Pathological changes of renal grafts from elderly donor kidney in young recipients

Fang Jiali; Chen Zheng; Ma Junjie; Li Guanghui; Xu Lu; Zhang Lei; Guo Yuhe; Zhang Yirui; Pan Guanghui

doi:10.3969/j.issn.1674-7445.2015.05.012

Volume 6 Issue 5

Sep. 2015

Turn off MathJax

Article Contents

Article Navigation > ORGAN TRANSPLANTATION > 2015 > 6(5): 335-339

Fang Jiali, Chen Zheng, Ma Junjie, et al. Pathological changes of renal grafts from elderly donor kidney in young recipients[J]. ORGAN TRANSPLANTATION, 2015, 6(5): 335-339. doi: 10.3969/j.issn.1674-7445.2015.05.012

Citation:

PDF( 1339 KB)

Pathological changes of renal grafts from elderly donor kidney in young recipients

doi: 10.3969/j.issn.1674-7445.2015.05.012

Department of Transplantation, the Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510260 China

More Information

Corresponding author: Pan Guanghui, Email:panguanghui@126.com
Received Date: 2015-06-25
Available Online: 2021-04-29
Publish Date: 2015-09-01

Abstract

Abstract

Objective To study the pathological changes of renal grafts from elderly donor in young recipients and to investigate the safety of kidney transplantation from elderly donors. Methods Fourteen elderly kidney donors (with the age > 55 years old) and fourteen young recipients (with the age < 30 years old) underwent living related donor renal transplantation at the Department of Transplantation of the Second Affiliated Hospital of Guangzhou Medical University from January 2008 to December 2008 were enrolled as the object of study. Every elderly donor kidney was performed time-zero biopsy and every young recipient was performed routine renal graft biopsy 6 months after transplantation. The pathological and structural changes of kidney tissues after renal transplantation from elderly donors were observed. Results The histopathological changes occurred at 6 months after transplantation from elderly kidney donors to young recipients. Compared with those before transplantation, the severity of renal arteriolar lesion and the index of renal arteriolar sclerosis alleviated after transplantation(P < 0.05), and the ratio of glomerulosclerosis did not change after transplantation (P > 0.05). The expression of fibronectin (FN) decreased after transplantation, but the difference had no statistical significance (P > 0.05). The expression of laminin (LN) decreased after transplantation (P < 0.05). Conclusions The histopathological structure of renal graft from elderly donors in young recipients has improved.
- Living transplantation,
- Age,
- Donor,
- Glomerulosclerosis,
- Renal interstitial fibrosis,
- Extracellular matrix

FullText(HTML)

References(21)

References

[1]	Lionaki S, Kapsia H, Makropoulos I, et al. Kidney transplantation outcomes from expanded criteria donors, standard criteria donors or living donors older than 60 years[J]. Ren Fail, 2014, 36(4):526-533. doi: 10.3109/0886022X.2013.876348
[2]	Li Y, Li J, Fu Q, et al. Kidney transplantation from living related donors aged more than 60 years:a single center experience[J]. Ren Fail, 2013, 35(9):1251-1254. doi: 10.3109/0886022X.2013.823873
[3]	Ferrari P, Lim W, Dent H, et al. Effect of donor-recipient age difference on graft function and survival in live-donor kidney transplantation[J]. Nephrol Dial Transplant, 2011, 26(2):702-708. doi: 10.1093/ndt/gfq383
[4]	李明喜, Nicholls K.肾移植供者的肾小动脉病变和肾小球硬化[J].肾脏病与透析肾移植杂志, 2001, 10(3):228-232. http://www.cnki.com.cn/Article/CJFDTOTAL-SZBY200103005.htm Li MX, Nicholls K. Renal arteriole lesion and glomerulosclerosis in donor kidneys[J]. Chin J Nephrol Dial Transplant, 2001, 10(3):228-232. http://www.cnki.com.cn/Article/CJFDTOTAL-SZBY200103005.htm
[5]	Wanner N, Hartleben B, Herbach N, et al. Unraveling the role of podocyte turnover in glomerular aging and injury[J]. J Am Soc Nephrol, 2014, 25(4):707-716. doi: 10.1681/ASN.2013050452
[6]	Takeda T, Imada A, Horiuchi A, et al. Age-related changes in morphological studies in rat and human kidney[J]. Nippon Jinzo Gakkai Shi, 1996, 38(12):555-662. https://www.ncbi.nlm.nih.gov/pubmed/9014474
[7]	Ruiz-Torres MP, Bosch RJ, O'Valle F, et al. Age-related increase in expression of TGF-beta 1 in the rat kidney:relationship to morphologic changes[J]. J Am Soc Nephrol, 1998, 9(5):782-791. http://www.ncbi.nlm.nih.gov/pubmed/9596075
[8]	丰贵文, 李金锋, 王跃, 等.西罗莫司替换钙调磷酸酶抑制剂治疗老年亲属供肾移植受者移植肾功能减退的疗效[J].器官移植, 2011, 2(4):194-196. http://www.cnki.com.cn/Article/CJFDTOTAL-QGYZ201104006.htm Feng GW, Li JF, Wang Y, et al. Effect of conversion from calcineurin inhibitors to sirolimus for renal function deterioration in living-related renal transplantation from elderly donors[J]. Organ Transplant, 2011, 2(4):194-196. http://www.cnki.com.cn/Article/CJFDTOTAL-QGYZ201104006.htm
[9]	陈莉萍, 张晓琳, 钱叶勇, 等.老年肾移植受者的临床分析与管理[J].中华器官移植杂志, 2014, 35(2):82-85. http://d.wanfangdata.com.cn/Periodical/zhqgyz98201402005 Chen LP, Zhang XL, Qian YY, et al. Clinical analysis and management of kidney transplantation in the older adults:monocentric retrospective analysis[J]. Chin J Organ Transplant, 2014, 35(2):82-85. http://d.wanfangdata.com.cn/Periodical/zhqgyz98201402005
[10]	Faconti L, Bruno RM, Ghiadoni L, et al.Ventricular and vascular stiffening in aging and hypertension[J]. Curr Hypertens Rev, 2015, 107:139-146. http://www.ncbi.nlm.nih.gov/pubmed/26022209
[11]	李虹, 白小涓, 刘强, 等.血管紧张素Ⅱ和NADPH氧化酶与血管衰老的相关性研究[J].中国老年学杂志, 2006, 26(4):493-496. http://www.cnki.com.cn/Article/CJFDTOTAL-ZLXZ200604029.htm Li H, Bai XJ, Liu Q, et al. Study on the relationship between angiotensin Ⅱ and NADPH oxidase and vascular aging[J]. Chin J Gerontol, 2006, 26(4):493-496. http://www.cnki.com.cn/Article/CJFDTOTAL-ZLXZ200604029.htm
[12]	Varcoe RL, Teo AB, Pelletier MH, et al. A nitinol "U-Clip" versus sutured arteriovenous anastomosis:local tissue response and intimal hyperplasia development in a sheep model[J]. Eur J Vasc Endovasc Surg, 2015, 49(3):344-352. doi: 10.1016/j.ejvs.2014.12.025
[13]	刘强, 白小涓, 李虹, 等.衰老大鼠主动脉增龄性重塑及其规律分析[J].中国老年学杂志, 2007, 27(7):612-614. http://www.cnki.com.cn/Article/CJFDTOTAL-ZLXZ200707007.htm Liu Q, Bai XJ, Li H, et al. Aortic ageing-related remodeling and analysis on remodeling regularity in the aged rats[J].Chin J Gerontol, 2007, 27(7):612-614. http://www.cnki.com.cn/Article/CJFDTOTAL-ZLXZ200707007.htm
[14]	Islam SF, Hadiuzzaman KM, Islam MN, et al. Role of protocol biopsy in early graft dysfunction in renal transplant recipient[J]. Mymensingh Med J, 2014, 23(2):286-289. https://www.ncbi.nlm.nih.gov/pubmed/24858156
[15]	Verma SK, Molitoris BA.Renal endothelial injury and microvascular dysfunction in acute kidney injury[J]. Semin Nephrol, 2015, 35(1):96-107. doi: 10.1016/j.semnephrol.2015.01.010
[16]	Xu HL, Ou C, Rong L, et al. The potential signal pathway between PAX2 and CD2AP in the renal interstitial fibrosis disease[J]. J Recept Signal Transduct Res, 2014, 34(4):290-298. doi: 10.3109/10799893.2013.876045
[17]	Zhou TB, Qin YH, Lei FY, et al. Association of prohibitin-1 and 2 with oxidative stress in rats with renal interstitial fibrosis[J]. Mol Biol Rep, 2014, 41(5):3033-3043. doi: 10.1007/s11033-014-3162-1
[18]	Long YB, Qin YH, Zhou TB, et al. Association of retinoic acid receptors with extracellular matrix accumulation in rats with renal interstitial fibrosis disease[J]. Int J Mol Sci, 2012, 13(11):14073-14085. http://www.ncbi.nlm.nih.gov/pubmed/23203050
[19]	Yevdokimova NY. High glucose-induced alterations of extracellular matrix of human skin fibroblasts are not dependent on TSP-1-TGF beta1 pathway[J]. J Diabetes Complications, 2003, 17(6):355-364. doi: 10.1016/S1056-8727(02)00225-8
[20]	Floege J, Johnson RJ, Gordon K, et al. Increased synthesis of extra celluar matrix in mesangial prolifertive mephritis[J]. Kidney Int, 1991, 40(3):477-488. doi: 10.1038/ki.1991.235
[21]	Zhou X, Zhang J, Xu C, et al. Curcumin ameliorates renal fibrosis by inhibiting local fibroblast proliferation and extracellular matrix deposition[J]. J Pharmacol Sci, 2014, 126(4):344-350. doi: 10.1254/jphs.14173FP

Relative Articles

Supplements(0)

Cited By

Proportional views

Proportional views

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

Figures(1) / Tables(2)

Get Citation

PDF

XML

Article Metrics

Article views (107) PDF downloads(8)

Pathological changes of renal grafts from elderly donor kidney in young recipients

doi: 10.3969/j.issn.1674-7445.2015.05.012

Abstract

References

Proportional views

Catalog

通讯作者: 陈斌, bchen63@163.com

Article Metrics

Proportional views

Related

Pathological changes of renal grafts from elderly donor kidney in young recipients

doi: 10.3969/j.issn.1674-7445.2015.05.012

Abstract

References

Proportional views

Catalog

通讯作者: 陈斌, bchen63@163.com

Article Metrics

Proportional views

Related

Export File

Citation

Format

Content