Volume 6 Issue 6
Nov.  2015
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Article Navigation >  ORGAN TRANSPLANTATION  > 2015  >  6(6): 392-396, 414
Wei Xing, Cai Ming, Li Xiang, et al. Therapeutic effect and safety of acipimox combined with small-dose atorvastatin on combined hyperlipidemia after renal transplantation[J]. ORGAN TRANSPLANTATION, 2015, 6(6): 392-396, 414. doi: 10.3969/j.issn.1674-7445.2015.06.009
Citation: Wei Xing, Cai Ming, Li Xiang, et al. Therapeutic effect and safety of acipimox combined with small-dose atorvastatin on combined hyperlipidemia after renal transplantation[J]. ORGAN TRANSPLANTATION, 2015, 6(6): 392-396, 414. doi: 10.3969/j.issn.1674-7445.2015.06.009
shu

Therapeutic effect and safety of acipimox combined with small-dose atorvastatin on combined hyperlipidemia after renal transplantation

doi: 10.3969/j.issn.1674-7445.2015.06.009

  • The First Department of Urology, Organ Transplantation Research Institute of People's Liberation Army, the 309 Hospital of People's Liberation Army, Beijing 100091, China

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  • Corresponding author: Cai Ming, Email:caiming@medmail.com.cn
  • Received Date: 2015-07-12
    Available Online: 2021-01-19
  • Publish Date: 2015-11-15
    Abstract
  •   Objective  To assess the therapeutic effect and safety of acipimox combined with small-dose atorvastatin on combined hyperlipidemia after renal transplantation.  Methods  Fifty-six patients complicated with combined hyperlipidemia after renal transplantation were randomized into the combined small-dose group [n=28, acipimox (250 mg, twice a day)+atorvastatin (10 mg, once a day)] and normal dose group [n=28, atorvastatin (20-40 mg, once a day)]. Total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterin (HDL-C), low density lipoprotein cholesterin (LDL-C), aspartate aminotransaminase (AST), alanine aminotransferase (ALT), serum creatinine (Scr), blood urea nitrogen (BUN), uric acid (UA) and creatine kinase (CK) were observed before treatment and 1, 2 and 3 months after treatment. Adverse drug reaction was recorded.  Results  Compared with those before treatment, TC, TG and LDL-C of the normal dose group and the combined small-dose group decreased after treatment, but HDL-C increased, and the difference had statistical significance (all in P < 0.01). Compared with the normal dose group, TG and LDL-C of the combined small-dose group were lower and HDL-C was higher, and the difference had statistical significance (all in P < 0.01). At each time point before and after treatment, ALT, AST, Scr, BUN, UA and CK of the normal dose group and the combined small-dose group showed no statistically significant difference (all in P>0.05). There was significant difference in the incidence of adverse reactions in the digestive system, nervous system, musculoskeletal system and skin/vascular of the normal dose group and the combined small-dose group (all in P < 0.05).  Conclusions  Acipimox combined with small-dose atorvastatin can treat combined hyperlipidemia after renal transplantation safely and effectively.

     

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  • [1]
    He LP, Tang XY, Ling WH, et al. Early C-reactive protein in the prediction of long-term outcomes after acute coronary syndromes: a meta-analysis of longitudinal studies[J]. Heart, 2010, 96(5):339-346. doi: 10.1136/hrt.2009.174912
    [2]
    乙成成, 刘雯雯, 张颖秋, 等.低密度脂蛋白胆固醇与高密度脂蛋白胆固醇的比值与动脉粥样硬化的关系[J].第二军医大学学报, 2011, 32(2):224-226. http://www.cnki.com.cn/Article/CJFDTOTAL-DEJD201102026.htm

    Yi CC, Liu WW, Zhang YQ, et al. Relationship of low-and high-density lipoprotein cholesterol with atherosclerosis[J]. Acad J Sec Mil Med Univ, 2011, 32(2):224-226. http://www.cnki.com.cn/Article/CJFDTOTAL-DEJD201102026.htm
    [3]
    Emerging Risk Factors Collaboration, Erqou S, Kaptoge S, et al. Lipoprotein(a) concentration and the risk of coronary heart disease, stroke, and nonvascular mortality[J]. JAMA, 2009, 302(4):412-423. doi: 10.1001/jama.2009.1063
    [4]
    Riella LV, Gabardi S, Chandraker A. Dyslipidemia and its therapeutic challenges in renal transplantation[J]. Am J Transplant, 2012, 12(8):1975-1982. doi: 10.1111/j.1600-6143.2012.04084.x
    [5]
    Takagi H, Umemoto T. Low-density lipoprotein cholesterol-independent effects of statins on coronary artery disease[J]. Am J Cardiol, 2011, 107(2):336. http://cn.bing.com/academic/profile?id=2101184907&encoded=0&v=paper_preview&mkt=zh-cn
    [6]
    Huisa BN, Stemer AB, Zivin JA. Atorvastatin in stroke: a review of SPARCL and subgroup analysis[J]. Vasc Health Risk Manag, 2010, 6:229-236. http://cn.bing.com/academic/profile?id=2023123197&encoded=0&v=paper_preview&mkt=zh-cn
    [7]
    Chung YH, Lee YC, Chang CH, et al. Statins of high versus low cholesterol-lowering efficacy and the development of severe renal failure[J]. Pharmacoepidemiol Drug Saf, 2013, 22(6):583-592. doi: 10.1002/pds.v22.6
    [8]
    Graziano TS, Cuzzullin MC, Franco GC, et al. Statins and antimicrobial effects: simvastatin as a potential drug against staphylococcus aureus biofilm[J]. PLoS One, 2015, 10(5):e0128098. doi: 10.1371/journal.pone.0128098
    [9]
    刘凤阁, 陈静.降脂通脉胶囊联合阿托伐他汀钙治疗混合型高脂血症疗效观察[J].中国医药导报, 2011, 8(27):71-72. http://www.cnki.com.cn/Article/CJFDTOTAL-YYCY201127032.htm

    Liu FG, Chen J. Clinical observation of Jiangzhi Tongmai capsule combined with atorvastatin calcium tablets in treating combined hyperlipidemia[J]. Chin Med Her, 2011, 8(27):71-72. http://www.cnki.com.cn/Article/CJFDTOTAL-YYCY201127032.htm
    [10]
    Fruchart JC, Sacks FM, Hermans MP, et al. Implications of the ACCORD lipid study: perspective from the Residual Risk Reduction Initiative (R(3)i)[J]. Curr Med Res Opin, 2010, 26(8):1793-1797. doi: 10.1185/03007995.2010.489341
    [11]
    Choe EY, Wang HJ, Kwon O, et al. HMG CoA reductase inhibitor treatment induces dysglycemia in renal allograft recipients[J]. Transplantation, 2014, 97(4):419-425. doi: 10.1097/01.TP.0000437427.04733.ad
    [12]
    Ivandić E, Bašić-Jukić N. Liver damage caused by atorvastatin and cyclosporine in patients with renal transplant[J]. Acta Med Croatica, 2014, 68(2):175-178. http://cn.bing.com/academic/profile?id=399695850&encoded=0&v=paper_preview&mkt=zh-cn
    [13]
    Panza GA, Taylor BA, Dada MR, et al. Changes in muscle strength in individuals with statin-induced myopathy:a summary of 3 investigations[J]. J Clin Lipidol, 2015, 9(3):351-356. doi: 10.1016/j.jacl.2015.01.004
    [14]
    Tsartsalis AN, Dokos C, Kaiafa GD, et al. Statins, bone formation and osteoporosis:hope or hype?[J]. Hormones, 2012, 11(2):126-139. doi: 10.14310/horm.2002.1149
    [15]
    Hoeger S, Benck U, Petrov K, et al. Atorvastatin donor pre-treatment in a model of brain death and allogeneic kidney transplantation in rat[J]. Ann Transplant, 2012, 17(1):79-85. doi: 10.12659/AOT.882639
    [16]
    Garcia GG, Harden P, Chapman J, et al. The global role of kidney transplantation[J]. Nephrol Dial Transplant, 2013, 28(8):e1-e5. doi: 10.1093/ndt/gfs013
    [17]
    赵瑞虹, 宁均, 郭蔚莹, 等.烟酸与辛伐他汀联合治疗对动脉粥样硬化患者脂联素及高敏C反应蛋白的影响[J].中国老年学杂志, 2011, 31(4):576-578. http://www.cnki.com.cn/Article/CJFDTOTAL-ZLXZ201104010.htm

    Zhao RH, Ning J, Guo WY, et al. The influence of nicotinic acid and simvastatin combined treatment on adiponectin and high-sensitivity c-reactive protein in patients with atherosclerosis[J]. Chin J Gerontol, 2011, 31(4):576-578. http://www.cnki.com.cn/Article/CJFDTOTAL-ZLXZ201104010.htm
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