Volume 6 Issue 6
Nov.  2015
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Yang Fan, Zheng Xiaofang, Liu Chang, et al. Curative effect and safety of haploidentical allogeneic cytokine-induced killer in treatment of advanced hepatocellular carcinoma[J]. ORGAN TRANSPLANTATION, 2015, 6(6): 405-409. doi: 10.3969/j.issn.1674-7445.2015.06.012
Citation: Yang Fan, Zheng Xiaofang, Liu Chang, et al. Curative effect and safety of haploidentical allogeneic cytokine-induced killer in treatment of advanced hepatocellular carcinoma[J]. ORGAN TRANSPLANTATION, 2015, 6(6): 405-409. doi: 10.3969/j.issn.1674-7445.2015.06.012
shu

Curative effect and safety of haploidentical allogeneic cytokine-induced killer in treatment of advanced hepatocellular carcinoma

doi: 10.3969/j.issn.1674-7445.2015.06.012

  • Biological Treatment Center, Guangdong Key Laboratory of Ordinary Colleges and Universities of Biological Treatment of Liver Disease Clinical Transformation, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China

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  • Corresponding author: Zhang Qi, Email: keekee77@126.com
  • Received Date: 2015-08-28
    Available Online: 2021-01-19
  • Publish Date: 2015-11-15
    Abstract
  •   Objective  To investigate the curative effect and safety of haploidentical allogeneic cytokine-induced killer (CIK) in treatment of advanced hepatocellular carcinoma.  Methods  The peripheral blood mononuclear cell (PBMC) of the healthy immediate family members of 21 patients with advanced hepatocellular carcinoma (HCC) were collected, induced into haploidentical allogeneic CIK in vitro and transfused to the patients for 4 cycles. The curative effect and safety were assessed.  Results  The 21 patients were followed up for half a year. The survival rate was 81% (17/21). Among the 21 patients, 11 cases were with stable disease and 10 cases were with progressive disease(including 4 dead cases). Six patients developed fever of different degrees during the treatment and one patient developed rash. The platelet counts of the patients at the fourth cycle after the treatment decreased compared with that before the treatment, with significance difference (P < 0.05). The difference in leukocytes, neutrophils, lymphocytes, hemoglobin, liver function and renal function at the first and fourth cycle after the treatment had no statistical significance (all in P>0.05).  Conclusions  Haploidentical allogeneic CIK in treatment of advanced HCC may effectively improve the quality of life and the adverse reactions are tolerable, which is a relatively safe therapy.

     

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    • References(18)
  • [1]
    Jäkel CE, Schmidt-Wolf IG. An update on new adoptive immunotherapy strategies for solid tumors with cytokine-induced killer cells[J]. Expert Opin Biol Ther, 2014, 14(7):905-916. doi: 10.1517/14712598.2014.900537
    [2]
    Yu X, Zhao H, Liu L, et al. A randomized phase Ⅱ study of autologous cytokine-induced killer cells in treatment of hepatocellular carcinoma[J]. J Clin Immunol, 2014, 34(2):194-203. doi: 10.1007/s10875-013-9976-0
    [3]
    Yan CX, Zhang HM, Chen R, et al. Adverse reactions and their management in the treatment of malignant tumors using cytokine-induced killer cells[J]. Ann Palliat Med, 2013, 2(2):85-89. http://cn.bing.com/academic/profile?id=125564733&encoded=0&v=paper_preview&mkt=zh-cn
    [4]
    Chen R, Deng X, Wu H, et al. Combined immunotherapy with dendritic cells and cytokine-induced killer cells for malignant tumors:a systematic review and meta-analysis[J]. Int Immunopharmacol, 2014, 22(2):451-464. doi: 10.1016/j.intimp.2014.07.019
    [5]
    Mesiano G, Todorovic M, Gammaitoni L, et al. Cytokine-induced killer (CIK) cells as feasible and effective adoptive immunotherapy for the treatment of solid tumors[J]. Expert Opin Biol Ther, 2012, 12(6):673-684. doi: 10.1517/14712598.2012.675323
    [6]
    庞佳楠, 崔久嵬.细胞因子诱导的杀伤细胞治疗肿瘤的研究进展[J/CD].中华临床医师杂志:电子版, 2014, 8(15):2889-2993.

    Pang JN, Cui JW. Progress of cytokine-induced killer cells therapy in cancer[J/CD]. Chin J Clin:Electr Edit, 2014, 8(15):2889-2993.
    [7]
    Lee JH, Lee JH, Lim YS, et al. Adjuvant immunotherapy with autologous cytokine-induced killer cells for hepatocellular carcinoma[J]. Gastroenterology, 2015, 148(7):1383-1391. doi: 10.1053/j.gastro.2015.02.055
    [8]
    Pan K, Li YQ, Wang W, et al. The efficacy of cytokine-induced killer cell infusion as an adjuvant therapy for postoperative hepatocellular carcinoma patients[J]. Ann Surg Oncol, 2013, 20(13):4305-4311. doi: 10.1245/s10434-013-3144-x
    [9]
    杨旭, 许光, 雷振, 等. RECIST1. 1与WHO, RECIST1. 0标准评价周边型肺癌疗效比较[J].中国医学影像学杂志, 2012, 20(5):355-358. http://www.cnki.com.cn/Article/CJFDTOTAL-ZYYZ201205013.htm

    Yang X, Xu G, Lei Z, et al. Comparison of RECIST 1.1, RECIST 1.0 and WHO criteria for peripheral lung cancer response to treatment[J]. Chin J Med Imaging, 2012, 20(5):355-358. http://www.cnki.com.cn/Article/CJFDTOTAL-ZYYZ201205013.htm
    [10]
    Rosenberg SA, Restifo NP. Adoptive cell transfer as personalized immunotherapy for human cancer[J]. Science, 2015, 348(6230):62-68. doi: 10.1126/science.aaa4967
    [11]
    何志惠, 桑圣刚, 洪涛, 等. DC-CIK细胞治疗对晚期恶性肿瘤患者免疫功能及生活质量的影响[J].肿瘤预防与治疗, 2013, 26(4):213-215. http://www.cqvip.com/qk/97313b/201304/47110780.html

    He ZH, Sang SG, Hong T, et al. The effects of DC and CIK cell treatment on the quality of life and immune function in patients with advanced cancer[J]. J Cancer Contr Treat, 2013, 26(4):213-215. http://www.cqvip.com/qk/97313b/201304/47110780.html
    [12]
    Rosenberg SA, Restifo NP, Yang JC, et al. Adoptive cell transfer:a clinical path to effective cancer immunotherapy[J]. Nat Rev Cancer, 2008, 8(4):299-308. doi: 10.1038/nrc2355
    [13]
    Matsueda S, Graham DY. Immunotherapy in gastric cancer[J]. World J Gastroenterol, 2014, 20(7):1657-1666. doi: 10.3748/wjg.v20.i7.1657
    [14]
    Qian S, Shi P, Xie Y, et al. Clinical study of autologous cytokine-induced killer cells for the consolidation treatment of elderly patients with diffuse large B-cell lymphoma[J]. Blood, 2014, 124(21):4463-4463. http://cn.bing.com/academic/profile?id=2523141632&encoded=0&v=paper_preview&mkt=zh-cn
    [15]
    Rettinger E, Huenecke S, Pfirrmann V, et al. Repetitive infusions of cytokine-induced killer (CIK) cells for treatment of impending relapse in high-risk leukemia patients after allogeneic stem cell transplantation[J]. Blood, 2014, 124(21):2438-2438. http://cn.bing.com/academic/profile?id=2395952765&encoded=0&v=paper_preview&mkt=zh-cn
    [16]
    杨帆, 张琪, 陈规划.肝癌细胞免疫治疗进展[J].外科研究与新技术, 2013, 2(4):262-266. http://www.cnki.com.cn/Article/CJFDTOTAL-TJYE201304015.htm

    Yang F, Zhang Q, Chen GH. Cellular immunotherapy of hepatocellar carcinoma[J]. Surg Res New Tech, 2013, 2(4):262-266. http://www.cnki.com.cn/Article/CJFDTOTAL-TJYE201304015.htm
    [17]
    Schreiber RD, Old LJ, Smyth MJ. Cancer immunoediting:integrating immunity's roles in cancer suppression and promotion[J]. Science, 2011, 331(6024):1565-1570. doi: 10.1126/science.1203486
    [18]
    王士勇, 张晖, 杜微丽, 等.纤维连接蛋白诱导CIK细胞治疗晚期癌症患者的安全性及疗效评价[J].中国肿瘤临床, 2009, 36(20):1163-1166. http://www.cnki.com.cn/Article/CJFDTOTAL-ZGZL200920007.htm

    Wang SY, Zhang H, Du WL, et al. Therapeutic safety and effects of cytokine induced killer cells activated by retronectin for advanced cancer patients[J]. Chin J Clin Oncol, 2009, 36(20):1163-1166. http://www.cnki.com.cn/Article/CJFDTOTAL-ZGZL200920007.htm
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