Volume 7 Issue 4
Jul.  2016
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Hu Weiyu, Wang Jianhong, Hu Xiao, et al. Relationship between the mid-term hepatic hemodynamics and abnormal liver function after liver transplantation[J]. ORGAN TRANSPLANTATION, 2016, 7(4): 296-300. doi: 10.3969/j.issn.1674-7445.2016.04.010
Citation: Hu Weiyu, Wang Jianhong, Hu Xiao, et al. Relationship between the mid-term hepatic hemodynamics and abnormal liver function after liver transplantation[J]. ORGAN TRANSPLANTATION, 2016, 7(4): 296-300. doi: 10.3969/j.issn.1674-7445.2016.04.010
shu

Relationship between the mid-term hepatic hemodynamics and abnormal liver function after liver transplantation

doi: 10.3969/j.issn.1674-7445.2016.04.010

  • Department of Hepatopancreatobiliary Surgery, the Affiliated Hospital of Qingdao University, Qingdao 266000, China

  • Received Date: 2016-04-05
    Available Online: 2021-01-19
  • Publish Date: 2016-07-15
    Abstract
  •   Objective  To analyze the law of the mid-term hepatic hemodynamics after liver transplantation and to investigate its relationship with liver function.   Methods  A total of 56 recipients underwent liver transplantation in the Affiliated Hospital of Qingdao University from February 2014 to October 2015 were studied, and divided into normal group (n=24) and abnormal group (n=32) according to the liver function. General information and liver function of both groups were recorded. Furthermore, hepatic artery peak velocity (HAP), portal vein peak velocity (PVP) and portal vein flow (PVF) before the liver transplantation and on postoperative day 1, 30 and 90 were measured through ultrasonic detection; hepatic arterial buffer capacity (BC) and adjustment BC were calculated. The univariable and multivariable analysis were performed to analyze the relationship between hepatic hemodynamics and liver function in two groups, and the receiver operating curve (ROC) was drawn.   Results  The PVP and PVF on postoperative day 30 in abnormal group were significantly higher than those of normal group (P=0.014, 0.049). The BC and adjustment BC in normal group were significantly higher than those of abnormal group (P=0.048, 0.011). The multivariable analysis showed that adjustment BC was the independent risk factor (P=0.047), with the area under the curve (AUC) of ROC of 0.705, sensitivity of 0.652 and specificity of 0.750.   Conclusion  PVP, PVF, BC and adjustment BC on postoperative day 30 may be related to abnormal liver function, of which adjustment BC can be used as one of the indicators for diagnosis and intervention of abnormal liver function.

     

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