Volume 6 Issue 5
Sep.  2015
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Article Navigation >  ORGAN TRANSPLANTATION  > 2015  >  6(5): 326-330
Luo Yongwen, Qian Yeyong, Fan Yu, et al. Observation of curative effect of benazepril on polycythemia after kidney transplantation[J]. ORGAN TRANSPLANTATION, 2015, 6(5): 326-330. doi: 10.3969/j.issn.1674-7445.2015.05.010
Citation: Luo Yongwen, Qian Yeyong, Fan Yu, et al. Observation of curative effect of benazepril on polycythemia after kidney transplantation[J]. ORGAN TRANSPLANTATION, 2015, 6(5): 326-330. doi: 10.3969/j.issn.1674-7445.2015.05.010
shu

Observation of curative effect of benazepril on polycythemia after kidney transplantation

doi: 10.3969/j.issn.1674-7445.2015.05.010

  • People's Liberation Army Medical School, Beijing 100853, China

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  • Corresponding author: Qian Yeyong,Email:qianyy@medmail.com.cn
  • Received Date: 2015-05-23
    Available Online: 2021-04-29
  • Publish Date: 2015-09-01
    Abstract
  •   Objective  To observe the curative effect and adverse reaction of benazepril on polycythemia (PTE) after renal transplantation.  Methods  Twenty-two patients undergoing kidney transplantation for the first time at the Department of Urinary Surgery of the 309th Hospital of People's Liberation Army and developed PTE after renal transplantation from June 2012 to June 2013 were enrolled as the object of study. The patients were divided into the hypertension group (n=14) and the normal blood pressure group (n=8) according to whether the patients were with hypertension or not. The hypertension group was given benazepril with an initial dose of 10 mg/d and increased to the maximum dose of 40 mg/d according to the changes of patients' conditions. The normal blood pressure group was given benazepril with an initial dose of 5 mg/d and with the maintenance dose of 2.5 mg/d after hemoglobin and hematokrit returning to normal. The patients in two groups were followed up for 6 months. The curative effect and adverse reactions during the follow-up were compared between the two groups.  Results  After 6 months of treatment, 12 patients had marked effect, 1 had effect and 1 was improved in the hypertension group. Six patients had marked effect, 1 had effect and 1 had no effect in the normal blood pressure group. The difference of efficacy had no statistical significance between the two groups (P > 0.05). During the treatment, the blood pressure of the hypertension group dropped significantly (P < 0.05), while that of the normal blood pressure group had no significant change. Red blood cells, neutrophils, platelets, serum creatinine, uric acid and estimated glomerular filtration rate of the two groups had no obvious abnormality before and after treatment. One patient in the hypertension group developed irritable cough during the treatment and recovered after withdrawal.  Conclusions  It is safe and effective to take benazepril for patients with PTE after renal transplantation. It is recommended to start with small dose and the dose shall be adjusted according to blood pressure. The blood pressure, blood routine and renal function shall be monitored during the treatment.

     

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