Clinical analysis of 47 cases with mid-and long-term biliary complications after liver transplantation

Jiang Weiwei; Li Jun; Chen Hong; Shen Zhongyang; Cheng Mingliang; Fan Tieyan; Wang Xu; Zhang Qing; Chen Xinguo; Xu Guangxun

doi:10.3969/j.issn.1674-7445.2015.02.005

Volume 6 Issue 2

Mar. 2015

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Jiang Weiwei, Li Jun, Chen Hong, et al. Clinical analysis of 47 cases with mid-and long-term biliary complications after liver transplantation[J]. ORGAN TRANSPLANTATION, 2015, 6(2): 93-97. doi: 10.3969/j.issn.1674-7445.2015.02.005

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Clinical analysis of 47 cases with mid-and long-term biliary complications after liver transplantation

doi: 10.3969/j.issn.1674-7445.2015.02.005

Guiyang Medical College, Guiyang 550004, China

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Corresponding author: Chen Hong, E-mail:ch61520@163.com; Shen Zhongyang, E-mail:zhongyangshen@gmail.com
Received Date: 2014-11-12
Publish Date: 2015-03-01

Abstract

Abstract

Objective To investigate the incidence, treatment and outcome of mid-and long-term biliary complications after liver transplantation. Methods Clinical data of 651 patients who underwent liver transplantation at General Hospital of Armed Police Forces from April 2002 to February 2012 were retrospectively studied to analyze the incidence, treatment and outcome of mid-and long-term biliary complications after liver transplantation. Results Among 651 liver transplant cases, 47 patients (7.2%) developed mid-and long-term biliary complications. The mean time of onset was 21 months. Forty seven patients underwent 48 cases of treatment in total. Nine cases received anti-inflammatory therapy alone. Fourteen cases were treated with choledochoscope lithotomy, choledochoscope biliary cast or placing the biliary support tube. And 13 cases underwent endoscopic retrograde cholangiopancreatography(ERCP) nephrolithotomy, expanding the bile duct or placing the biliary support tube, including 1 patient was switched to percutaneous transhepatic cholangial drainage(PTCD) due to ERCP failure. Seven cases received drainage by PTCD and 5 cases were treated with anti-inflammatory therapy combined with choledochoscope or PTCD. The total efficacious rate was 92%. Among 3 invalid patients, two patients were treated with secondary liver transplantation and one died. Conclusions The mid-and long-term biliary complications probably occur after liver transplantation. Individualized therapies should be chosen based upon the types and severity of biliary complications, which yields relatively high efficacious rate. Secondary liver transplantation should be performed as necessary.
- Liver transplantation,
- Biliary complications,
- Interventional management

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References

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Clinical analysis of 47 cases with mid-and long-term biliary complications after liver transplantation

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Clinical analysis of 47 cases with mid-and long-term biliary complications after liver transplantation

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