Volume 6 Issue 4
Jul.  2015
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Article Navigation >  ORGAN TRANSPLANTATION  > 2015  >  6(4): 249-253
Huang Senlin, Yu Lixin, Deng Wenfeng, et al. Pure red cell aplasia caused by human parvovirus B19 infection after renal transplantation: a report of 2 cases and literature review[J]. ORGAN TRANSPLANTATION, 2015, 6(4): 249-253. doi: 10.3969/j.issn.1674-7445.2015.04.009
Citation: Huang Senlin, Yu Lixin, Deng Wenfeng, et al. Pure red cell aplasia caused by human parvovirus B19 infection after renal transplantation: a report of 2 cases and literature review[J]. ORGAN TRANSPLANTATION, 2015, 6(4): 249-253. doi: 10.3969/j.issn.1674-7445.2015.04.009
shu

Pure red cell aplasia caused by human parvovirus B19 infection after renal transplantation: a report of 2 cases and literature review

doi: 10.3969/j.issn.1674-7445.2015.04.009

  • Nanfang Medical University, 510050 Guangzhou, China

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  • Corresponding author: Miao Yun, Email:miaoyunecho@126.com
  • Received Date: 2015-02-16
    Available Online: 2021-01-19
  • Publish Date: 2015-07-15
    Abstract
  •   Objective  To investigate the diagnosis and treatment characteristics of pure red cell aplasia (PRCA) caused by human parvovirus (HPV) B19 infection after renal transplantation.  Methods  Two cases with PRCA caused by HPV B19-induced after renal transplantation, who were treated in the Department of Organ Transplantation, Nanfang Hospital, Southern Medical University, were summarized. Combined with literature review, the clinical characteristics, diagnostic method, course of treatment and prognosis of such disease were investigated.  Results  Two renal transplant recipients developed severe anemia early after transplantation with progressive deterioration and failed transfusion therapy. Other causes of anemia were ruled out and two patients were diagnosed as PRCA caused by HPV B19 infection according to bone marrow aspiration and biopsy as well as HPV DNA detection by fluorescent polymerase chain reaction (PCR). The symptoms of anemia were improved significantly after adjustment of immunosuppressive treatment protocol and intravenous immunoglobulin (IVIG).  Conclusions  For patients with unexplained and progressed anemia early after renal transplantation, especially those complicated with reticulocyte deficiency, the possibility of PRCA caused by HPV B19 infection shall be considered. The results of bone marrow aspiration and fluorescent PCR are the main bases for diagnosing PRCA. Immunosuppressive agents reduction and application of IVIG are the major treatment measures. Most of patients have great prognosis after treatment, but this disease is likely to recur.

     

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  • [1]
    Macdougall IC, Casadevall N, Locatelli F, et al. Incidence of erythropoietin antibody-mediated pure red cell aplasia:the Prospective Immunogenicity Surveillance Registry (PRIMS)[J]. Nephrol Dial Transplant, 2015, 30(3):451-460. doi: 10.1093/ndt/gfu297
    [2]
    Xiao C, Wang CX, Liu LS, et al. Clinical investigation of human parvovirus B19 infection after renal transplantation in China[J]. Transplant Proc, 2013, 45(4):1593-1599. doi: 10.1016/j.transproceed.2013.02.040
    [3]
    Chang HJ, Sinn DH, Cho SG, et al. Pure red-cell aplasia and autoimmune hemolytic anemia in a patient with acute hepatitis A[J]. Clin Mol Hepatol, 2014, 20(2):204-207. doi: 10.3350/cmh.2014.20.2.204
    [4]
    Hirokawa M, Sawada K, Fujishima N, et al. Long-term outcome of patients with acquired chronic pure red cell aplasia (PRCA) following immunosuppressive therapy:a final report of the nationwide cohort study in 2004/2006 by the Japan PRCA collaborative study group[J]. Br J Haematol, 2015, DOI:10.1111/bjh.13376[Epub ahead of print].
    [5]
    Kelleher E, Mcmahon C, Mcmahon CJ. A case of parvovirus B19-induced pure red cell aplasia in a child following heart transplant[J]. Cardiol Young, 2015, 25(2):373-375. doi: 10.1017/S1047951114000225
    [6]
    Varshney P, Verma V, Verma N, et al. An unusual case of post-renal transplant anemia induced by parvovirus B19[J]. Indian J Transpl, 2014, 8(2):54-56. doi: 10.1016/j.ijt.2014.04.003
    [7]
    李栋林, 梁廷波.实体器官移植后纯红细胞再生障碍性贫血的病因与诊治[J].中华医学杂志, 2007, 86(42):3020-3022. http://www.cnki.com.cn/Article/CJFDTOTAL-ZHYX200642023.htm

    Li DL, Liang TB. Diagnosis and etiology treatment of pure red blood cell aplastic anemia after solid organ transplantation[J]. Natl Med J China, 2007, 86(42):3020-3022. http://www.cnki.com.cn/Article/CJFDTOTAL-ZHYX200642023.htm
    [8]
    李帅阳, 沈兵, 刘志宏, 等.肾移植术后人微小病毒B19感染导致纯红细胞增生障碍性贫血[J].现代生物医学进展, 2012, 12(14):2698-2702. http://www.cnki.com.cn/Article/CJFDTOTAL-SWCX201214025.htm

    Li SY, Shen B, Liu ZH, et al. Human parvovirus B 19-induced pure red cell aplasia in patients with allograft renal transplantation[J]. Prog Mod Biomed, 2012, 12(14):2698-2702. http://www.cnki.com.cn/Article/CJFDTOTAL-SWCX201214025.htm
    [9]
    Wong TY, Chan PK, Leung CB, et al. Parvovirus B19 infection causing red cell aplasia in renal transplantation on tacrolimus[J]. Am J Kidney Dis, 1999, 34(6):1132-1136. doi: 10.1016/S0272-6386(99)70021-1
    [10]
    Lui SL, Luk WK, Cheung CY, et al. Nosocomial outbreak of parvovirus B19 infection in a renal transplant unit[J]. Transplantation, 2001, 71(1):59-64. doi: 10.1097/00007890-200101150-00010
    [11]
    陈燕燕, 黄洪锋, 彭文翰, 等.肾移植后微小病毒B19感染导致纯红细胞再生障碍性贫血八例[J].中华器官移植杂志, 2013, 34(4):231-234. http://d.wanfangdata.com.cn/Periodical/zhqgyz98201304010

    Chen YY, Huang HF, Peng WH, et al. Pure red cell apalsia caused by infection of human parvovirus B19 post-renal transplantation:8 cases report and review[J]. Chin J Organ Transplant, 2013, 34(4):231-234. http://d.wanfangdata.com.cn/Periodical/zhqgyz98201304010
    [12]
    Kooistra K, Mesman HJ, de Waal M, et al. Epidemiology of high-level parvovirus B19 viraemia among Dutch blood donors, 2003-2009[J]. Vox Sang, 2011, 100(3):261-266. doi: 10.1111/vox.2011.100.issue-3
    [13]
    Eis-Hübinger AM, Oldenburg J, Brackmann HH, et al. The prevalence of antibody to parvovirus B19 in hemophiliacs and in the general population[J]. Zentralbl Bakteriol, 1996, 284(2/3):232-240. https://www.researchgate.net/publication/14368779_The_Prevalence_of_Antibody_to_Parvovirus_B19_in_Hemophiliacs_and_in_the_General_Population
    [14]
    Abdollahi A, Shoar S, Sheikhbahaei S, et al. Status of immunity against PVB19 in HIV-infected patients according to CD4(+) cell count, and antiretroviral therapy regimen groups[J]. Niger Med J, 2014, 55(1):20-23. doi: 10.4103/0300-1652.128153
    [15]
    Niccoli G, Severino A, Pieroni M, et al. Parvovirus B19 at the culprit coronary stenosis predicts outcome after stenting[J]. Eur J Clin Invest, 2014, 44(2):209-218. doi: 10.1111/eci.2014.44.issue-2
    [16]
    井丽萍, 邵宗鸿.获得性纯红细胞再生障碍发病机制及治疗[J].中华血液学杂志, 2004, 25(8):510-512. http://www.cnki.com.cn/Article/CJFDTOTAL-ZHXY200408023.htm

    Jing LP, Shao ZH. Pathogenesis and treatment of acquired pure red blood cell regeneration barrier[J]. Chin J Hematol, 2004, 25(8):510-512. http://www.cnki.com.cn/Article/CJFDTOTAL-ZHXY200408023.htm
    [17]
    Reindl-Schwaighofer R, Oberbauer R. Blood disorders after kidney transplantation[J]. Transplant Rev, 2014, 28(2):63-75. doi: 10.1016/j.trre.2013.10.001
    [18]
    Atalay A, Gökahmetoğ lu S, Durmaz S, et al. Investigation of Epstein-Barr virus and parvovirus b19 DNA in allogeneic stem cell transplant patients[J]. Turk J Haematol, 2014, 31(2):155. doi: 10.4274/tjh
    [19]
    Green LK, Fraire AE. Parvovirus[M]. Berlin:Springer, 2014:133-140.
    [20]
    Eid AJ, Chen SF, AST Infectious Diseases Community of Practice. Human parvovirus B19 in solid organ transplantation[J]. Am J Transplant, 2013, 13(s4):201-205. doi: 10.1111/ajt.2013.13.issue-s4
    [21]
    Choi SH, Chang SP, Won JC, et al. A case of persistent anemia in a renal transplant recipient:association with parvovirus B19 infection[J]. Scand J Infect Dis, 2002, 34(1):71-75. doi: 10.1080/003655402753395247
    [22]
    Crabol Y, Terrier B, Rozenberg F, et al. Intravenous immunoglobulin therapy for pure red cell aplasia related to human parvovirus B19 infection:a retrospective study of 10 patients and review of the literature[J]. Clin Infect Dis, 2013, 56(7):968-977. doi: 10.1093/cid/cis1046
    [23]
    Pascual J, Jiménez C, Franco A, et al. Early-onset anemia after kidney transplantation is an independent factor for graft loss:a multicenter, observational cohort study[J]. Transplantation, 2013, 96(8):717-725. doi: 10.1097/TP.0b013e31829f162e
    [25]
    王丹妹.人类微小病毒B19感染与乙型肝炎的关系[J].实用预防医学, 2006, 13(5):1334-1335. http://www.cnki.com.cn/Article/CJFDTOTAL-SYYY200605113.htm

    Wang DM. Hepatitis B and human parvovirus B19 infection[J]. Pract Prev Med, 2006, 13(5):1334-1335. http://www.cnki.com.cn/Article/CJFDTOTAL-SYYY200605113.htm
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