Analysis of risk factors of initial poor graft function after living donor liver transplantation

  Objective   To identify the risk factors of the incidence rate of initial poor graft function (IPGF) in recipients after living donor liver transplantation.

  Methods   Clinical data of 309 patients undergoing living donor liver transplantation were retrospectively analyzed. Candidate risk factors: (1) donor factors included age, gender and body mass index (BMI); (2) recipient factors included age, gender, BMI and preoperative Child-Pugh classification, model for end-stage liver disease (MELD) grading, preoperative renal insufficiency, serum total bilirubin elevation, hyponatremia and hypopotassaemia; (3) graft factors included graft cold ischemia time, graft recipient weight ratio (GRWR); (4) recipient surgery factors included total operation time, blood loss volume, blood transfusion volume, platelet transfusion and anhepatic phase≥100 min. Single factor analysis was performed to identify the potential risk factors of IPGF. Logistic regression analysis was conducted to explore independent risk factors.

  Results   and

  Conclusions   Child-Pugh C of preoperative recipient liver function, MELD score≥20, serum total bilirubin elevation(>68.4 μmol/L), hyponatremia(＜135 mmol/L), hypopotassaemia (＜3.5 mmol/L) and anhepatic phase≥100 min were potential risk factors of IPGF (all P＜0.05). Child-Pugh C of preoperative recipient liver function was an independent risk factor of the incidence rate of IPGF following living donor liver transplantation (P=0.019).