430-434
Ding Limin, Xu Zhidan, Li Xinchang, et al. Clinical analysis on donor liver protection and function evaluation for organ donation after citizen's death[J]. ORGAN TRANSPLANTATION, 2017, 8(6): 430-434. doi: 10.3969/j.issn.1674-7445.2017.06.004
Citation: Ding Limin, Xu Zhidan, Li Xinchang, et al. Clinical analysis on donor liver protection and function evaluation for organ donation after citizen's death[J]. ORGAN TRANSPLANTATION, 2017, 8(6): 430-434. doi: 10.3969/j.issn.1674-7445.2017.06.004
shu

Clinical analysis on donor liver protection and function evaluation for organ donation after citizen's death

doi: 10.3969/j.issn.1674-7445.2017.06.004

  • Department of Organ Transplantation, Jiangxi Provincial People's Hospital, Nanchang 330006, China

More Information
  • Corresponding author: Xu Zhidan, Email: xuzhidan1970@163.com
  • Received Date: 2017-07-31
    Available Online: 2021-01-19
  • Publish Date: 2017-11-15
    Abstract
  •   Objective  To summarize the preliminary experience of donor liver protection and function evaluation for organ donation after citizen's death.  Methods  Clinical data of 35 donors from organ donation after citizen's death and 33 recipients were retrospectively analyzed. Donor liver procurement and clinical prognosis of the recipients were summarized. According to serum level of sodium ion (serum sodium) before organ procurement, all recipients were divided into the serum sodium < 155 mmol/L, 155-160 mmol/L and 161-180 mmol/L groups. The incidence of liver graft dysfunction early after liver transplantation was statistically compared among three groups.  Results  In 35 donors, 27 cases were Chinese type Ⅱ and 8 cases were Chinese type Ⅲ. Thirty-three donor livers were used for liver transplantation, and the remaining 2 cases of donor livers were excluded due to congestive cirrhosis. In 33 liver transplantation recipients, 30 cases were successfully recovered. The liver function was gradually restored at postoperative 7-14 d, and normal liver function was obtained during long-term follow-up. Postoperatively, 3 recipients died including 2 cases dying from portal vein thrombosis and 1 case from pulmonary infection complicated with multiple organ failure. The incidence of early liver graft dysfunction of the recipients after liver transplantation was 18%, 23% and 4/5 in the serum sodium < 155 mmol/L, 155-160 mmol/Land 161-180 mmol/L groups, respectively. Statistical significance was observed between the 161-180 mmol/L and < 155 mmol/L groups (P < 0.05).  Conclusions  Timely protection of donor liver, accurate evaluation and maintenance of liver function play a pivotal role in enhancing the utilization rate of donor liver, maintaining liver function and yielding good efficacy for transplantation.

     

    • FullText(HTML)
  • loading
    • References(16)
  • [1]
    霍枫.公民心脏死亡器官捐献开启我国器官移植新时代[J].器官移植, 2013, 4(5): 247-249. DOI: 10.3969/j.issn.1674-7445.2013.05.001.

    Huo F. New time of organ transplantation started by donation after cardiac death of citizens in China[J]. Organ Transplant, 2013, 4(5): 247-249. DOI: 10.3969/j.issn.1674-7445.2013.05.001.
    [2]
    Chamorro C, Falcón JA, Michelena JC. Controversial points in organ donor management[J]. Transplant Proc, 2009, 41(8):3473-3475. DOI: 10.1016/j.transproceed.2009.09.004.
    [3]
    王光策, 王锁刚, 张翥, 等.脑死亡器官捐献移植过程中的问题[J].中国组织工程研究与临床康复, 2011, 15(18): 3280-3283. DOI: 10.3969/j.issn.1673-8225. 2011.18.013.

    Wang GC, Wang SG, Zhang Z, et al. Several problems in brain-dead donor kidney transplantation[J]. J Clin Rehabil Tissue Eng Res, 2011, 15(18): 3280-3283. DOI: 10.3969/j.issn.1673-8225. 2011.18.013.
    [4]
    López-Navidad A, Caballero F, Guirado L, et a1. The medical-nursing team specialized in the maintenance of the brain-dead heart-beating organ donor exclusively dedicated to caring for the donor reduces donor loss from asystolia to zero[J]. Transplant Proc, 2002, 34(1): 20-22. doi: 10.1016/S0041-1345(01)02826-3
    [5]
    Desai CJ. Selection and maintenance of a cadaver donor for liver transplantation[J]. Apollo Med, 2012, 9(1): 9-16. doi: 10.1016/S0976-0016(12)60114-8
    [6]
    王钢, 周洪澜, 王伟刚, 等. 心脏死亡器官捐献供体维护的体会[J/CD]. 实用器官移植电子杂志, 2013, 1(5): 282-285. DOI: 10.3969/j.issn.2095-5332.2013.05.003.

    Wang G, Zhou HL, Wang WG, et al. The experience for maintenance of cardiac death organ donation[J/CD]. Pract J Organ Transplant (Elect Vers), 2013, 1(5): 282-285. DOI: 10.3969/j.issn.2095-5332.2013.05.003.
    [7]
    杨顺良, 谭建明.潜在脑死亡捐献者的器官维护[J].器官移植, 2015, 6(5): 288-293. DOI: 10.3969/j.issn.1674-7445.2015.05.002.

    Yang SL, Tan JM. Organ maintenance of potential brain death donors[J]. Organ Transplant, 2015, 6(5): 288-293. DOI: 10.3969/j.issn.1674-7445.2015.05.002.
    [8]
    中华医学会器官移植学分会, 中华医学会外科学分会移植学组, 中国医师协会器官移植医师分会. 中国心脏死亡捐献器官评估与应用专家共识[J/CD]. 中华移植杂志(电子版), 2014, 8(3): 117-122. DOI: 10.3877/cma.j.issn.1647-3903.2014.03.001.

    Branch of Organ Transplantation of Chinese Medical Association, Transplantation Group in Branch of Surgery of Chinese Medical Association, Branch of Organ Transplant Physician of Chinese Medical Doctor Association. Expert consensus on evaluation and application of organ donated after cardiac death in China[J/CD]. Chin J Transplant (Elect Vers), 2014, 8(3): 117-122. DOI: 10.3877/cma.j.issn.1647-3903.2014.03.001.
    [9]
    魏来, 张波, 陈知水.中国移植器官保护专家共识(2016版)解读[J].临床外科杂志, 2017, 25(1): 26-29. DOI: 10.3969/j.issn.1005-6483.2017.01.006.

    Wei L, Zhang B, Chen ZS. Interpretation for the expert consensus on the protection of transplant organ in China (2016)[J]. J Clin Surg, 2017, 25(1): 26-29. DOI: 10.3969/j.issn.1005-6483.2017.01.006.
    [10]
    中华医学会器官移植学分会, 中国医师协会器官移植医师分会. 中国公民逝世后捐献供器官功能评估和维护专家共识(2016版)[J/CD]. 中华移植杂志(电子版), 2016, 10(4): 145-153. DOI: 10.3877/cma.j.issn.1674-3903.2016.04.001.

    Branch of Organ Transplantation of Chinese Medical Association, Branch of Organ Transplant Physician of Chinese Medical Doctor Association. Expert consensus on evaluation and maintenance of organ donated after citizens death in China (2016)[J/CD]. Chin J Transplant (Elect Vers), 2016, 10(4): 145-153. DOI: 10.3877/cma.j.issn.1674-3903.2016.04.001.
    [11]
    李晓璟, 叶啟发, 明英姿, 等.心脏死亡供肝肝移植疗效进展[J].中华医学杂志, 2016, 96(8): 666-668. DOI: 10.3760/cma.j.issn.0376-2491.2016.08.021.

    Li XJ, Ye QF, Ming YZ, et al. Advance on the the therapeutic effect of liver transplantation from donation after cardiac death[J]. Natl Med J China, 2016, 96(8): 666-668. DOI: 10.3760/cma.j.issn.0376-2491.2016.08.021.
    [12]
    Mathur AK, Heimbach J, Steffick DE, et a1. Donation after cardiac death liver transplantation: predictors of outcome[J]. Am J Transplant, 2010, 10(11): 2512-2519. DOI: 10.1111/j.1600-6143.2010.03293.x.
    [13]
    Karp SJ, Johnson S, Evenson A, et a1. Minimising cold ischaemic time is essential in cardiac death donor-associated liver transplantation[J]. HPB (Oxford), 2011, 13(6): 411-416.DOI: 10.1111/j.1477-2574.2011.00307.x.
    [14]
    王泽惠, 王永进, 侯云生, 等.心肺复苏后多器官功能障碍综合征临床分析[J].中国急救医学, 2005, 25(8): 609-610.DOI: 10.3969/j.issn.1002-1949.2005. 08.027.

    Wang ZH, Wang YJ, Hou YS, et al. Clinical analysis of multiple organ dysfunction syndrome after cardiopulmonary resuscitation[J]. Chin J Crit Care Med, 2005, 25(8): 609-610. DOI: 10.3969/j.issn.1002-1949.2005. 08.027.
    [15]
    Totsuka E, Dodson F, Urakami A, et al. Influence of high donor serum sodium levels on early postoperative graft function in human liver transplantation: effect of correction of donor hypernatremia[J]. Liver Transpl Surg, 1999, 5(5): 421-428. DOI: 10.1002/lt.500050510.
    [16]
    时军, 罗文峰, 丁利民, 等.脑死亡儿童供肝成人移植临床分析[J].中华肝胆外科杂志, 2011, 17(5): 359-363. DOI: 10.3760/cma.j.issn.1007-8118.2011.05.004.

    Shi J, Luo WF, Ding LM, et al. Clinical analysis of liver transplant from a child of brain death to an adult[J]. Chin J Hepatobiliary Surg, 2011, 17(5): 359-363. DOI: 10.3760/cma.j.issn.1007-8118.2011.05.004.
    • Relative Articles
    • Supplements(0)
    • Cited By
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索
    Get Citation
    PDF
    XML

    Article Metrics

    Article views (118) PDF downloads(11) Cited by()
    Proportional views
    Related

    WeChat Subscription Account

    Wechat Service Account

    Contact Us
    • Tel：020-38736410
    • Email: organtranspl@163.com
    • Address：The Third Affiliated Hospital of Sun Yat-sen University, No. 600, Tianhe Road, Tianhe District, Guangzhou
    • Editorial Office of Organ Transplantation  粤ICP备2021030844号
    Links

    Supported by: Beijing Renhe Information Technology Co. Ltd    

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return