Volume 5 Issue 5
Sep.  2014
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Li Jian, Xu Yahong, Guo Yu, et al. Effect of two biological immunologic induction therapies on renal transplant recipients[J]. ORGAN TRANSPLANTATION, 2014, 5(5): 299-303. doi: 10.3969/j.issn.1674-7445.2014.05.008
Citation: Li Jian, Xu Yahong, Guo Yu, et al. Effect of two biological immunologic induction therapies on renal transplant recipients[J]. ORGAN TRANSPLANTATION, 2014, 5(5): 299-303. doi: 10.3969/j.issn.1674-7445.2014.05.008
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Effect of two biological immunologic induction therapies on renal transplant recipients

doi: 10.3969/j.issn.1674-7445.2014.05.008

  • Department of Urology, Urology Center of Chengdu Military Command, the 452nd Hospital of Chinese People's Liberation Army, Chengdu 610021, China

  • Received Date: 2014-05-08
  • Publish Date: 2014-09-15
    Abstract
  •   Objective   To evaluate efficacy and safety of two different biologicals in immunologic induction therapy on renal transplant recipients.   Methods   Clinical data of 78 renal transplant recipients who received biological immunologic induction therapy in Department of Urology of the 452nd Hospital of Chinese People's Liberation Army from June 2008 to April 2013,were retrospectively analyzed. According to different biological immunologic induction therapy, the recipients were divided into two groups, monoclonal antibody group(group A, n=35, received treatment of basiliximab) and polyclonal antibody group [group B, n=43, received treatment of antithymocyte globulin(ATG)]. And the other recipients who didn't receive immunologic induction therapy in the hospital during the corresponding period were chosen as control group(group C, n=32). The survival rates of recipient and kidney in 3 groups at 12th weeks after transplantation were analyzed. The levels of serum creatinine(Scr) of recipients in 3 groups were monitored at 7, 14, 30, 60 d after transplantation. The occurrence rates of complications including acute rejection, delayed graft function and infection were compared among 3 groups.   Results   At 12th weeks after transplantation, the survival rates of recipient and kidney in 3 groups were 100% and 100% in group A, 97.7% and 97.7% in group B, 100% and 96.9% in group C. There was no significant difference among 3 groups(all in P>0.05). Compared with group C, the Scr levels in group A and B decreased significantly at 7, 14 d after transplantation(all in P<0.05). Compared with group C, the incidence rates of acute rejection decreased in group A and B(all in P<0.05). There was no significant difference in the incidence rates of delayed graft function among 3 groups(all in P>0.05). The incidence rate of infection in group B was significantly higher than those in group A and C(all in P<0.05).   Conclusion   Immunologic induction therapy is safe and effective in the application on renal transplant recipients.

     

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