Study on the relationship between panel reactive antibody and long-term prognosis of transplant renal function

  Objective   To study the impact of panel reactive antibody (PRA) on the long-term prognosis of transplant renal function after renal transplantation.

  Methods   The objects of this study were 224 patients, who underwent renal transplantation, received PRA test about 2 weeks after operation and followed up in Affiliated Beijing Friendship Hospital of Capital Medical University from January 1994 to December 2004. According to the PRA test results, the patients were divided into two groups: negative group (n=195) and positive group(n=29). PRA of patients in negative group were tested again in 2007. Serum creatinine (Scr) of patients in both groups were tested recently (from October 2013 to April 2014) to know about the renal function. The rates of long-term normal transplant renal function between PRA positive patients (including PRA re-test positive patients) and PRA negative patients were compared.

  Results   In 29 cases of positive group, the re-test result in April 2014 showed that 18 cases were observed with loss(n=17) or decline(n=1) of renal function, and 11 cases were observed with normal renal function. In 195 cases of negative group, a total of 153 cases were re-tested with PRA negative in 2007, 148 cases were re-tested with normal renal function in April 2014, and 5 cases were observed with decline or loss of renal function. A total of 42 cases were re-tested with PRA positive in 2007 and the transplant renal function was observed decline or loss by varying degrees. There were a total of 71 cases with PRA positive before 2004 and when re-tested in 2007, and 11 cases were re-tested with normal renal function in April 2014. The rate of long-term normal transplant renal function was 15.5%. There were 153 cases with PRA negative and 148 cases were re-tested with normal renal function in April 2014. The rate of long-term normal transplant renal function was 96.7%. Significant difference was observed in the rates of long-term normal transplant renal function between PRA positive patients and PRA negative patients (P<0.005).

  Conclusions   PRA after renal transplantation has obvious impacts on the long-term prognosis of transplant renal function.